Results 81 to 90 of about 38,044 (266)

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

Detection of Mefenamic Acid in Hyperuricemia Herbal Medicine using UV-Vis Spectrophotometry and FTIR Spectroscopy Combined with Chemometrics

Journal of Food and Pharmaceutical Sciences
The adulteration of herbal medicines with synthetic drugs poses a serious risk to public health. Mefenamic acid, a non-steroidal anti-inflammatory drug (NSAID), is sometimes illicitly added to herbal products marketed for hyperuricemia to enhance their ...
Anggita Rosiana Putri, Nanda Kalima, Bachtiar Rifai Pratita Ihsan, Prisma Trida Hardaniani   +3 more
doaj   +1 more source

K-OPLS package: Kernel-based orthogonal projections to latent structures for prediction and interpretation in feature space

BMC Bioinformatics, 2008
Background Kernel-based classification and regression methods have been successfully applied to modelling a wide variety of biological data. The Kernel-based Orthogonal Projections to Latent Structures (K-OPLS) method offers unique properties ...
Holmes Elaine, Nicholson Jeremy K, Rantalainen Mattias, Bylesjö Max, Trygg Johan   +4 more
doaj   +1 more source

OPLS-DA (A and B) and XCMS (C and D) comparing the 24 h LPS-treated vs. 24 h non-treated cells.

, 2016
(A) The OPLS-DA scores plot and (B) the corresponding S-plot show the different clustering of treated and non-treated samples. The ellipse represents Hoteling’s T2 at 95% confidence interval and the model calculated PCs and gave R2X = 45.5%, R2Y = 99.7 ...
Paul A. Steenkamp (518435), Ntakadzeni E. Madala (3179010), Lizelle A. Piater (518436), Ian A. Dubery (518437), Msizi I. Mhlongo (3179013)   +4 more
core   +1 more source

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source

Water/Ionic Liquid Hybrid Electrolyte for High Cycling Stability and Low‐Temperature Adaptability in Aqueous Lithium‐Ion Battery

Advanced Science, EarlyView.
A dilute hybrid electrolyte containing only 10 mol% [EMIM][DEP] simultaneously reorganizes the water hydrogen‐bond network and creates an ionic‐liquid‐rich region at the anode. This coupled bulk and interfacial regulation suppresses freezing and hydrogen evolution, broadens the electrochemical stability window, and enables an aqueous LMO/LTP full cell ...
Jiwei He, Le Zhou, Mengmeng Cong, Keqiao Li, Donggyu Lee, Jiacheng Ji, Jinyu Deng, Zhigang Li, Baoling Huang   +8 more
wiley   +1 more source

Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions

JCI Insight, 2021
BACKGROUND The aberrant activation of the PI3K/mTOR signaling circuitry is one of the most frequently dysregulated signaling events in head and neck squamous cell carcinoma (HNSCC).
J. Silvio Gutkind, Alfredo A. Molinolo, Xingyu Wu, Zhiyong Wang, Daniela Nachmanson, Olivier Harismendy, Ludmil B. Alexandrov, Beverly R. Wuertz, Frank G. Ondrey, Denise Laronde, Leigha D. Rock, Miriam Rosin, Charles Coffey, Valerie D. Butler, Lisa Bengtson, Chiu-Hsieh Hsu, Julie E. Bauman, Stephen M. Hewitt, Ezra E.W. Cohen, H-H. Sherry Chow, Scott M. Lippman, Eva Szabo   +21 more
doaj   +1 more source

Preliminary study on the geographical origin of Chinese 'Cuiguan' pears using integrated stable isotope and multi-element analyses

Heliyon
Distinguish the geographical origin of the pear is important due to the increasingly valued brand protection and reducing the potential food safety risks.
Tingting Zeng, Tingting Fu, Yongchuan Huang, Wei Zhang, Jiuping Gong, Bingjing Ji, Xiaoxia Yang, Mingfeng Tang   +7 more
doaj   +1 more source

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

OPLS-DA- Quorum quenching activity.

, 2017
Score Scatter Plot of seven ethyl acetate extracts of strains 9, 46b, 87, 89.4, 102N, 184, 194. Active strain (black color) vs. non-active strain (gray color).
Luz A. Betancur (3772279), Sandra J. Naranjo-Gaybor (3772285), Diana M. Vinchira-Villarraga (3772267), Gillermo F. Padilla-Gonzalez (3772273), Luis A. Maldonado (1950733), Nubia C. Moreno-Sarmiento (3772276), Leonardo Castellanos (2039737), Mónica Puyana (3772288), Freddy A. Ramos (3772282), Alejandro Acosta-González (3772291), Zulma R. Suarez-Moreno (3772270)   +10 more
core   +1 more source