Results 81 to 90 of about 30,638 (285)

Predicted functional alterations in colonic microbiota metabolism underlie ethanol consumption and preference behavior in mice

Alcohol, Clinical and Experimental Research, EarlyView.
Using a free‐choice ethanol model, we show that mice switched from a high‐sugar/butter diet to AIN93G standard diet consume and prefer more alcohol than mice maintained on AIN93G. 16S profiling and inferred metabolome revealed reduced amino acid metabolism, increased secondary bile acid pathways, and lower microbiota‐derived SCFAs and selected amino ...
Mírian Velten Mendes, Thiago Cavalcante Lima, Mariana Siqueira Amormino, Jamil Silvano de Oliveira, Fernanda Lima Alvarenga Barroso, Gaëlle Boudry, Renato Elias Moreira‐Júnior, Ana Lúcia Brunialti‐Godard   +7 more
wiley   +1 more source

Differential behaviour of LPH‐(61–91)‐peptide in different model systems: Comparison of the opioid activities of LPH‐(61–91)‐peptide and its fragments [PDF]

, 1977
András Z. Rónai, László Gráf, József I. Székely, Zsuzsa Dunai-Kovàcs, S. Bajusz   +4 more
openalex   +1 more source

Activation of peripheral NOP receptors reduces periorbital mechanical allodynia evoked by CGRP in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro, Pietro Pola, Michela Argentieri, Alessia Frezza, Matilde Marini, Francesco De Logu, Valentina Albanese, Marie Soukupova, Davide Malfacini, Nurulain T. Zaveri, Romina Nassini, Dane D. Jensen, Pierangelo Geppetti, Girolamo Calò, Chiara Ruzza   +14 more
wiley   +1 more source

Nociceptin/Orphanin FQ Opioid Peptide-Receptor Expression in the Endometriosis-Associated Nerve Fibers-Possible Treatment Option? [PDF]

Cells, 2023
Guan Q, Velho RV, Jordan A, Pommer S, Radde I, Sehouli J, Mechsner S.   +6 more
europepmc   +1 more source

Endogenous opioid peptides and the control of pain [PDF]

, 1979
H. W. Kosterlitz
openalex   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Delta Opioid Peptide Targets Brain Microvascular Endothelial Cells Reducing Apoptosis to Relieve Hypoxia-Ischemic/Reperfusion Injury. [PDF]

Pharmaceutics, 2022
Zhang R, Chen M, Deng Z, Kong L, Shen B, Zhang L.   +5 more
europepmc   +1 more source

Discovery of Novel µ-Opioid Receptor Inverse Agonist from a Combinatorial Library of Tetrapeptides through Structure-Based Virtual Screening

Molecules, 2019
Morphine, oxycodone, fentanyl, and other µ-opioid receptors (MOR) agonists have been used for decades in antinociceptive therapies. However, these drugs are associated with numerous side effects, such as euphoria, addiction, respiratory depression ...
Giulio Poli, Marilisa Pia Dimmito, Adriano Mollica, Gokhan Zengin, Sandor Benyhe, Ferenc Zador, Azzurra Stefanucci   +6 more
doaj   +1 more source

Troriluzole attenuates opioid intake, reinforcing efficacy, seeking behaviours, physical dependence and antinociceptive tolerance in rats

British Journal of Pharmacology, EarlyView.
Background and Purpose Riluzole, approved for amyotrophic lateral sclerosis (ALS), has a glutamate‐modulating profile favourable for mitigating opioid addiction. It reduces neuronal glutamate release and enhances glutamate reuptake, offering advantages over agents that only increase glutamate reuptake.
Ewa Galaj, Saadet Inan, Guo‐Hua Bi, Sonita Wiah, George Adamson, Allen B. Reitz, Zheng‐Xiong Xi, Scott M. Rawls   +7 more
wiley   +1 more source

Cardiovascular and renal effects of novel nonpeptide nociceptin opioid peptide receptor agonists. [PDF]

Br J Pharmacol, 2022
Denys IB, Gao J, Sutphen JC, Zaveri NT, Kapusta DR.   +4 more
europepmc   +1 more source