Folia Histochemica et Cytobiologica, 2010 In Mammals, opioid peptides are involved in various physiological processes including the reproductive function. The knowledge of the distribution of beta-endorphin, one of opioid peptides in Reptiles ovaries is very limited. Therefore, the present study
Jean Marie Exbrayat +2 more
doaj +1 more source
A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new $β$-arrestin inhibitor [PDF]
Pharmacological Research, 2025, 107597$\beta$-arrestins play pivotal roles in seven transmembrane receptor (7TMR) signalling and trafficking. To study their functional role in the regulation of specific receptor systems, current research relies mainly on genetic tools, as few pharmacological options are available.
arxiv +1 more source
Optimizing Return and Secure Disposal of Prescription Opioids to Reduce the Diversion to Secondary Users and Black Market [PDF]
arXiv, 2022 Opioid Use Disorder (OUD) has reached an epidemic level in the US. Diversion of unused prescription opioids to secondary users and black market significantly contributes to the abuse and misuse of these highly addictive drugs, leading to the increased risk of OUD and accidental opioid overdose within communities.
arxiv
Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. [PDF]
, 2020 Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the ...
Carrette, Lieselot LG +7 more
core
Hibernation-like state induced by an opioid peptide protects against experimental stroke
BMC Biology, 2009 BackgroundDelta opioid peptide [D-ala2,D-leU5]enkephalin (DADLE) induces hibernation in summer ground squirrels, and enhances preservation and survival of isolated or transplanted lungs and hearts.
C. Borlongan +4 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2021 Neuropathic pain is one of the most disabling forms of chronic pain and it is characterized by hyperalgesia and allodynia linked to an aberrant processing of pain transmission and to neuroinflammation.
Annamaria Fidilio +17 more
doaj +1 more source
Binding mode analyses of NAP derivatives as mu opioid receptor selective ligands through docking studies and molecular dynamics simulation [PDF]
, 2017 Mu opioid receptor selective antagonists are highly desirable because of their utility as pharmacological probes for receptor characterization and functional studies.
Wang, Huiqun +2 more
core +2 more sources
Challenges and new opportunities for detecting endogenous opioid peptides in reward
Addiction Neuroscience, 2022 The endogenous opioid peptide system, comprised of enkephalins, endorphins, dynorphins, and nociceptin, is a highly complex neurobiological system. Opioid peptides are derived from four precursor molecules and undergo several processing events yielding ...
Sineadh M. Conway +2 more
doaj
Endogenous opioids in wound-site neutrophils of sternotomy patients. [PDF]
PLoS ONE, 2012 Postoperative pain management is a critical aspect of patient care. The inflammatory state of the post-sternotomy surgical wound sensitizes nerve endings, causing pain. Unrelieved or improperly managed pain compromises wound healing.
Hamdy Awad +8 more
doaj +1 more source
Towards Better Opioid Antagonists Using Deep Reinforcement Learning [PDF]
arXiv, 2020 Naloxone, an opioid antagonist, has been widely used to save lives from opioid overdose, a leading cause for death in the opioid epidemic. However, naloxone has short brain retention ability, which limits its therapeutic efficacy. Developing better opioid antagonists is critical in combating the opioid epidemic.Instead of exhaustively searching in a ...
arxiv