Results 191 to 200 of about 280,340 (213)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Selective Opposition based Grey Wolf Optimization
Expert Systems With Applications, 2020 The use of metaheuristics is widespread for optimization in both scientific and industrial problems due to several reasons, including flexibility, simplicity, and robustness.
Ram Sarkar +2 more
exaly +2 more sources
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Opposition in times of crisis: COVID-19 in parliamentary debates
West European Politics, 2021Or Tuttnauer +2 more
exaly
Opposition based learning: A literature review
Swarm and Evolutionary Computation, 2018Kalyanmoy Deb +2 more
exaly
How Populists Wage Opposition: Parliamentary Opposition Behaviour and Populism in Netherlands
Political Studies, 2019Simon P. Otjes, Tom Louwerse
exaly