Results 71 to 80 of about 30,638 (285)
Antiobesity Medications for Older Adults—the New, the Good, the Bad, and the Unknown
Obesity, EarlyView.ABSTRACT Objective Obesity affects 42% of older adults, with rates continuing to rise. This a complex condition influenced by non‐modifiable as well as modifiable risk factors. The disease can be treated through modifications to diet, physical activity, and behavior and more recently through antiobesity medications (AOMs) and surgery. Treatment must be
Anna Pendrey, Javier Sevilla‐Martir
wiley +1 more source
ChemistryOpen, EarlyView.A new series of β‐carboline‐{α‐acylaminoamide}‐bisindole hybrids (12a–l) employing an atom‐economical one‐pot Ugi four‐component reaction and their antibacterial testing alongside docking studies, is reported. A new series of β‐carboline‐{α‐acylaminoamide}‐bisindole hybrids (12a–l) is designed and synthesized employing an atom‐economical one‐pot Ugi ...
Ankit Kumar Atri +8 more
wiley +1 more source
Small, EarlyView.This review summarizes biomimetic design strategies for carbon‐based nanomaterials, including graphene oxide, carbon dots, and nanotubes, highlighting their tunable physicochemical properties for advanced biosensing and theranostic systems. Defined approaches such as DNA templating, peptide‐assisted assembly, and fluorescence switching are discussed ...
Marzieh Ramezani Farani +10 more
wiley +1 more source
Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience
Neural Plasticity, 2017 Psychological stress is a state of mental or emotional strain or tension that results from adverse or demanding circumstances. Chronic stress is well known to induce anxiety disorders and major depression; it is also considered a risk factor for ...
Mathilde S. Henry +3 more
doaj +1 more source
An opioid-like system regulating feeding behavior in C. elegans
eLife, 2015 Neuropeptides are essential for the regulation of appetite. Here we show that neuropeptides could regulate feeding in mutants that lack neurotransmission from the motor neurons that stimulate feeding muscles. We identified nlp-24 by an RNAi screen of 115
Mi Cheong Cheong +3 more
doaj +1 more source
Veterinary Record Case Reports, EarlyView.Abstract Osteoblastic metastases occur secondary to malignant epithelial tumours, and lead to marked periosteal hyperostosis and medullary sclerosis. These are rarely reported in dogs. A 7‐year‐old, neutered, female labrador retriever × standard poodle presented with a 4‐week history of progressive right hindlimb lameness, pyrexia and thoracolumbar ...
David Sheehan +5 more
wiley +1 more source
The Long Arc of Substance Use Policy Innovation in Medicaid: Looking Back, Looking Forward
The Milbank Quarterly, EarlyView.Policy Points The role of Medicaid in financing, organizing, and delivering substance use disorder (SUD) treatment has grown tremendously over time owing to expansions of eligibility and a push toward more uniformity in benefits. Current innovations in SUD treatment focus on expanding the delivery system to create a comprehensive continuum of care ...
BRENDAN SALONER
wiley +1 more source
Neuroimmune Interaction in the Regulation of Peripheral Opioid-mediated Analgesia in Inflammation
Frontiers in Immunology, 2016 Peripheral immune-cell-mediated analgesia in inflammation is an important endogenous mechanism of pain control. Opioid receptors localized on peripheral sensory nerve terminals are activated by endogenous opioid peptides released from immune cells to ...
Susan Hua
doaj +1 more source
Liver molecular networks associated with drinking behavior in nonhuman primates
Alcohol, Clinical and Experimental Research, EarlyView.We identified hepatic molecular networks that differed between light drinkers (LD) and very heavy drinkers (VHD) before they were exposed to alcohol, as well as epigenetic differences between LD and VHD in response to the same amount of alcohol.
Laura A. Cox +11 more
wiley +1 more source
Isolation and characterization of the opioid peptides from rat pituitary: beta-endorphin. [PDF]
, 1977 Menachem Rubinstein +2 more
openalex +1 more source