Results 91 to 100 of about 41,014 (318)

Prediction of the Size Distributions of Methanol-Ethanol Clusters Detected in VUV Laser/Time-of-flight Mass Spectrometry [PDF]

open access: yes, 2009
The size distributions and geometries of vapor clusters equilibrated with methanol−ethanol (Me−Et) liquid mixtures were recently studied by vacuum ultraviolet (VUV) laser time-of-flight (TOF) mass spectrometry and density functional theory (DFT ...
Consta, Styliani   +4 more
core   +2 more sources

Metabolic Stress‐Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes‐Associated Microvascular Dysfunction

open access: yesAdvanced Science, EarlyView.
This study uncovers CHKA as a pivotal driver of vascular dysfunction in diabetic retinopathy and highlights its role in endothelial dysfunction through NAD⁺‐SIRT1‐Notch signaling. Single‐cell and functional analyses, combined with clinical and genetic validation, suggest CHKA as a promising therapeutic target for the prevention and treatment of ...
Ling Ren   +11 more
wiley   +1 more source

Surface‐Engineered Cenospheres Encapsulating Phase Change Materials for Functional Cementitious Composites

open access: yesAdvanced Science, EarlyView.
The global energy demand drives the need for advanced energy‐efficient building solutions. While current polymeric‐shell microencapsulated PCMs show promise for thermal energy storage, their use in cementitious materials is challenged by poor shell strength and interfacial bonding. This study develops novel cement‐compatible microencapsulated PCM using
Sahand Rahemipoor   +7 more
wiley   +1 more source

Further investigations on the relationship between the OPLS preprocessing and the NAS

open access: yesChemometrics and Intelligent Laboratory Systems, 2020
Abstract Orthogonal Projection to Latent Structures (OPLS) is a preprocessing method that was presented as an improvement of the PLS algorithm it was issued from. Nevertheless, according to the bibliography its added value is questionnable both for prediction and interpretation.
Boulet, Jean-Claude, Sabatier, Robert
openaire   +4 more sources

Dual‐Locking the SARS‐CoV‐2 Spike Trimer: An Amphipathic Molecular “Bolt” Stabilizes Conserved Druggable Interfaces for Coronavirus Inhibition

open access: yesAdvanced Science, EarlyView.
A new amphipathic molecule, S416 is discovered, that locks the SARS‐CoV‐2 spike protein in its closed state, blocking viral entry. S416 acts as a molecular bolt, binding six sites: three between adjacent RBDs and three connecting NTDs to RBDs. This dual‐locking mechanism stiffens the spike structure and reduces its flexibility.
Shiliang Li   +21 more
wiley   +1 more source

OPLS statistical model versus linear regression to assess sonographic predictors of stroke prognosis

open access: yesNeuropsychiatric Disease and Treatment, 2012
Kianoush Fathi Vajargah,1 Homayoun Sadeghi-Bazargani,2,3 Robab Mehdizadeh-Esfanjani,4 Daryoush Savadi-Oskouei,4 Mehdi Farhoudi41Department of Statistics, Islamic Azad University, Tehran, North Branch, 2Neuroscience Research Center, Department of ...
Fathi Vajargah K   +4 more
doaj  

Nanoparticle‐Mediated CXCL12–CXCR4 Inhibition Reprograms Macrophages and Suppresses Gastric Carcinoma

open access: yesAdvanced Science, EarlyView.
Molecular mechanism study of self‐assembled M2pep‐Cs NPs/Plerixafor nanoparticles in targeting MΦ reprogramming by regulating the CXCL12–CXCR4 signaling pathway to enhance immune recognition and clearance of GC (Created by BioRender). Abstract Gastric carcinoma (GC) remains a major global health challenge, requiring novel therapeutic approaches.
Qianqian Cao   +9 more
wiley   +1 more source

Targeted Intervention Strategies for Maternal–Offspring Transmission of Christensenellaceae in Pigs via a Deep Learning Model

open access: yesAdvanced Science, EarlyView.
This study deciphers maternal‐driven microbial transmission in pigs using a deep learning model (maternal–offspring microbial transmission model), identifying Christensenellaceae R‐7 group as a key transmitted taxon. Filtered galacto‐oligosaccharides‐targeted Christensenellaceae R‐7 group alters offspring microbial functions via maternal ...
Haibo Shen   +9 more
wiley   +1 more source

Energetics of endurance exercise in young horses determined by nuclear magnetic resonance metabolomics

open access: yesFrontiers in Physiology, 2015
Long-term endurance exercise severely affects metabolism in both human and animal athletes resulting in serious risk of metabolic disorders during or after competition.
Margaux Marie-Hélène, Olivia Luck   +8 more
doaj   +1 more source

Inhibition of Heat Shock Protein 90β by Catalpol: A Potential Therapeutic Approach for Alleviating Inflammation‐Induced Cartilage Injuries in Osteoarthritis

open access: yesAdvanced Science, EarlyView.
The schematic diagram delineates the chondroprotective effects of Ca‐bMSN in OA models. The upper portion of the diagram depicts the synthesis process of Ca‐bMSN. The lower section illustrates the post‐injection of Ca‐bMSN in joint cavity, catalpol released and subsequently mediates the reduction of oxidative stress, ECM catabolism, apoptosis, and ...
Zhenwei Zhou   +14 more
wiley   +1 more source

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