Results 51 to 60 of about 1,305,290 (246)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Market Opportunity and Policy Support for Chinese Old Aging Industry: An Application of Text Mining

SHS Web of Conferences, 2017
Text mining has become a vital method of natural and social science research. A policy documents text mining framework with three phases has been introduced.
Li Chenguang
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A Window Into Park Life: Findings From a Resident Survey of Nine Mobile Home Park Communities in Vermont

Journal of Rural and Community Development, 2011
Affordable housing is a critical issue facing many rural communities. Mobile home parks are a form of affordable housing prevalent in rural areas that is being lost as parks close across the United States and few new parks are developed. Limited research
Daniel Baker, Kelly Hamshaw, Corey Beach
doaj  

Inequities in food access during the COVID-19 pandemic: A multilevel, mixed methods pilot study

BMC Public Health
Background Innovative data integration may serve to inform rapid, local responses to community needs. We conducted a mixed methods pilot study among communities of color or low-income in the San Francisco Bay Area amid the COVID-19 pandemic to assess a ...
Megha R. Aepala, Alice Guan, Tessa Cruz, Jamaica Sowell, Brenda Mathias, Katherine Lin, Analena Hope Hassberg, Salma Shariff-Marco, Mindy C. DeRouen, Antwi Akom   +9 more
doaj   +1 more source

Budget impact and cost-utility analysis of prophylactic emicizumab versus on-demand bypassing agents for adolescent severe haemophilia A patients with inhibitors in India

Heliyon
Introduction: Severe Haemophilia A patients with inhibitors are currently being treated with bypassing agents like activated prothrombin complex concentrates (aPCC) and recombinant factor VIIa.
Yuvaraj Krishnamoorthy, Dhanajayan Govindan, Narasimhapriyan Kannan, Marie Gilbert Majella, Vishnu Shankar Hariharan, Vivek Valliappan   +5 more
doaj   +1 more source

Have a Look Around: The Effect of a ‘Push’ Activity on Future SAS Use

Studies in Self-Access Learning Journal, 2020
Although mandatory regular use of self-access centres is surprisingly common, this goes against the purpose of them to foster autonomous learning. However, some students never consider using such resources without being pushed to do so.
André Parsons, Stuart Warrington
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source