Results 61 to 70 of about 550,063 (331)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

PMT: Opposition-Based Learning Technique for Enhancing Meta-Heuristic Performance

IEEE Access, 2019
Meta-heuristic algorithms have shown promising performance in solving sophisticated real-world optimization problems. Nevertheless, many meta-heuristic algorithms are still suffering from a low convergence rate because of the poor balance between ...
Hammoudeh S. Alamri, Kamal Z. Zamli
doaj   +1 more source

Neoliberalism and the Contradictions of Freedom: Ideology, Subjectivity, and Critical Pedagogy [PDF]

, 2015
The idea of freedom is a central figure in the ideology of neoliberalism. In the contemporary context, neoliberals argue that rolling back regulations and the marketization of social life create more choices and thus more freedom.
De Lissovoy, Noah
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Discourses of ‘equivalence’ in HE and notions of student engagement : resisting the neoliberal university [PDF]

, 2014
Copyright © 2014 Nadia Edmond and Jon Berry. This is an open access journal article distributed under the Creative Commons Attribution License, which permits the unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Berry, Jon, Edmond, Nadia
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Contemporary paradigms on actor training methodologies : articulated knowledge at The Bridge of Winds' group [PDF]

, 2015
The Bridge of Winds is an ensemble of actors and theatre artists from South America, Europe and Asia, that has since 1989 researched the actor's physical and vocal training. Guided by Iben Nagel Rasmussen, the Odin Teatret actress, the group explores the
Parente La Selva, Adriana, Turosik, Marek   +1 more
core  

The first automated negotiating agents competition (ANAC 2010)

, 2011
Motivated by the challenges of bilateral negotiations between people and automated agents we organized the first automated negotiating agents competition (ANAC 2010).
Baarslag, Tim, Hindriks, Koen, Jonker, Catholijn M., Kraus, Sarit, Lin, Raz   +4 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Meeting the National Interest through Asia Literacy - An Overview of the Major Stages and Debates [PDF]

, 2003
This paper traces the evolution of ideas on the question of how Australians might become Asia-literate. It examines the main phases in those government and non-government reports on Asian languages and studies that called for a national strategy for Asia
Henderson, Deborah
core   +3 more sources