Results 61 to 70 of about 4,579,259 (328)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

The Target Opportunity Costs of Successful Nudges

, 2020
Nudges are increasingly popular, in large part due to the typically low costs required to implement them. Yet most often the main cost of nudging is due not to their implementation, but rather to the opportunity costs of its successful change of the ...
Avishalom Tor, Tor, Avishalom
core   +1 more source

A micro-level study of the economic losses of traffic congestion delays in Srinagar city of Kashmir valley

Discover Cities
Traffic congestion is a common problem in developing countries, especially in major cities that cost huge sums of money and labour hours, and all signs point to it worsening in the future, endangering the quality of urban life.
Farzana Ahad, Huma Rashid, Shamim Ahmad Shah, Mohammad Shafi Bhat, Peer Jeelani   +4 more
doaj   +1 more source

The Uncertainty Trade-off: Reexamining Opportunity Costs and War

International Studies Quarterly, 2019
Conventional wisdom about economic interdependence and international conflict predicts that increasing opportunity costs make war less likely, but some wars occur after costs grow. Why?
William Spaniel, Iris Malone
semanticscholar   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The Opportunity Cost of COVID-19 Deaths in the USA

Economies
The U.S. is currently the country with the highest number of COVID-19 deaths. By the second week of October 2021, over 700,000 people in the U.S. had died after contracting the virus. When estimating the cost and benefit of a COVID-19 prevention measure,
Tuyen Pham, Anirudh V. S. Ruhil, G. Jason Jolley   +2 more
doaj   +1 more source

A Nested Land Uses–Landscapes–Livelihoods Approach to Assess the Real Costs of Land-Use Transitions: Insights from Southeast Asia

Land, 2019
Reducing emissions from deforestation and forest degradation (REDD+) is viewed as an effective way to mitigate climate change by compensating stewards of forested areas for minimizing forestland conversion and protecting forest services.
Guillaume Lestrelin, Jean-Christophe Castella, Qiaohong Li, Thoumthone Vongvisouk, Nguyen Dinh Tien, and Ole Mertz   +5 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Nonmarket Economic Valuation and "The Economist’s Fallacy"

Journal of MultiDisciplinary Evaluation, 2009
It is important that noneconomists understand and consider three key points regarding the use of economic cost-benefit analysis. First, economists undertaking applied cost-benefit analyses use expected values by necessity in forward-looking models ...
Murray A Rudd
doaj   +1 more source