BmK-YA, an enkephalin-like peptide in scorpion venom. [PDF]
PLoS ONE, 2012 By screening extracts of venom from the Asian scorpion Buthus martensii Karsch (BmK) for their abilities to activate opioid receptors, we have identified BmK-YA, an amidated peptide containing an enkephalin-like sequence. BmK-YA is encoded by a precursor
Yan Zhang +5 more
doaj +1 more source
Identifying Risk of Opioid Use Disorder for Patients Taking Opioid Medications with Deep Learning [PDF]
arXiv, 2020 The United States is experiencing an opioid epidemic, and there were more than 10 million opioid misusers aged 12 or older each year. Identifying patients at high risk of Opioid Use Disorder (OUD) can help to make early clinical interventions to reduce the risk of OUD.
arxiv
Machine-learning Analysis of Opioid Use Disorder Informed by MOR, DOR, KOR, NOR and ZOR-Based Interactome Networks [PDF]
arXiv, 2023 Opioid use disorder (OUD) continuously poses major public health challenges and social implications worldwide with dramatic rise of opioid dependence leading to potential abuse. Despite that a few pharmacological agents have been approved for OUD treatment, the efficacy of said agents for OUD requires further improvement in order to provide safer and ...
arxiv
Journal of Neuroscience, 1984 Pharmacological and biochemical evidence has implied that a widespread opioid peptide system exists within the cerebral cortex to mediate a variety of opiate effects. However, immunocytochemical detection of opioid peptides in the cortex has been limited.
J. McGinty, D. van der Kooy, F. Bloom
semanticscholar +1 more source
Structure and dynamics of dynorphin peptide and its receptor [PDF]
arXiv, 2019 Dynorphin is a neuropeptide involved in pain, addiction and mood regulation. It exerts its activity by binding to the kappa opioid receptor (KOP) which belongs to the large family of G-protein coupled receptors. The dynorphin peptide was discovered in 1975, while its receptor was cloned in 1993.
arxiv
Specific receptor for the opioid peptide dynorphin: structure--activity relationships.
Proceedings of the National Academy of Sciences of the United States of America, 1981 The structural features responsible for the high potency and opiate receptor specificity of the opioid peptide dynorphin in the guinea pig ileum myenteric plexus were examined.
C. Chavkin, A. Goldstein
semanticscholar +1 more source
Lipid- and sugar-modified endomorphins: Novel targets for the treatment of neuropathic pain
Frontiers in Pharmacology, 2013 Endomorphins are endogenous opioid peptides that cause potent antinociception in rodent models of acute and neuropathic pain with less undesirable side effects than opioid alkaloids.
Pegah eVaramini +2 more
doaj +1 more source
Discovering heterogeneous subpopulations for fine-grained analysis of opioid use and opioid use disorders [PDF]
arXiv, 2018 The opioid epidemic in the United States claims over 40,000 lives per year, and it is estimated that well over two million Americans have an opioid use disorder. Over-prescription and misuse of prescription opioids play an important role in the epidemic.
arxiv
BCM-7: Opioid-like Peptide with Potential Role in Disease Mechanisms
MoleculesBovine milk is an essential supplement due to its rich energy- and nutrient-rich qualities. Caseins constitute the vast majority of the proteins in milk.
Ecem Bolat +8 more
doaj +1 more source
Learning Protein Dynamics with Metastable Switching Systems [PDF]
arXiv, 2016 We introduce a machine learning approach for extracting fine-grained representations of protein evolution from molecular dynamics datasets. Metastable switching linear dynamical systems extend standard switching models with a physically-inspired stability constraint.
arxiv