Results 201 to 210 of about 26,064 (237)
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Opioid receptor polymorphismsand opioid abuse
Pharmacogenomics, 2002The sequencing of the human genome is only the first step. The next step is to determine the function of these genes and in particular, how alterations in specific genes lead to major human disorders. Many laboratories are now focusing on identifying and characterizing single nucleotide polymorphisms (SNPs), to determine which correlate in frequency ...
Nancy M, Lee, Andrew P, Smith
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, 2020
Nuestro objetivo es ejemplificar cómo el consumo de tóxicos y la comorbilidad con los trastornos mentales son factores de riesgo para el desarrollo de dependencia a opioides en pacientes tratados con analgésicos opioides.
Cándido Manuel García Sánchez +1 more
semanticscholar +1 more source
Nuestro objetivo es ejemplificar cómo el consumo de tóxicos y la comorbilidad con los trastornos mentales son factores de riesgo para el desarrollo de dependencia a opioides en pacientes tratados con analgésicos opioides.
Cándido Manuel García Sánchez +1 more
semanticscholar +1 more source
Opioid and anti‐opioid peptides
Fundamental & Clinical Pharmacology, 1995Summary— The numerous endogenous opioid peptides (β‐endorphin, enkephalins, dynorphins…) and the exogenous opioids (such as morphine) exert their effects through the activation of receptors belonging to four main types: μ, Δ, k and ε. Opioidergic neurones and opioid receptors are largely distributed centrally and peripherally. It is thus not surprising
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Acta Anaesthesiologica Scandinavica, 1997
Cancer pain generally responds in a predictable way to analgesic drugs and drug therapy is the mainstay of treatment. A small proportion of patients, of the order of 20%, have pain that does not respond well to conventional analgesic management. Because opioid analgesics are the most important part of this pharmacological approach, a terminology has ...
G W, Hanks, K, Forbes
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Cancer pain generally responds in a predictable way to analgesic drugs and drug therapy is the mainstay of treatment. A small proportion of patients, of the order of 20%, have pain that does not respond well to conventional analgesic management. Because opioid analgesics are the most important part of this pharmacological approach, a terminology has ...
G W, Hanks, K, Forbes
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Opioid Adjuvant Strategy: Improving Opioid Effectiveness
Future Medicinal Chemistry, 2016Opioid analgesics continue to be the mainstay of pharmacologic treatment of moderate to severe pain. Many patients, particularly those suffering from chronic pain, require chronic high-dose analgesic therapy. Achieving clinical efficacy and tolerability of such treatment regimens is hampered by the appearance of opioid-induced side effects such as ...
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Medicina Paliativa, 2018
Resumen Uno de los objetivos actuales de los cuidados paliativos es la intervencion en fases mas precoces de la enfermedad. Esto supone atender a un mayor numero de pacientes ambulatorios, con un pronostico de vida mas largo y potencialmente expuestos a ...
C. paliativos +3 more
semanticscholar +1 more source
Resumen Uno de los objetivos actuales de los cuidados paliativos es la intervencion en fases mas precoces de la enfermedad. Esto supone atender a un mayor numero de pacientes ambulatorios, con un pronostico de vida mas largo y potencialmente expuestos a ...
C. paliativos +3 more
semanticscholar +1 more source
Endocrine Practice, 2015
The use of prescription opioids has increased dramatically over the past 20 years. Opioids appear to affect multiple endocrine pathways leading to abnormal levels of different hormones such as testosterone, cortisol, and prolactin (PRL). In this article, we review the current data regarding opioid effects on the hypothalamus, pituitary, and bone ...
Susan P, Demarest +2 more
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The use of prescription opioids has increased dramatically over the past 20 years. Opioids appear to affect multiple endocrine pathways leading to abnormal levels of different hormones such as testosterone, cortisol, and prolactin (PRL). In this article, we review the current data regarding opioid effects on the hypothalamus, pituitary, and bone ...
Susan P, Demarest +2 more
openaire +2 more sources
Proceedings of the Society for Experimental Biology and Medicine, 2000
Opioid peptides have long been considered as neuropeptides or neurotransmitters. The more recent discovery of these same peptides in non-neuronal tissue suggests that the peptides may have autocrine, paracrine, or endocrine functions as well. The opioid peptides, enkephalins, dynorphins, and endorphins, have been found in isolated cardiac myocytes and ...
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Opioid peptides have long been considered as neuropeptides or neurotransmitters. The more recent discovery of these same peptides in non-neuronal tissue suggests that the peptides may have autocrine, paracrine, or endocrine functions as well. The opioid peptides, enkephalins, dynorphins, and endorphins, have been found in isolated cardiac myocytes and ...
openaire +2 more sources
Primary Care: Clinics in Office Practice, 2011
Opioid dependence is becoming a more common problem in the United States that gives rise to many negative health and social consequences for both individuals and society as a whole. Opioid dependence presents a challenging issue for physicians to identify and treat.
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Opioid dependence is becoming a more common problem in the United States that gives rise to many negative health and social consequences for both individuals and society as a whole. Opioid dependence presents a challenging issue for physicians to identify and treat.
openaire +2 more sources
Annual Review of Biochemistry, 2004
▪ Abstract Opioid receptors belong to the large superfamily of seven transmembrane-spanning (7TM) G protein-coupled receptors (GPCRs). As a class, GPCRs are of fundamental physiological importance mediating the actions of the majority of known neurotransmitters and hormones. Opioid receptors are particularly intriguing members of this receptor family.
Waldhoer, Maria +2 more
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▪ Abstract Opioid receptors belong to the large superfamily of seven transmembrane-spanning (7TM) G protein-coupled receptors (GPCRs). As a class, GPCRs are of fundamental physiological importance mediating the actions of the majority of known neurotransmitters and hormones. Opioid receptors are particularly intriguing members of this receptor family.
Waldhoer, Maria +2 more
openaire +3 more sources