Results 311 to 320 of about 2,594,817 (409)

Impact of renal impairment on the pharmacokinetic profile of intravenous difelikefalin, a kappa opioid receptor agonist for the treatment of pruritus

Robert H. Spencer, Patrick K. Noonan, Thomas Marbury, Frédérique Menzaghi   +3 more
openalex   +1 more source

Comparative Impact of NSAIDs Versus Acetaminophen on Mortality in Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: A Retrospective Cohort Study of 2484 Patients From a Nationwide Inpatient Database

The Journal of Dermatology, EarlyView.
ABSTRACT Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe and life‐threatening mucocutaneous disorders, primarily triggered by medications. Despite the frequent need for antipyretic and analgesic therapy, the impact of nonsteroidal anti‐inflammatory drugs (NSAIDs) and acetaminophen on clinical outcomes in patients with SJS/
Rino Toyoshima, Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi, Natsumi Hama, Riichiro Abe, Hideo Yasunaga, Shinichi Sato, Sayaka Shibata   +8 more
wiley   +1 more source

Role of β-Arrestin 2 in the antinociceptive and side effect profile of morphine and the novel mu opioid receptor agonists, kurkinorin and kurkinol. [PDF]

Neuropsychopharmacology
van de Wetering R, Alder AF, Biggerstaff A, Sellen K, Luo D, Crowley RS, Prisinzano TE, Kivell BM.   +7 more
europepmc   +1 more source

Factors Influencing Agonist Potency and Selectivity for the Opioid δ Receptor Are Revealed in Structure−Activity Relationship Studies of the 4-[(N-Substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides

, 2001
James B. Thomas, Xavier M. Herault, Richard B. Rothman, Robert N. Atkinson, Jason P. Burgess, S. Wayne Mascarella, Christina M. Dersch, Heng Xu, J.L. Flippen-Anderson, Clifford George, F. Ivy Carroll   +10 more
openalex   +1 more source

Differences in Risk Factors for Severe Preeclampsia and HELLP Syndrome in Singleton Versus Twin Pregnancies: A Population‐Based Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To examine whether the associations between pre‐pregnancy risk factors and severe preeclampsia/eclampsia (SPE) and/or HELLP syndrome differ between singleton and twin pregnancies. Design A population‐based retrospective cohort study. Setting British Columbia (BC), Canada.
Mackenzie Campbell, Johanna Koegl, Jeffrey N. Bone, Sofia Nicolls, Janet Lyons, Chantal Mayer, Kenneth I Lim, Julie Van Schalkwyk, K. S. Joseph, Sarka Lisonkova, the ORQA group, A. Christoffersen‐Deb, S. Derikvand, S. John, L. Richter, M. Rougerie, Y. Sabr, M. Vidler   +17 more
wiley   +1 more source

Childhood family environment and μ-opioid receptor availability in vivo in adulthood. [PDF]

Neuropsychopharmacology
Saarinen A, Tuominen L, Puttonen S, Raitakari O, Keltikangas-Järvinen L, Hietala J.   +5 more
europepmc   +1 more source

Recovery After Transcervical Fibroid Ablation Versus Minimally Invasive Myomectomy for Symptomatic Uterine Fibroids: A Randomised Controlled Trial

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To evaluate early recovery outcomes with transcervical fibroid ablation (TFA) compared to minimally invasive myomectomy (MIM) in women with symptomatic uterine fibroids. Design Randomised controlled trial. Setting Tübingen University Hospital (Tübingen, Germany).
Felix Neis, Bernhard Kraemer, Armin Bauer, Tjeerd Dijkstra, Sabine Matovina, Annika Rohner, Sara Y. Brucker   +6 more
wiley   +1 more source

Effects of social isolation on locus coeruleus opioid receptor expression and affective behavior. [PDF]

Neurobiol Stress
Tkaczynski J, Riser J, Patel M, Shellenbarger N, Park J, Manvich D, Chandler DJ.   +6 more
europepmc   +1 more source

“It's such a terrible drug”: Narratives of fentanyl dealers amid the opioid overdose crisis

Criminology, EarlyView.
Abstract The fentanyl‐fueled overdose crisis is historically lethal, yet the voices of those who sell fentanyl remain understudied. While research has focused extensively on people who use drugs (PWUD), the perspectives of people who sell fentanyl (PWSF) are largely absent from academic and policy discussions. This study draws on 87 in‐depth interviews
Brittney M. Schwehr, Sandra M. Bucerius
wiley   +1 more source

Biased Opioid Receptor Agonists: Balancing Analgesic Efficacy and Side-Effect Profiles. [PDF]

Int J Mol Sci
Ju J, Li Z, Liu J, Peng X, Gao F.
europepmc   +1 more source