Results 61 to 70 of about 30,638 (285)

Associations Between Fatty Acid Levels in Human Blood and Trigeminovascular Tissues

Lipids, EarlyView.
ABSTRACT Omega‐3 and omega‐6 polyunsaturated fatty acids (PUFAs) are precursors to oxylipins that modulate pain and inflammation. We previously demonstrated that (1) a dietary intervention increasing omega‐3 and reducing omega‐6 PUFAs alters the concentration of these oxylipin precursors in blood, and (2) these changes are associated with reduced ...
Daisy Zamora, Mark S. Horowitz, Sharon F. Majchrzak‐Hong, Katherine Ness Shipley, Nicholas M. Salem, Ann I. Scher, Matthew R. Sapio, Michael J. Iadarola, Christopher E. Ramsden   +8 more
wiley   +1 more source

Opioid peptides and the heart [PDF]

Cardiovascular Research, 1999
See article by Millington et al. ([1], pages 107–116) in this issue. In this issue Millington et al. [1] describe the localization of pro-opiomelanocortin (POMC) message and peptide products in adult and neonatal rat heart. These authors are to be commended for delving into the esoteric area of cardiac endocrine function and opioid peptides.
openaire   +2 more sources

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Genetically Engineered Human Mesenchymal Stem Cells Produce Met-Enkephalin at Augmented Higher Levels in Vitro

Cell Transplantation, 2006
We have reported that transplantation of adrenal medullary chromaffin cells that release endogenous opioid peptides into pain modulatory regions in the CNS produce significant antinociceptive effects in patients with terminal cancer pain.
Ikuko Sugaya, Tingyu Qu, Kiminobu Sugaya, George D. Pappas   +3 more
doaj   +1 more source

Intratumoral Nerve Phased Development: A Promising Therapeutic Target

Medicine Bulletin, EarlyView.
ABSTRACT The nervous system has emerged as a critical regulator of tumor biology, engaging in dynamic crosstalk with cancer cells. Although the protumorigenic role of innervation is well established, increasing attention is now directed toward reciprocal influences—how tumors actively shape and remodel local nerve networks within the tumor ...
Xiangxian Che, Hang Wang, Han Wang, Yi‐Zhou Jiang   +3 more
wiley   +1 more source

A spider derived peptide, PnPP-19, induces central antinociception mediated by opioid and cannabinoid systems

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
Background Some peptides purified from the venom of the spider Phoneutria nigriventer have been identified as potential sources of drugs for pain treatment. In this study, we characterized the antinociceptive effect of the peptide PnPP-19 on the central
Daniela da Fonseca Pacheco, Ana Cristina Nogueira Freitas, Adriano Monteiro C. Pimenta, Igor Dimitri Gama Duarte, Maria Elena de Lima   +4 more
doaj   +1 more source

Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides abundantly expressed in MSNs, is a promising biomarker of striatal integrity, but region‐specific associations and its potential for early‐stage ...
Mena Farag, Michael J. Murphy, Nicola Z. Hobbs, Michela Leocadi, Kate Fayer, Olivia Thackeray, Johan Gobom, Marc Ciosi, Amanda Heslegrave, Henrik Zetterberg, Douglas R. Langbehn, Darren G. Monckton, Edward J. Wild, Sarah J. Tabrizi, Rachael I. Scahill   +14 more
wiley   +1 more source

The choroid plexus water density

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose To quantify normative ranges and circadian variability of the choroid plexus (ChP) water density in healthy adults. Methods Actigraphy assessments of circadian activity were performed for 5 days in healthy participants (n = 15; age = 28.5 ± 6.5 years) and subsequently participants underwent repeated, high spatial resolution proton ...
Abigail R. Dubois, Maeve Curtin, Kilian Hett, Melanie Leguizamon, Alexander K. Song, Maria Garza, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue   +8 more
wiley   +1 more source

Association of Glucagon‐Like Peptide‐1 Receptor Agonists With Cancer Risk in Older Adults With Type 2 Diabetes

Obesity, EarlyView.
ABSTRACT Objective The real‐world evidence on the association between glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) and cancer risk remains limited and mixed. Methods In 2013–2020 national Medicare claims data, we included cancer‐naïve patients with type 2 diabetes (T2D). We identified those who initiated GLP‐1 RA, sodium‐glucose cotransporter 2
Ying Lu, Hao Dai, Huilin Tang, William T. Donahoo, Thomas J. George, Ramon C. Sun, Sizun Jiang, Aik Choon Tan, Yi Guo, Jonathan D. Licht, John M. Allen, Kelvin P. Lee, Jingchuan Guo, Jiang Bian   +13 more
wiley   +1 more source

Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord

Nature Communications
Itch is a common side effect of opioid analgesics. The specific neurons mediating opioid-induced itch are still debated, and the mechanistic neuronal circuits remain elusive.
Qian Zeng, Yitong Li, Yifei Wu, Jiawei Wu, Kangtai Xu, Yiming Chen, Yunfei Rao, Nan Li, Yuhui Luo, Changyu Jiang, Chaoran Wu, Zilong Wang   +11 more
doaj   +1 more source