Results 291 to 300 of about 2,542,870 (405)

Dexmedetomidine as a Ropivacaine Adjuvant in a Thoracic Paravertebral Block Combined With an Erector Spinae Plane Block for Improving Early Quality of Recovery After Transapical Transcatheter Aortic Valve Implantation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The study aimed to investigate the effectiveness of dexmedetomidine (Dex) as an adjuvant for ropivacaine in a thoracic paravertebral block (TPVB) combined with an erector spinae plane block (ESPB) for improving early quality of recovery and postoperative pain after transapical transcatheter aortic valve implantation (TAVI).
Gui‐Ling Dong, Rong‐En Qiu, Chen‐Zhan Xu   +2 more
wiley   +1 more source

Mu Opioid Receptor Positive Allosteric Modulator BMS-986122 Confers Agonist-Dependent G Protein Subtype Signaling Bias. [PDF]

Biochemistry
Grieble GM, Knapp BI, Bidlack JM.
europepmc   +1 more source

Landscape of informed consent practices and challenges in point‐of‐care clinical trials

Learning Health Systems, EarlyView.
Abstract Point‐of‐care trials, an approach to trial design that assesses medical product effectiveness while fully integrating research and care, represent a promising opportunity to generate practically relevant evidence efficiently for priority disease areas.
Caleigh Propes, Trevan Locke, Rachele Hendricks‐Sturrup   +2 more
wiley   +1 more source

Aligning forces to accelerate healthcare transformation: Insights from the UPMC learning community

Learning Health Systems, EarlyView.
Abstract Introduction To accelerate transformation toward value‐based, equitable care, health systems need a viable approach for engaging and aligning multiple stakeholders to promote innovation. Building and sustaining learning communities offers one possible solution.
Diane Holder, Donna Keyser, Jane Kogan, Matthew O. Hurford, John Lovelace, James Schuster   +5 more
wiley   +1 more source

Kappa opioid receptor internalisation-induced p38 nuclear translocation suppresses glioma progression. [PDF]

Br J Anaesth
Li Y, Wang W, She H, Cui Z, Liu Z, Yang H, Zhang J, Zhou X, Bao D, Yao Y, Luo S, Cai R, Shi Y, Ping YF, Mao Q.   +14 more
europepmc   +1 more source

A learning health system model for addressing substance use: Denver Health Center for Addiction Medicine

Learning Health Systems, EarlyView.
Abstract Introduction Substance use disorders (SUDs) continue to place heavy burdens on patients, health systems, and communities. Rapidly evolving treatment for SUDs requires health systems that can efficiently and effectively assess data and integrate evidence to practice.
Emily Bacon, Laura J. Podewils, Brooke Bender, Joshua Blum, Christian Thurstone, Alia Al‐Tayyib, John Mills, Alexandra R. Tillman, Judith Shlay   +8 more
wiley   +1 more source

Structural basis of μ-opioid receptor targeting by a nanobody antagonist. [PDF]

Nat Commun
Yu J, Kumar A, Zhang X, Martin C, Van Holsbeeck K, Raia P, Koehl A, Laeremans T, Steyaert J, Manglik A, Ballet S, Boland A, Stoeber M.   +12 more
europepmc   +1 more source

Inhibitory Effects of NaCl and Guanyl-5'yl-imidodiphosphate (GppNHp) on (3H)Naloxone Binding to .KAPPA.-Opioid Receptors in Guinea Pig Cerebellum.

, 1993
Kumiko Ishige, M Makimura, Yukako Ιtο, Y. Murakoshi   +3 more
openalex   +2 more sources

Cyclical medication management interventions in health care settings: A systematic review

Learning Health Systems, EarlyView.
Abstract Introduction It is estimated that one in 30 patients experiences at least one preventable medication‐related harm while receiving care. Cyclical medicine improvement interventions, where health systems continuously collect data, implement prescribing/dispensing interventions, review outcomes, and revise the intervention, have demonstrated ...
Isabelle Meulenbroeks, Crisostomo Mercado, Rachel Urwin, Karla Seaman, Anna Kelly, Osman Qadri, Johanna Westbrook I.   +6 more
wiley   +1 more source

Disentangling informing participants from obtaining their consent

Learning Health Systems, EarlyView.
Abstract Introduction Pragmatic clinical trials conducted in the context of routine care frequently satisfy the regulatory criteria for a waiver of research consent. When they do, investigators and Institutional Review Boards might assume that there is no reason to communicate any information regarding the study to participants.
Patricia Pearl O'Rourke, Joseph Ali, Judith Carrithers, David Magnus, Benjamin S. Wilfond, Sheana Bull, Laura M. Dember, Gail D'Onofrio, Julie Goldman, P. Michael Ho, Edward R. Melnick, Karen L. Staman, James A. Tulsky, Miguel A. Vazquez, Angelo Volandes, David Wendler   +15 more
wiley   +1 more source