Results 41 to 50 of about 138,679 (267)

Pharmacokinetics, Efficacy, and Safety of Upadacitinib in Pediatric Patients With Polyarticular‐Course Juvenile Idiopathic Arthritis: An Interim Analysis of an Open‐Label, Phase 1 Trial

Arthritis Care &Research, EarlyView.
Objective This work aimed to evaluate the pharmacokinetics, efficacy, and safety of upadacitinib, an oral selective JAK inhibitor, in pediatric patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods In an open‐label, phase 1 study (SELECT‐YOUTH), enrolled patients, aged 2 to <18 years with pcJIA, received body weight–based ...
Hermine I. Brunner, Anna Shmagel, Gerd Horneff, Ivan Foeldvari, Jordi Antón, Athimalaipet V. Ramanan, Yuli Qian, Kristina Unnebrink, Shuai Hao, Heidi S. Camp, Nasser Khan, Wei Liu, Mohamed‐Eslam F. Mohamed   +12 more
wiley   +1 more source

Mucormycosis in a Diabetic Ketoacidosis Patient: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2016
Mucormycosis is the name given to several different diseases caused by fungi of the order mucorales. It is commonly seen in patients with decreased immunity like patients with chronic renal failure, organ transplantation, neutropenia and most commonly ...
Siddanagouda Biradar, Shivraj N Patil, Deepak Kadeli   +2 more
doaj   +1 more source

Metal–Organic Framework‐Based Antimicrobial Touch Surfaces to Prevent Cross‐Contamination

Advanced Materials, EarlyView.
A MOF‐based antimicrobial door handle cover is developed. It completely inhibits the cross‐contamination of Gram‐positive bacterial species (Staphylococcus aureus, and Enterococcus faecalis), Gram‐negative bacterial species (Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii), and fungi (Candida albicans). Abstract Infection diseases
Javier Fonseca, Mary Cano‐Sarabia, Pilar Cortés, Jordi Saldo, David Montpeyó, Julia Lorenzo, Montserrat Llagostera, Inhar Imaz, Daniel Maspoch   +8 more
wiley   +1 more source

NATURAL HISTORY OF HIV-INFECTION IN CHILDREN WITH THE ROUTE OF INFECTION

Детские инфекции (Москва), 2015
Natural history of HIV infection in 91 vertically HIV infected patients and in 101 parenterally HIV infected children were investigated. High relative incidence rates regardless of the route of HIV transmission have demonstrated HIV-related symptoms ...
V. B. Denisenko, E. N. Simovanyan
doaj   +1 more source

Stress Response of Aspergillus niger Spores to Copper Surfaces and the Implications for Antifungal Surface Functionalization

Advanced Materials Interfaces, EarlyView.
This study investigates the antifungal efficacy of ultrashort pulsed laser‐induced periodic surface structures (USP‐DLIP) on copper, brass, and steel surfaces. Using Aspergillus niger as a model, the research highlights a 99% reduction in spore viability on 9 µm structured copper surfaces due to enhanced copper ion release. Scanning electron microscopy
Stella Marie Timofeev, Katharina Siems, Daniel Wyn Müller, Aisha Saddiqa Ahmed, Alessa Schiele, Kristina Brix, Carolin Luisa Krämer, Franca Arndt, Ralf Kautenburger, Frank Mücklich, Stefan Leuko   +10 more
wiley   +1 more source

Gut Microbiota Modulation by Inulin Improves Metabolism and Ovarian Function in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
This work proposes a novel strategy targeting gut microbiota for managing polycystic ovary syndrome (PCOS). Inulin, a gut microbiota modulator, notably boosts the growth of short‐chain fatty acids (SCFAs)‐producers, represented by Bifidobacterium, thereby improving glucolipid metabolism and ovarian function of PCOS through suppressing the inflammatory ...
Lulu Geng, Xin Yang, Jiani Sun, Ximing Ran, Dan Zhou, Mingming Ye, Li Wen, Ruirui Wang, Miaoxin Chen   +8 more
wiley   +1 more source

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, EarlyView.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source

Charting the landscape of the environmental exposome

iMeta, Volume 1, Issue 4, December 2022., 2022
We describe the biological and chemical components of the environmental exposomes in three major environmental matrices that are highly relevant to human and social‐economical health—air, soil, and water. We discuss how different exposome components can interact with each other. Finally, we propose a list of outstanding challenges to be tackled to push
Xin Wei, Zinuo Huang, Liuyiqi Jiang, Yueer Li, Xinyue Zhang, Yuxin Leng, Chao Jiang   +6 more
wiley   +1 more source

Hydrogel‐Based Smart Materials for Wound Healing and Sensing

Aggregate, EarlyView.
The graphical abstract illustrates the role of hydrogel‐based flexible materials in advancing biomedical applications, including wound healing, point‐of‐care diagnostics, smart patches, and wearable devices. Hydrogels are particularly promising in modern wound care due to their high‐water content, flexibility, and biocompatibility.
Thi Kim Ngan Duong, Thi Thuy Truong, Thi Nhat Linh Phan, Thi Xuan Nguyen, Vu Hoang Minh Doan, Truong Tien Vo, Jaeyeop Choi, Umapada Pal, Prodyut Dhar, Byeongil Lee, Junghwan Oh, Sudip Mondal   +11 more
wiley   +1 more source

Gut microbiota‐stem cell niche crosstalk: A new territory for maintaining intestinal homeostasis

iMeta, Volume 1, Issue 4, December 2022., 2022
Intestinal stem cells (ISCs) are protected by their niche and are regulated by Wnt, bone morphogenetic protein, and Notch. ISCs and their relationship with intestinal microbiota provide a feasible pathway to alleviate intestinal diseases. Diverse bacteria‐related postbiotics regulate ISCs and maintain their homeostasis.
Ning Ma, Xiyue Chen, Lee J. Johnston, Xi Ma   +3 more
wiley   +1 more source