Results 71 to 80 of about 4,672,355 (357)
, 1985 A quarterly newsletter describing the events at Wil Lou Gray Opportunity ...
Wil Lou Gray Opportunity School
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Opportunity Versus Necessity Entrepreneurship: Two Components of Business Creation
Social Science Research Network, 2018 A common and seemingly paradoxical finding in the entrepreneurship literature is that business creation increases in recessions. We investigate this countercyclical pattern by separating business creation into two components: “opportunity” and “necessity”
R. Fairlie, Frank M. Fossen
semanticscholar +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Negotiating the swamp: the opportunity and challenge of reflexivity in research practice
, 2002 How should researchers reflexively evaluate ways in which intersubjective elements transform their research? The process of engaging in reflexivity is full of muddy ambiguity and multiple trails as researchers negotiate the swamp of interminable ...
L. Finlay
semanticscholar +1 more source
Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge
Environmental Health Perspectives, 2017 Background: A rich body of literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), and there is strong support for an important role of ultrafine (nanosized) particles.
V. Stone +18 more
semanticscholar +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Market Opportunity and Policy Support for Chinese Old Aging Industry: An Application of Text Mining
SHS Web of Conferences, 2017 Text mining has become a vital method of natural and social science research. A policy documents text mining framework with three phases has been introduced.
Li Chenguang
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Low Income Families and Opportunity [PDF]
, 2006 Despite considerable progress over last several decades, low-income families continue to face many barriers to opportunity. In 2004 the number and rate of people in poverty increased for the fourth consecutive year. This is just one sign that opportunity
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source