Results 171 to 180 of about 6,986 (221)

Opioid research in the time of the opioid crisis

British Journal of Pharmacology, 2023
LINKED ARTICLESThis article is part of a themed issue on Advances in Opioid Pharmacology at the Time of the Opioid Epidemic. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v180.7 ...
John R, Traynor, Jose A, Moron
openaire   +2 more sources

Opioids

Neurologic Clinics, 1993
The major clinical uses for opioids are to control pain, suppress cough, and to treat diarrhea. These drugs, however, have the potential for abuse. It is postulated that the significant mood-altering effects of opioids combined with their pharmacology, in which tolerance and physical and psychological dependence occur, account for their abuse liability.
openaire   +2 more sources

Opioid and anti‐opioid peptides

Fundamental & Clinical Pharmacology, 1995
Summary— The numerous endogenous opioid peptides (β‐endorphin, enkephalins, dynorphins…) and the exogenous opioids (such as morphine) exert their effects through the activation of receptors belonging to four main types: μ, Δ, k and ε. Opioidergic neurones and opioid receptors are largely distributed centrally and peripherally. It is thus not surprising
openaire   +2 more sources

Opioid receptor polymorphismsand opioid abuse

Pharmacogenomics, 2002
The sequencing of the human genome is only the first step. The next step is to determine the function of these genes and in particular, how alterations in specific genes lead to major human disorders. Many laboratories are now focusing on identifying and characterizing single nucleotide polymorphisms (SNPs), to determine which correlate in frequency ...
Nancy M, Lee, Andrew P, Smith
openaire   +2 more sources

‘Opioid’, opioids, pain, language and communication

Anaesthesia and Intensive Care, 2022
Over the last decades public discussion of opioids has changed radically. Opioid was once a word largely restricted to professional medical and pharmacological use for the treatment and management of pain. But propelled by the rapidly growing international wave of opioid use and overuse, it is now part of a much wider public discussion that covers more
openaire   +4 more sources

Opioids, opioid receptors, and the immune response

Drug and Alcohol Dependence, 2001
It is now clear that opioid receptors participate in the function of the cells of the immune system, and evidence suggests that opioids modulate both innate and acquired immune responses. We review literature here which establishes that mu-, kappa-, and delta-opioid compounds alter resistance to a variety of infectious agents, including the Human ...
L, McCarthy, M, Wetzel, J K, Sliker, T K, Eisenstein, T J, Rogers   +4 more
openaire   +2 more sources

Opioids and Opioid Receptors in Peripheral Tissues

Scandinavian Journal of Gastroenterology, 1987
Opioid peptides belonging to the enkephalin, beta-endorphin or dynorphin family, acting on specific opiate receptors may be found in peripheral tissues. Enkephalins have a widespread peripheral distribution, while beta-endorphin and dynorphin may be found locally in the enteric nervous system.
T, Hedner, J, Cassuto
openaire   +2 more sources

Non-opioid actions of opioid peptides

Life Sciences, 2004
Beside the well known actions of opioid peptides on mu-, delta- and kappa-opioid receptors, increasing amount of pharmacological and biochemical evidence has recently been published about non-opioid actions of various opioid peptides. These effects are not abolished by naloxone treatments.
Mária, Wollemann, Sándor, Benyhe
openaire   +2 more sources

OPIOIDS AND PAIN

Clinical and Experimental Pharmacology and Physiology, 1995
SUMMARY1. The central nervous system in mammals is able to react to painful stimuli at many levels that are involved in transmission, modulation and sensation of pain. Endogenous opioid peptides and their receptors are located at key points in pain pathways, and response to pain can be modulated by local application of opioids at many sites. Mechanisms
openaire   +4 more sources

Opioid genetics in the context of opioid switching

Current Opinion in Supportive & Palliative Care, 2012
On a population level, there is no difference in terms of efficacy or side-effects between any of the strong opioids. On an individual level, however, there is marked variation in response to opioids. This review presents some of the recent advances in opioid pharmacogenetic studies.A growing number of genes have been studied in a number of different ...
Joanne, Droney, Julia, Riley, Joy, Ross
openaire   +2 more sources