Results 71 to 80 of about 23,776 (285)

Optogenetic Gene Therapy for the Degenerate Retina: Recent Advances

Frontiers in Neuroscience, 2020
The degeneration of light-detecting rod and cone photoreceptors in the human retina leads to severe visual impairment and ultimately legal blindness in millions of people worldwide.
Michelle E. McClements, Federica Staurenghi, Robert E. MacLaren, Robert E. MacLaren, Jasmina Cehajic-Kapetanovic, Jasmina Cehajic-Kapetanovic   +5 more
doaj   +1 more source

Deciphering Molecular Mechanisms and Intervening in Physiological and Pathophysiological Processes of Ca²⁺ Signaling Mechanisms Using Optogenetic Tools

Cells, 2021
Calcium ion channels are involved in numerous biological functions such as lymphocyte activation, muscle contraction, neurotransmission, excitation, hormone secretion, gene expression, cell migration, memory, and aging.
Lena Maltan, Hadil Najjar, Adéla Tiffner, Isabella Derler   +3 more
doaj   +1 more source

Expression of Non-visual Opsins Opn3 and Opn5 in the Developing Inner Retinal Cells of Birds. Light-Responses in Müller Glial Cells

Frontiers in Cellular Neuroscience, 2019
The avian retina is composed of different types of photoreceptors responsible for image and non-image forming tasks: the visual photoreceptor cells (cones and rods), the melanopsin-expressing intrinsically photoresponsive retinal ganglion cells (ipRGCs ...
M. N. Ríos, N. A. Marchese, M. Guido
semanticscholar   +1 more source

Upconversion‐Based Remote Deep Brain Modulation for Therapeutic Dissection of Parkinson's Disease

Advanced Therapeutics, EarlyView.
An upconversion‐based wireless optogenetic strategy enables an all‐optical deep brain modulation solution for treating Parkinson's disease in rodent animals without using electronics or any tethered cables, providing experimental evidence supporting a therapeutic mechanism of STN‐DBS by disruption of anterograde signal transmission along the indirect ...
Wenchong Zhang, Xudong Lin, Kai Xie, Zixun Wang, Tianying Sun, Zhen Xu, Haibing Yue, Xi Chen, Qinghai Liao, Ming Liu, Wing Ho Yung, Jufang He, Feng Wang, Peng Shi   +13 more
wiley   +1 more source

The Circadian Clock Gene Bmal1 Controls Thyroid Hormone-Mediated Spectral Identity and Cone Photoreceptor Function

Cell Reports, 2017
Circadian clocks regulate various aspects of photoreceptor physiology, but their contribution to photoreceptor development and function is unclear. Cone photoreceptors are critical for color vision.
Onkar B. Sawant, Amanda M. Horton, Olivia F. Zucaro, Ricky Chan, Vera L. Bonilha, Ivy S. Samuels, Sujata Rao   +6 more
doaj   +1 more source

Penaeid shrimp genome provides insights into benthic adaptation and frequent molting [PDF]

, 2019
Crustacea, the subphylum of Arthropoda which dominates the aquatic environment, is of major importance in ecology and fisheries. Here we report the genome sequence of the Pacific white shrimp Litopenaeus vannamei, covering similar to 1.66 Gb (scaffold ...
Alcivar-Warren, Acacia, Chen, Jack, Chu, Ka Hou, Gao, Yi, Jin, Songjun, Kong, Jie, Li, Fuhua, Li, Shihao, Lin, Wenchao, Liu, Bin, Liu, Chengzhang, Liu, Zhanjiang, Lv, Xinjia, Ma, Ka Yan, Ruan, Jue, Sagi, Amir, Sorgeloos, Patrick, Sun, Yamin, Wang, Lei, Wang, Long, Wang, Quanchao, Wang, Xiaobo, Xiang, Jianhai, Xu, Peng, Yu, Kuijie, Yu, Yang, Yuan, Jianbo, Zhang, Chengsong, Zhang, Hongbin, Zhang, Jiquan, Zhang, Xiaojun, Zhang, Xiaoxi, Zhu, Xueli   +32 more
core   +3 more sources

Nanotherapy for Neural Retinal Regeneration

Advanced Science, EarlyView.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen‐Bin Wei   +11 more
wiley   +1 more source

Post‐Translational Modifications in Cilia and Ciliopathies

Advanced Science, EarlyView.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source

From Embryo to Adult Life: Differential Expression of Visual Opsins in the Flatfish Solea senegalensis Under Different Light Spectra and Photoperiods

Frontiers in Marine Science, 2022
Visual photoreceptors in fish are usually adjusted to the light environment to ensure the highest efficiency and best adaptation. In the Senegalese sole, metamorphosis determines migration from pelagic to benthic habitats, with marked differences in both
Sara Frau, José A. Paullada-Salmerón, José A. Paullada-Salmerón, José A. Paullada-Salmerón, Isabella Paradiso, Mairi E. Cowan, Mairi E. Cowan, Águeda J. Martín-Robles, Águeda J. Martín-Robles, Águeda J. Martín-Robles, José A. Muñoz-Cueto, José A. Muñoz-Cueto, José A. Muñoz-Cueto   +12 more
doaj   +1 more source

Chromosome‐Level Genome Assembly of the Leafcutter Bee Megachile rotundata Reveals Its Ecological Adaptation and Pollination Biology

Advanced Science, EarlyView.
The genome of Megachile rotundata, an extensively managed solitary pollination bee species, has been sequenced, covering 280.68 Mb and predicting 10 701 genes. The study reveals significant expansions of the Toll gene family and their abundant expression in diapause prepupae, highlighting enhanced immune responses during diapause. This genome serves as
Rangjun Shi, Pan Duan, Mengmeng Zhu, Rong Zhang, Zihua Zhao, Xin Nie, Hanhou He, Li Hou, Xianhui Wang   +8 more
wiley   +1 more source