Results 301 to 310 of about 2,542,870 (405)

Endogenous opioid receptor system mediates costly altruism in the human brain. [PDF]

Commun Biol
Chen J, Putkinen V, Seppälä K, Hirvonen J, Ioumpa K, Gazzola V, Keysers C, Nummenmaa L.   +7 more
europepmc   +1 more source

A framework for health systems to assess and prioritize participation in pragmatic clinical trials

Learning Health Systems, EarlyView.
Abstract Introduction Pragmatic clinical trials (PCTs) are frequently embedded within settings in which patients receive their routine clinical care. The health care institutions that deliver routine clinical care must therefore decide how they prioritize PCTs in comparison to other institutional priorities. Yet no formal guidance yet exists to support
Stephanie R. Morain, Matthew W. Semler, Jonathan D. Casey   +2 more
wiley   +1 more source

Exploring substitution effects on the potential dominant conformations of NBF derivatives leading to functional conversion at the mu opioid receptor. [PDF]

RSC Chem Biol
Li E, Reda A, Ma H, Woodard S, Gillespie JC, Selley DE, Dewey WL, Pagare PP, Zhang Y.   +8 more
europepmc   +1 more source

Disruption of the kappa -opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa -agonist U-50,488H and attenuates morphine withdrawal

, 1998
Frédéric Simonin, Olga Valverde, Claire Smadja, Susan Slowe, Ian Kitchen, Andrée Dierich, Marianne Le Meur, Bernárd P. Roques, Rafael Maldonado, Brigitte L. Kieffer   +9 more
openalex   +1 more source

Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR Review 10

British Journal of Pharmacology, 2014
Wakako Fujita, I. Gomes, L. Devi
semanticscholar   +1 more source

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, EarlyView.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

Effects of Biased Analogues of the Kappa Opioid Receptor Agonist, U50,488, in Preclinical Models of Pain and Side Effects. [PDF]

Molecules
van de Wetering R, Vu LY, Kornberger LD, Luo D, Scouller B, Hong S, Paton K, Prisinzano TE, Kivell BM.   +8 more
europepmc   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

A New Trick of Old Dogs: Can Kappa Opioid Receptor Antagonist Properties of Antidepressants Assist in Treating Treatment-Resistant Depression (TRD)? [PDF]

Pharmaceuticals (Basel)
Schreiber S, Keidan L, Pick CG.
europepmc   +1 more source

kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system.

, 1995
Frédéric Simonin, Claire Gavériaux‐Ruff, Katia Befort, Harald Matthes, Béatrice Lannes, Gabriele Micheletti, Marie‐Geneviève Mattéi, G Charron, Bertrand Bloch, Brigitte L. Kieffer   +9 more
openalex   +1 more source