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Description and evaluation of a national humanitarian opioid poisoning education and naloxone distribution program. [PDF]

open access: yesCan J Public Health
Dos Santos B   +14 more
europepmc   +1 more source

[Pharmaceutical interventions in the new medicine service].

open access: yesFarm Comunitarios
Borja Ripoll S   +2 more
europepmc   +1 more source
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Opioids

Surgical Neurology, 2007
Opioids are the most effective and widely used drugs in the treatment of severe pain. They act through G protein-coupled receptors. Four families of endogenous ligands (opioid peptides) are known. The standard exogenous opioid analgesic is morphine. Opioid agonists can activate central and peripheral opioid receptors. Three classes of opioid receptors (
C, Zöllner, C, Stein
openaire   +4 more sources

Opioid Imaging

Neuroimaging Clinics of North America, 2006
Many breakthrough scientific discoveries have been made using opioid imaging. Developments include the application of ever higher resolution whole-brain positron emission tomography (PET) scanners, the availability of several radioligands, the combination of PET with advanced structural imaging, advances in modeling macroparameters of PET ligand ...
Hammers, Alexander   +1 more
openaire   +4 more sources

Opioid and non-opioid analgesics

Best Practice & Research Clinical Anaesthesiology, 2003
Opioids are the most potent analgesics. Toxicity results either from effects mediated by variation in affinity and intrinsic efficacy at specific opioid receptors or, rarely, from a direct toxic effect of the drugs. For some adverse effects, opioids exhibit a 'dual pharmacology' whereby these effects are usually observed only in pain-free individuals ...
Stephan A, Schug   +2 more
openaire   +2 more sources

Opioids

Neurologic Clinics, 1993
The major clinical uses for opioids are to control pain, suppress cough, and to treat diarrhea. These drugs, however, have the potential for abuse. It is postulated that the significant mood-altering effects of opioids combined with their pharmacology, in which tolerance and physical and psychological dependence occur, account for their abuse liability.
openaire   +2 more sources

Opioid receptor polymorphismsand opioid abuse

Pharmacogenomics, 2002
The sequencing of the human genome is only the first step. The next step is to determine the function of these genes and in particular, how alterations in specific genes lead to major human disorders. Many laboratories are now focusing on identifying and characterizing single nucleotide polymorphisms (SNPs), to determine which correlate in frequency ...
Nancy M, Lee, Andrew P, Smith
openaire   +2 more sources

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