Results 81 to 90 of about 1,391,378 (297)

Methadone for Cancer Pain

Palliative Care, 2010
Pain is one of the most common and incapacitating symptoms experienced by patients with advanced cancer. Methadone is a potent opioid with strong affinity for the µ opioid receptor. In addition to being a potent µ opioid receptor ligand, methadone blocks
Eric E. Prommer
doaj   +2 more sources

Heteromerization Modulates mu Opioid Receptor Functional Properties in vivo

Frontiers in Pharmacology, 2018
Mu opioid receptors modulate a large number of physiological functions. They are in particular involved in the control of pain perception and reward properties.
Muzeyyen Ugur, Lyes Derouiche, Dominique Massotte   +2 more
doaj   +1 more source

GRKs as Key Modulators of Opioid Receptor Function

Cells, 2020
Understanding the link between agonist-induced phosphorylation of the mu-opioid receptor (MOR) and the associated physiological effects is critical for the development of novel analgesic drugs and is particularly important for understanding the ...
Laura Lemel, J Robert Lane, Meritxell Canals   +2 more
doaj   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice

Translational Psychiatry
Mood and anxiety disorders are leading causes of disability worldwide and are major contributors to the global burden of diseases. Neuropeptides, such as oxytocin and opioid peptides, are important for emotion regulation.
Khalin E. Nisbett, Leandro F. Vendruscolo, George F. Koob   +2 more
doaj   +1 more source

Proto‐Panic Modulation by Caffeine‐Proteinoid Complexes

Journal of Applied Polymer Science, EarlyView.
Caffeine–proteinoid microspheres synthesized by thermal polymerization exhibit compartmentalized drug loading with encapsulation efficiencies of 61%–82% and triphasic release kinetics. Electrochemical monitoring reveals multi‐scale oscillatory dynamics consistent with chaotic and damped harmonic behavior, while Boolean logic operations demonstrate ...
Panagiotis Mougkogiannis, Andrew Adamatzky   +1 more
wiley   +1 more source

Effects of Central Administration of Opioid Peptides, Vasotocin, Mesotocin, and Corticotrophin-Releasing Factor on Water Intake in Chicks

The Journal of Poultry Science
Freedom from thirst is an undeniable requirement of the poultry industry. However, the regulatory mechanisms underlying water intake in chicks are not yet fully understood.
Yuhui Zhang, Kaoruko Murata, Junya Takegaki, Takaoki Saneyasu, Kazuhisa Honda   +4 more
doaj   +1 more source

Effects of Loperamide on Mechanical Allodynia Induced by Herpes Simplex Virus Type-1 in Mice

Journal of Pharmacological Sciences, 2007
In the present study, we investigated whether the peripherally acting µ-opioid receptor agonist loperamide would inhibit allodynia in the non-inflamed dermatome of mice with herpetic pain.
Atsushi Sasaki, Yasutaka Nakashima, Ichiro Takasaki, Tsugunobu Andoh, Kimiyasu Shiraki, Yasushi Kuraishi   +5 more
doaj   +1 more source

NOCICEPTIN/ORPHANIN FQ RECEPTOR LIGANDS: PHARMACOLOGICAL STUDIES [PDF]

, 2009
The neuropeptide nociceptin/orphanin FQ (N/OFQ) selectively binds and activates the N/OFQ peptide (NOP) receptor. At cellular level N/OFQ inhibits cAMP accumulation and Ca2+ conductance and stimulates K+ currents.
Fischetti, Carmela, Carmela Fischetti (7591079)   +1 more
core  

Influence of Psychiatric Comorbidities on Postoperative Outcomes Following Pediatric Medial Patellofemoral Ligament Reconstruction

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To compare postoperative complications, rehabilitation outcomes, and health care utilization in children undergoing primary medial patellofemoral ligament reconstruction for patellofemoral instability with and without a pre‐existing mental illness. Methods The TriNetX U.S.
Haad A. Arif, Pearce Lane, Shamar T. Elliott, Amit Momaya, Kevin A. Williams   +4 more
wiley   +1 more source