Results 291 to 300 of about 2,594,817 (409)

Population Pharmacokinetics and Transfer of Gabapentin When Used as a Pain Adjunct for Cesarean Deliveries

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 551-560, March 2025.
ABSTRACT Enhanced Recovery After Surgery (ERAS) protocols for cesarean deliveries (CDs) utilize multimodal pain management strategies that often include gabapentin. While gabapentin is excreted in breast milk, its pharmacokinetics in immediately postpartum lactating women are not known. This observational pharmacokinetic study (NCT05099484) enrolled 21
Rebecca Silvola, Aislinn O'Kane, Michael Heathman, Hannah Marotta, Hayley Trussel, Bobbie Ray, Shelley Dowden, Andrea R. Masters, David M. Haas, Sara K. Quinney   +9 more
wiley   +1 more source

Evidencing the role of a conserved polar signaling channel in the activation mechanism of the μ-opioid receptor. [PDF]

Comput Struct Biotechnol J
Sarkar A, Dvorácskó S, Lipinszki Z, Mitra A, Harmati M, Buzás K, Borics A.   +6 more
europepmc   +1 more source

Illicit Drug‐Derived Volatile Organic Compounds as Markers for Application in Noncontact Detection Technology

The Chemical Record, EarlyView.
This review highlights the characteristic odor markers of illicit drugs, emphasizing volatile markers from both natural and synthetic sources, and explores the shift from canine‐based detection to emerging noncontact sensing technologies. Illicit drug use remains a global concern, requiring effective detection methods to counter evolving concealment ...
Minwoo Kim, Solpa Lee, Anmo J. Kim, Cong Wang, Yongwoo Jang   +4 more
wiley   +1 more source

Targeting the kappa opioid receptor for analgesia and antitumour effects. [PDF]

Br J Anaesth
Lambert DG, Mincer JS.
europepmc   +1 more source

Opioids and Their Receptors [PDF]

, 2020
openaire   +1 more source

Remimazolam Enables Faster Sedation Induction and Recovery Compared With Midazolam in Diagnostic Upper Gastrointestinal Endoscopy: A Multicenter Randomized Controlled Trial

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background and Aims Remimazolam, a new ultra‐short‐acting benzodiazepine, is a safe and effective option for procedural sedation. Nevertheless, to date, no study has directly compared remimazolam and midazolam in diagnostic upper gastrointestinal endoscopy. This study aimed to evaluate the efficacy and safety of remimazolam compared with those
Yehyun Park, Jun Kyu Lee, Kwang Hyuck Lee, Taejun Kim, Sun Hyung Kang, Dong‐Won Ahn, Sung Bum Kim, Seong‐Jung Kim   +7 more
wiley   +1 more source

Exploring Pharmacokinetic interactions between SHR8554, a µ-opioid receptor biased agonist, and Itraconazole in healthy Chinese subjects. [PDF]

Sci Rep
Huang L, Jiang H, Huang Y, Li J.
europepmc   +1 more source

Synthesis, Binding Affinity, and Functional in Vitro Activity of 3-Benzylaminomorphinan and 3-Benzylaminomorphine Ligands at Opioid Receptors

, 2012
John L. Neumeyer, Bin Zhang, Tangzhi Zhang, Anna W. Sromek, Brian I. Knapp, Dana J. Cohen, Jean M. Bidlack   +6 more
openalex   +1 more source

Effect of butorphanol in combination with xylazine during castration of calves: A randomised trial under field conditions

Veterinary Record, EarlyView.
Abstract Background In horses, cats and dogs, the opioid butorphanol has been proven effective in management of visceral pain and for peri‐ and postoperative pain relief. The aim of this study was to evaluate physiological responses and indicators of noxious stimuli when adding butorphanol to xylazine for sedation of bull calves during surgical ...
Axel Sannö, Lovisa Snygg, Maja Wiklund, Görel Nyman   +3 more
wiley   +1 more source