Results 61 to 70 of about 1,065,107 (264)
Evaluation of testing methods for tracking CIPP liners’ life-cycle performance
Cogent Engineering, 2018 Despite the significant investments made in the use of cured-in-place pipe (CIPP) rehabilitation technologies, quality assurance (QA) and quality control (QC) practices can vary widely among municipalities, and CIPP liner evaluations are mostly ...
S. Alam +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Journal of ICTTraditional educational assessment systems in Malaysia face persistent issues such as data security vulnerabilities, lack of transparency, and centralised control, which collectively undermine trust, reliability, and operational efficiency.
Joharri Shuhaimi +5 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Social Media + SocietyTo explain the participatory effects of news exposure, communication scholars have long relied upon the “virtuous circle” framework of media use and civic participation.
Sangwon Lee, Sebastián Valenzuela
doaj +1 more source
The American Journal of Nursing, 1922 Two classes have entered the training school since our organization. As a result of the experiment of student government in our clswss, the younger classes have adopted it and the whole school is now under one constitution and by-laws. The authority is vested in the Student Council, which includes a member from each class, the president and the ...
openaire +2 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source