Results 81 to 90 of about 4,069 (216)

Discovery of Novel µ-Opioid Receptor Inverse Agonist from a Combinatorial Library of Tetrapeptides through Structure-Based Virtual Screening

open access: yesMolecules, 2019
Morphine, oxycodone, fentanyl, and other µ-opioid receptors (MOR) agonists have been used for decades in antinociceptive therapies. However, these drugs are associated with numerous side effects, such as euphoria, addiction, respiratory depression ...
Giulio Poli   +6 more
doaj   +1 more source

Isolated asthenozoospermia: What should we know? A narrative review of literature

open access: yesUroPrecision, EarlyView.
ABSTRACT Male infertility contributes to 20%–70% of infertile couple cases worldwide. One of the key challenges in this area is asthenozoospermia or reduced sperm motility. A particular subset, known as isolated asthenozoospermia (iASZ), in which low motility occurs without abnormalities in sperm count or shape, often goes unnoticed and is not well ...
Ahmed Eissa   +7 more
wiley   +1 more source

Influence of the hypothalamic arcuate nucleus on intraocular pressure and the role of opioid peptides.

open access: yesPLoS ONE, 2014
BackgroundAn opioid peptide neuron/humoral feedback regulation might be involved in changes of intraocular pressure (IOP). The aims of this study are to investigate the effects of arcuate nucleus (ARC) and opioid peptides on intraocular pressure (IOP ...
Ji Jin, Guo-xu Xu, Zhi-lan Yuan
doaj   +1 more source

The Long Arc of Substance Use Policy Innovation in Medicaid: Looking Back, Looking Forward

open access: yesThe Milbank Quarterly, EarlyView.
Policy Points The role of Medicaid in financing, organizing, and delivering substance use disorder (SUD) treatment has grown tremendously over time owing to expansions of eligibility and a push toward more uniformity in benefits. Current innovations in SUD treatment focus on expanding the delivery system to create a comprehensive continuum of care ...
BRENDAN SALONER
wiley   +1 more source

Peripheral Interaction of Resolvin D1 and E1 with Opioid Receptor Antagonists for Antinociception in Inflammatory Pain in Rats

open access: yesFrontiers in Molecular Neuroscience, 2017
Antinociceptive pathways are activated in the periphery in inflammatory pain, for instance resolvins and opioid peptides. Resolvins are biosynthesized from omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid ...
Beatrice Oehler   +7 more
doaj   +1 more source

Endotypes in Immune Mediated Drug Reactions: Present and Future of Relevant Biomarkers. An EAACI Task Force Report

open access: yesAllergy, EarlyView.
ABSTRACT Drug‐induced immune reactions are an important burden for patients and health systems. They can be classified into immediate‐drug hypersensitivity reactions (IDHRs) and delayed‐DHRs (DDHRs) based on their phenotype. Drugs do not always behave as allergens and need to bind to proteins, forming adducts.
C. Mayorga   +7 more
wiley   +1 more source

The Identification of Opioid Receptors and Peptide Precursors in Human DRG Neurons Expressing Pain-Signaling Molecules Confirms Their Potential as Analgesic Targets

open access: yesCells
The presence and function of the opioidergic system in sensory dorsal root ganglia (DRG) was demonstrated in various animal models of pain. To endorse recent functional and transcriptional evidence of opioid receptors in human DRG, this study compared ...
Shaaban A. Mousa   +6 more
doaj   +1 more source

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