Results 101 to 110 of about 6,863,082 (290)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
بهداشت و ایمنی کار, 2020 Introduction: Patients’ safety culture indicates the extent to which the staffs prioritize the safety of patients. In medical centers, it is very important to pay attention to the patients’safety. Hence, the patients’safety culture should be examined and
Sima Parizadeh, Kiomars Beshlideh
doaj
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Din ve Yabancılaşma: İmkânlar, Fırsatlar ve Tehlikeler
İlahiyat Akademi, 2016 Çok genel bir anlam içeren yabancılaşma kavramına değişik disiplinlerden farklı anlamlar yüklense de kavrama yüklenen anlamların yoğunlaştığı alan bireysel temelde olup, yabancılaşma bireyde meydana gelmektedir.
Faruk Karaca
doaj
Connecticut Postsecondary Pathways for Opportunity Youth [PDF]
, 2015 Pathways to Postsecondary Opportunities are the range of options created across education institutions, training providers, and community-based organizations so that each and every young person can access the necessary and personally relevant ...
core
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Nauka ta progres transportu, 2008 Presently computers are more utilized in the mode of batch processing or solution of separate jobs, which are loaded from the stand of operator. In spite of the fact that at present the advantages of the real-time systems and dialog modes of their ...
S. O. Yakovlev, S. I. Khryshcheniuk
doaj
FEBS Open Bio, EarlyView.We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima +4 more
wiley +1 more source