Results 71 to 80 of about 550,063 (331)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Hyper-parameter tuning for support vector machine using an improved cat swarm optimization algorithm

Journal of Nigerian Society of Physical Sciences, 2023
Support vector machine (SVM) is a supervised machine learning algorithm for classification and regression problems. SVM performs better when combined with other classifiers or optimized with an optimization algorithm.
Silifat Adaramaja Abdulraheem, Salisu Aliyu, Fatima Binta Abdullahi   +2 more
doaj   +1 more source

A simple hybrid algorithm for improving team sport AI [PDF]

, 2015
In the very popular genre of team sports games defeating the opposing AI is the main focus of the gameplay experience. However the overall quality of these games is significantly damaged because, in a lot of cases, the opposition is prone to mistakes or ...
Edwards, D, King, David J.
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Modified Bat Algorithm Based on Lévy Flight and Opposition Based Learning [PDF]

Scientific Programming, 2016
Bat Algorithm (BA) is a swarm intelligence algorithm which has been intensively applied to solve academic and real life optimization problems. However, due to the lack of good balance between exploration and exploitation, BA sometimes fails at finding global optimum and is easily trapped into local optima. In order to overcome the premature problem and
Xian Shan, Kang Liu, Pei-Liang Sun
openaire   +1 more source

Judith Butler's Critique of Binary Gender Opposition in Gender Trouble: A Task-Based Lesson Sequence [PDF]

, 2018
This chapter presents a task-based lesson sequence based on Judith Butler's Gender Trouble. Gender Trouble is a great piece of philosophical literature.
Euler, Sasha S.
core  

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Research on opposition-based enhanced fireworks algorithm optimization for mine ventilation network

Gong-kuang zidonghua, 2019
A non-linear unrestraint optimization model of mine ventilation network was established which took the minimum total energy consumption of mine ventilation network as optimization objective.
WU Xinzhong, HU Jianhao, WEI Lianjiang, QIAN Xiaoyu, REN Zihui, ZHANG Zhichao   +5 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Collaborative Optimization of Air Compressor Units Based on MSI-BWO Algorithm

IEEE Access
To improve the operational efficiency of compressor units and reduce waste, a Multi-Strategy Improved Beluga Whale Optimization (MSI-BWO) algorithm is proposed for the collaborative combination optimization of compressor units in an air compressor plant.
Lei Chen, Jiaxin Hou, Xiaolong Zheng, Tao Zhang, Chunhua Hu   +4 more
doaj   +1 more source