Results 51 to 60 of about 30,638 (285)

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

Endogenous opioids in wound-site neutrophils of sternotomy patients. [PDF]

PLoS ONE, 2012
Postoperative pain management is a critical aspect of patient care. The inflammatory state of the post-sternotomy surgical wound sensitizes nerve endings, causing pain. Unrelieved or improperly managed pain compromises wound healing.
Hamdy Awad, Motaz Abas, Haytham Elgharably, Ravi Tripathi, Tykie Theofilos, Sujatha Bhandary, Chittoor Sai-Sudhakar, Chandan K Sen, Sashwati Roy   +8 more
doaj   +1 more source

Clinical and echocardiographic phenotype of cardiac wasting in patients with advanced cancer

European Journal of Heart Failure, EarlyView.
Cardiac wasting‐associated cardiomyopathy in cancer patients. E/e', early diastolic filling velocity (E) over mitral annulus early diastolic tissue velocity (e'); GLS, global longitudinal strain; LV, left ventricular; LVEF, left ventricular ejection fraction; TAPSE, tricuspid annular plane systolic excursion.
Markus S. Anker, Muhammad Shahzeb Khan, Anja Nikolski, Jan Porthun, Muhammad Sameer Arshad, Sara Hadzibegovic, Alessia Lena, Lucie Kretzler, Jonathan L. Hella, Marco Witkowski, Kathrin Rieger, Johann Ahn, Dominik P. Modest, Ulrich Keller, Lars Bullinger, Matthias Totzeck, Amir A. Mahabadi, Tienush Rassaf, Nikolaus Buchmann, Philipp Attanasio, Tanja Zeller, Mahir Karakas, Carlo G. Tocchetti, Ursula Wilkenshoff, John G. F. Cleland, Stephan von Haehling, Javed Butler, Ulf Landmesser   +27 more
wiley   +1 more source

BCM-7: Opioid-like Peptide with Potential Role in Disease Mechanisms

Molecules
Bovine milk is an essential supplement due to its rich energy- and nutrient-rich qualities. Caseins constitute the vast majority of the proteins in milk.
Ecem Bolat, Furkan Eker, Selin Yılmaz, Sercan Karav, Emel Oz, Charles Brennan, Charalampos Proestos, Maomao Zeng, Fatih Oz   +8 more
doaj   +1 more source

BmK-YA, an enkephalin-like peptide in scorpion venom. [PDF]

PLoS ONE, 2012
By screening extracts of venom from the Asian scorpion Buthus martensii Karsch (BmK) for their abilities to activate opioid receptors, we have identified BmK-YA, an amidated peptide containing an enkephalin-like sequence. BmK-YA is encoded by a precursor
Yan Zhang, Junyan Xu, Zhiwei Wang, Xiuli Zhang, Xinmiao Liang, Olivier Civelli   +5 more
doaj   +1 more source

Sojae Semen Praeparatum Fermented by Rhizopus chinensis and Bacillus sp. DU‐106 Alleviates Loperamide‐Induced Constipation in Rats via Regulating Calcium Signaling Pathways and the Gut Microbiota

Food Frontiers, EarlyView.
To investigate the effects of different processing methods of Sojae Semen Praeparartum (SSP) on constipation, we prepared SSP through fermentation using Rhizopus chinensis and Bacillus sp. DU‐106 as starter cultures, and examined its laxative effects and mechanisms in loperamide‐induced constipated Sprague‐Dawley (SD) rats.
Rong xiang Guo, Chao fan Zhao, Yan li Li, Yun xi Zhang, Fu Yao Luo, Yi hang Sun, Ya fei Wang, Jun Yuan Huang, Bing Du, Pan Li   +9 more
wiley   +1 more source

Lipid- and sugar-modified endomorphins: Novel targets for the treatment of neuropathic pain

Frontiers in Pharmacology, 2013
Endomorphins are endogenous opioid peptides that cause potent antinociception in rodent models of acute and neuropathic pain with less undesirable side effects than opioid alkaloids.
Pegah eVaramini, Istvan eToth, Istvan eToth   +2 more
doaj   +1 more source

Exploring the roles and impacts of pharmacists embedded in general practice: a scoping review

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background The role of the general practice pharmacist (GPP) in Australia is not yet clearly defined, and their clinical expertise remains underutilised in general practice settings. This may be attributed to a limited understanding of pharmacists' capabilities, which can hinder optimal GPP utilisation.
Christel Chandra, Brooke Bevis, Nazanin Falconer, Holly Foot   +3 more
wiley   +1 more source

Neuroendocrinology meets addiction: Emerging pharmacotherapies on the horizon. [PDF]

J Intern Med
Abstract Alcohol and other substance use disorders (ASUDs) are prevalent and major contributors to global morbidity and mortality. Their impact extends beyond the individual, imposing significant burdens on families, communities, healthcare systems, and society at large.
Loften A, Farokhnia M, Vendruscolo LF, Leggio L.   +3 more
europepmc   +2 more sources

Antihyperalgesic Effect of Buprenorphine Involves Nociceptin/Orphanin FQ Peptide–Receptor Activation in Rats With Spinal Nerve Injury–Induced Neuropathy

Journal of Pharmacological Sciences, 2013
.: We evaluated the effect of buprenorphine, a mixed agonist for μ-opioid receptors and nociceptin/orphanin FQ peptide (NOP) receptors, in neuropathic rats, using the paw pressure test. Buprenorphine, administered i.p. at 50, but not 20, μg/kg, exhibited
Tomoko Takahashi, Kazumasa Okubo, Shota Kojima, Hiroyuki Nishikawa, Motohide Takemura, Maho Tsubota-Matsunami, Fumiko Sekiguchi, Atsufumi Kawabata   +7 more
doaj   +1 more source