Results 81 to 90 of about 52,140 (266)
Current and novel biomarkers in cardiogenic shock
European Journal of Heart Failure, EarlyView.A summary of current and novel biomarkers and their potential stages of release in cardiogenic shock. The diagram illustrates the proposed release of the biomarkers during the different stages of cardiogenic shock: progression from cardiac dysfunction/stress, through to inflammation and end‐organ dysfunction.
Victor Galusko +5 more
wiley +1 more source
Lipid- and sugar-modified endomorphins: Novel targets for the treatment of neuropathic pain
Frontiers in Pharmacology, 2013 Endomorphins are endogenous opioid peptides that cause potent antinociception in rodent models of acute and neuropathic pain with less undesirable side effects than opioid alkaloids.
Pegah eVaramini +2 more
doaj +1 more source
Discovering heterogeneous subpopulations for fine-grained analysis of opioid use and opioid use disorders [PDF]
arXiv, 2018 The opioid epidemic in the United States claims over 40,000 lives per year, and it is estimated that well over two million Americans have an opioid use disorder. Over-prescription and misuse of prescription opioids play an important role in the epidemic.
arxiv
Isolation and amino acid sequence analysis of a 4,000-dalton dynorphin from porcine pituitary [PDF]
, 1982 A 4,000-dalton dynorphin was isolated from porcine pituitary. It has 32 amino acids (Mr = 3,986), with the previously described heptadecapeptide (now called dynorphin A) at its amino terminus and a related tridecapeptide, dynorphin B, at its carboxyl ...
Fischli, Walter +3 more
core
Learning Protein Dynamics with Metastable Switching Systems [PDF]
arXiv, 2016 We introduce a machine learning approach for extracting fine-grained representations of protein evolution from molecular dynamics datasets. Metastable switching linear dynamical systems extend standard switching models with a physically-inspired stability constraint.
arxiv
Training self-supervised peptide sequence models on artificially chopped proteins [PDF]
arXiv, 2022 Representation learning for proteins has primarily focused on the global understanding of protein sequences regardless of their length. However, shorter proteins (known as peptides) take on distinct structures and functions compared to their longer counterparts. Unfortunately, there are not as many naturally occurring peptides available to be sequenced
arxiv
ELECTROPHORESIS, EarlyView.ABSTRACT This review provides an in‐depth exploration of capillary electrophoresis–mass spectrometry (CE–MS) in biomolecular research from 2020 to 2024. CE–MS emerges as a versatile and powerful tool due to its numerous advantages, facilitating the analysis of various biomolecules, including proteins, peptides, oligonucleotides, and other metabolites ...
Laura Pont +2 more
wiley +1 more source
BCM-7: Opioid-like Peptide with Potential Role in Disease Mechanisms
MoleculesBovine milk is an essential supplement due to its rich energy- and nutrient-rich qualities. Caseins constitute the vast majority of the proteins in milk.
Ecem Bolat +8 more
doaj +1 more source
Cell Transplantation, 2006 We have reported that transplantation of adrenal medullary chromaffin cells that release endogenous opioid peptides into pain modulatory regions in the CNS produce significant antinociceptive effects in patients with terminal cancer pain.
Ikuko Sugaya +3 more
doaj +1 more source
Exploration, EarlyView.The discovery of the glymphatic system has opened up a pathway for drug delivery to the brain by circumventing the blood‐brain barrier, which can effectively improve drug utilization. The methods of drug delivery through the glymphatic system include intrathecal injection, intranasal injection, and delivery through the meningeal lymphatic vessels.
Xiang Wang +7 more
wiley +1 more source