Results 91 to 100 of about 139,564 (313)

Efficacy, Safety, Pharmacokinetics, and Immunogenicity of ABBV‐154 in Adults With Glucocorticoid‐Dependent Polymyalgia Rheumatica: A Phase 2, Randomized, Double‐Blind, Placebo‐Controlled Trial

Arthritis &Rheumatology, EarlyView.
Objective An unmet need exists for glucocorticoid‐sparing treatments for patients with polymyalgia rheumatica (PMR). The antibody‐drug conjugate ABBV‐154 comprises adalimumab conjugated to a glucocorticoid receptor modulator. We evaluated ABBV‐154 versus placebo in patients with glucocorticoid‐dependent PMR.
Robert F. Spiera, Valerie Devauchelle‐Pensec, Claire E. Owen, Federico Díaz‐González, Tsutomu Takeuchi, Edit Drescher, Jaclyn Anderson, Dilek Arikan, Ronilda D'Cunha, Julie Parmentier, Denise T. Kruzikas, Weihan Zhao, Yang Yang, Karen Stellpflug, Frank Buttgereit   +14 more
wiley   +1 more source

CROR: Coding-Aware Opportunistic Routing in Multi-Channel Cognitive Radio Networks [PDF]

, 2015
Cognitive radio (CR) is a promising technology to improve spectrum utilization. However, spectrum availability is uncertain which mainly depends on primary user's (PU's) behaviors. This makes it more difficult for most existing CR routing protocols to achieve high throughput in multi-channel cognitive radio networks (CRNs). Inter-session network coding
arxiv   +1 more source

Long‐Term Safety and Efficacy of Mepolizumab in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Objective Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, relapsing, inflammatory disease. Management of EGPA predominantly relies on oral corticosteroids (OCS), which are associated with many adverse effects. The phase 3 MIRRA trial demonstrated efficacy and safety of mepolizumab, anti‐interleukin‐5 biologic, for EGPA.
Michael E. Wechsler, Jared Silver, Gerhard Wolff, Robert G. Price, Rejina Verghis, Peter F. Weller, Peter A. Merkel, Paneez Khoury, on behalf of the EGPA Mepolizumab Open‐Label Extension study group, Arnaud Bourdin, Pascal Chanez, Anoop Chauhan, Vincent Cottin, Gerald Gleich, Berhnard Hellmich, Tomonori Ishii, David Jayne, Jean‐Emmanuel Kahn, Peter Kern, Nader Khalidi, Ina Koetter, Carol Langford, Amy Markezich, Paul Monach, Shamsa Naveed, Peter Oelzner, Kenneth Pinna, Xavier Puechal, Emory H. Robinette, Florence Roufosse, Reinhard Voll, Andrew Schafer, Kaharu Sumino, Masami Taniguchi, Phillip Lieberman   +34 more
wiley   +1 more source

Secondary diseases in patients with HIV infection: 15-year follow-up

Терапевтический архив, 2004
Aim. To analyse the results of a 15-year study of opportunistic diseases in AIDS patients. Material and methods. The spectrum of opportunistic diseases were made in AIDS patients in respect to clinical, laboratory and autopsy data for the periods: 1987 ...
T N Ermak, A V Kravchenko, В М Gruzdev
doaj  

Blood, bone and brain nocardiosis infection in an HIV-infected man

JKKI (Jurnal Kedokteran dan Kesehatan Indonesia), 2016
Disseminated nocardiosis is a rare and complicated opportunistic bacterial infection with propensity of delay in establishing the correct diagnosis and high frequency for misdiagnosis and due to the non-specific clinical presentation and the inherent ...
Muhammad Yazli Yuhana
doaj   +1 more source

Opportunistic Wireless Relay Networks: Diversity-Multiplexing Tradeoff [PDF]

arXiv, 2011
Opportunistic analysis has traditionally relied on independence assumptions that break down in many interesting and useful network topologies. This paper develops techniques that expand opportunistic analysis to a broader class of networks, proposes new opportunistic methods for several network geometries, and analyzes them in the high-SNR regime.
arxiv  

Clinical factors associated with pneumocystis pneumonia despite its primary prophylaxis: When to stop prophylaxis?

Arthritis &Rheumatology, Accepted Article.
Objective Although previous studies show that primary prophylaxis against Pneumocystis jirovecii pneumonia (PJP) is effective in patients with rheumatic diseases receiving immunosuppressive treatment, there is limited evidence regarding the optimal timing for prophylaxis withdrawal.
Ju Yeon Kim, Se Rim Choi, Jin Kyun Park, Eun Young Lee, Eun Bong Lee, Jun Won Park   +5 more
wiley   +1 more source

Candidiasis Opportunistic Mycosis within Nigeria: A Review

UMYU Journal of Microbiology Research, 2019
Candidiasis as a disease is sometimes synonymous with woman folk and most human immunodeficiency virus (HIV) infected individuals. But the disease generally has no border, as it affects males, females, old, young and middle age persons.
Sule, H.,, Kumurya, A. S., Shema F. B.
doaj   +1 more source

Interpretable Network Propagation with Application to Expanding the Repertoire of Human Proteins that Interact with SARS-CoV-2 [PDF]

arXiv, 2020
Background: Network propagation has been widely used for nearly 20 years to predict gene functions and phenotypes. Despite the popularity of this approach, little attention has been paid to the question of provenance tracing in this context, e.g., determining how much any experimental observation in the input contributes to the score of every ...
arxiv  

Experiences in times of COVID‐19: Home‐life, social connections, and schooling for Aotearoa New Zealand children

British Educational Research Journal, EarlyView.
Abstract The impact of the COVID‐19 pandemic and associated lockdown measures on child and family functioning requires ongoing investigation to understand its far‐reaching effects. This study investigated the experiences of 10‐year‐old children (n = 2421) from the Growing Up in New Zealand longitudinal cohort during some of the strictest pandemic ...
Kane Meissel, Molly Grant, Elizabeth R. Peterson, Caroline Walker, Rebecca J. Evans, John Fenaughty, Carin Napier, Pat Bullen, Nandini Dubey, Susan M. B. Morton   +9 more
wiley   +1 more source