Results 311 to 320 of about 2,577,172 (407)

Carfentanil stabilizes µ opioid receptor conformations that are ultra-efficient in inhibiting cAMP, resistant to naloxone or nalmefene but sensitive to naltrexone. [PDF]

Arch Toxicol
Endt F, Guo T, Steinritz D, Amend N, Gudermann T, Breit A.   +5 more
europepmc   +1 more source

Extraordinary potency of a novel delta opioid receptor agonist is due in part to increased efficacy

, 1997
Thomas H. Kramer, Hubert Bartosz-Bechowski, Peg Davis, Victor J. Hruby, Frank Porreca   +4 more
openalex   +1 more source

Opioid consumption after lower limb amputation in Medicare beneficiaries

PM&R, EarlyView.
Abstract Background Despite targeted national quality improvement initiatives, opioid prescription and use patterns after lower limb amputation are not well studied. Objective To determine risk factors associated with extended opioid use and rates of high‐risk opioid prescribing after lower limb amputation. Design and setting A retrospective population‐
Alexander N. Khouri, Nishant Ganesh Kumar, Hsou‐Mei Hu, Maryam Yazdanfar, Jennifer F. Waljee, Theodore A. Kung   +5 more
wiley   +1 more source

The Utility of Cyclodextrin for Countering μ-Opioid Receptor Drug Overdoses. [PDF]

ACS Cent Sci
Ogawa N.
europepmc   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Developing predictive models for µ opioid receptor binding using machine learning and deep learning techniques. [PDF]

Exp Biol Med (Maywood)
Liu J, Li J, Li Z, Dong F, Guo W, Ge W, Patterson TA, Hong H.   +7 more
europepmc   +1 more source

Erinacine E as a Kappa Opioid Receptor Agonist and Its New Analogs from a Basidiomycete, Hericium ramosum.

, 1998
Toshiyuki Saito, FUKUMATSU AOKI, Hideo Hirai, TAISUKE INAGAKI, YASUE MATSUNAGA, TATSUO SAKAKIBARA, Shinichi Sakemi, YUMIKO SUZUKI, Shuzo Watanabe, Osamu Suga, Tetsujo Sujaku, Adam A. Smogowicz, S.J. Truesdell, John W. Wong, Atsushi Nagahisa, Yasuhiro Kojima, Nakao Kojima   +16 more
openalex   +2 more sources

Population Pharmacokinetics and Transfer of Gabapentin When Used as a Pain Adjunct for Cesarean Deliveries

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 551-560, March 2025.
ABSTRACT Enhanced Recovery After Surgery (ERAS) protocols for cesarean deliveries (CDs) utilize multimodal pain management strategies that often include gabapentin. While gabapentin is excreted in breast milk, its pharmacokinetics in immediately postpartum lactating women are not known. This observational pharmacokinetic study (NCT05099484) enrolled 21
Rebecca Silvola, Aislinn O'Kane, Michael Heathman, Hannah Marotta, Hayley Trussel, Bobbie Ray, Shelley Dowden, Andrea R. Masters, David M. Haas, Sara K. Quinney   +9 more
wiley   +1 more source

A new pathway for neuroprotection against tau hyperphosphorylation via δ-opioid receptor initiated inhibition of CDK5 and AMPK signaling. [PDF]

Front Aging Neurosci
Li J, Xu Y, Balboni G, Xia Y.
europepmc   +1 more source

Biomimetic Carbon‐Based Nanomaterials: From Design Strategies to Next‐Generation Biosensing and Theranostic Applications

Small, EarlyView.
This review summarizes biomimetic design strategies for carbon‐based nanomaterials, including graphene oxide, carbon dots, and nanotubes, highlighting their tunable physicochemical properties for advanced biosensing and theranostic systems. Defined approaches such as DNA templating, peptide‐assisted assembly, and fluorescence switching are discussed ...
Marzieh Ramezani Farani, Ashkan Zandi, Fatemeh Shojaeian, Mingzhen Zhang, Danial Khorsandi, Fariba Mollarasouli, Iraj Alipourfard, Amin Farahani, Yu Jung Choi, Heemin Kang, Yun Suk Huh   +10 more
wiley   +1 more source