Results 191 to 200 of about 2,911,994 (243)
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Opioid receptor polymorphismsand opioid abuse
Pharmacogenomics, 2002The sequencing of the human genome is only the first step. The next step is to determine the function of these genes and in particular, how alterations in specific genes lead to major human disorders. Many laboratories are now focusing on identifying and characterizing single nucleotide polymorphisms (SNPs), to determine which correlate in frequency ...
Nancy M, Lee, Andrew P, Smith
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NeuroMolecular Medicine, 2004
Opioid receptors are regulated by multiple mechanisms, which are believed to contribute to the physiological plasticity of the endogenous opioid system in response to natural neuropeptides, as well as clinically relevant opiate drugs. Considerable progress has been made in elucidating molecular and cellular mechanisms of opioid receptor regulation. The
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Opioid receptors are regulated by multiple mechanisms, which are believed to contribute to the physiological plasticity of the endogenous opioid system in response to natural neuropeptides, as well as clinically relevant opiate drugs. Considerable progress has been made in elucidating molecular and cellular mechanisms of opioid receptor regulation. The
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Current Protocols in Pharmacology, 1998
AbstractOpioid receptors mediate the pharmacologic actions of morphine‐like analgesics, a class of drugs that are important clinical agents which are also widely abused socially as a result of their euphorogenic and addictive properties. Cloning of the opioid receptors has confirmed the original postulate that there are only three classes of opioid ...
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AbstractOpioid receptors mediate the pharmacologic actions of morphine‐like analgesics, a class of drugs that are important clinical agents which are also widely abused socially as a result of their euphorogenic and addictive properties. Cloning of the opioid receptors has confirmed the original postulate that there are only three classes of opioid ...
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2021
Opioid receptors, beyond their involvement in pain transmission, play a number of relevant physiological roles in the central nervous system and in peripheral organs. Opioid receptors can be considered a crossroads where endogenous opioid peptides and foreign opioids and opiates meet the cell and transmit their messages to another vast array of ...
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Opioid receptors, beyond their involvement in pain transmission, play a number of relevant physiological roles in the central nervous system and in peripheral organs. Opioid receptors can be considered a crossroads where endogenous opioid peptides and foreign opioids and opiates meet the cell and transmit their messages to another vast array of ...
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Opioid receptors signaling network
Journal of Cell Communication and Signaling, 2021Opioid receptors belong to the class A G-protein-coupled receptors and are activated by alkaloid opiates such as morphine, and endogenous ligands such as endorphins and enkephalins. Opioid receptors are widely distributed in the human body and are involved in numerous physiological processes through three major classical opioid receptor subtypes; the ...
Lathika Gopalakrishnan +6 more
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Opioid receptors and endogenous opioid peptides
Medicinal Research Reviews, 1991The field to be reviewed is now 16 years old and is based on knowledge dating back centuries. It is therefore evident that an exhaustive review is impossible. The author plans to discuss areas likely to be of interest to the readers of this journal.
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1990
Abstract Evidence for the heterogeneity of opioid receptor sites in the CNS has been provided by a variety of studies. At least three classes of binding sites have been identified and designated as μ (morphine), δ (enkephalin) and x (dynorphin).
Catherine D Demoliou-mason +1 more
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Abstract Evidence for the heterogeneity of opioid receptor sites in the CNS has been provided by a variety of studies. At least three classes of binding sites have been identified and designated as μ (morphine), δ (enkephalin) and x (dynorphin).
Catherine D Demoliou-mason +1 more
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OPIOID RECEPTOR SIGNALLING MECHANISMS
Clinical and Experimental Pharmacology and Physiology, 19991. Three pharmacological types of opioid receptors, μ, δ and κ, and their corresponding genes have been identified. Although other types of opioid receptors have been suggested, their existence has not been established unequivocally. A fourth opioid receptor, ORL1, which is genetically closely related to the others, has also been isolated.
M, Connor, M D, Christie
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The Journal of Steroid Biochemistry and Molecular Biology, 1994
The genomic mode of action is believed to represent the predominant effect of a steroid hormone. Recently, however, rapidly manifesting, non-genomic effects have also been observed. These are mediated mostly by allosteric interaction of a steroid with heterologous target structures such as membrane receptors, a prototype example being the GABAA.
S, Schwarz, P, Pohl
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The genomic mode of action is believed to represent the predominant effect of a steroid hormone. Recently, however, rapidly manifesting, non-genomic effects have also been observed. These are mediated mostly by allosteric interaction of a steroid with heterologous target structures such as membrane receptors, a prototype example being the GABAA.
S, Schwarz, P, Pohl
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