Results 51 to 60 of about 2,091 (202)

Ocular changes as potential biomarkers for early diagnosis of Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 8, August 2025.
Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. AD diagnosis often involves a thorough assessment, including clinical evaluation, cognitive testing, medical history examination, genetic testing, and biomarker analysis. Currently, the invasive nature and high costs of biomarker testing,
Purna Chandra Poudel, Shaun M. Frost, Shaun Eslick, Hamid R. Sohrabi, Kevin Taddei, Eugene Hone, Ralph N Martins   +6 more
wiley   +1 more source

Strategies for improving early detection and diagnosis of neovascular age-related macular degeneration [PDF]

, 2015
Treatment of the neovascular form of age-related macular degeneration (AMD) has been revolutionized by the introduction of such agents as ranibizumab, bevacizumab, and aflibercept.
Agrawal, Rupesh, De Salvo, Gabriella, Goverdhan, Srini, Keane, Pearse A., Sim, Dawn A., Tufail, Adnan   +5 more
core   +2 more sources

Expanding the Interface: Overlooked Dermatologic Disorders With Ocular Involvement

JEADV Clinical Practice, Volume 4, Issue 5, Page 1239-1243, December 2025.
A George
wiley   +1 more source

Sophisticated Ensemble Deep Learning Approaches for Multilabel Retinal Disease Classification in Medical Imaging

CAAI Transactions on Intelligence Technology, Volume 10, Issue 4, Page 1159-1173, August 2025.
ABSTRACT This paper introduces a novel ensemble Deep learning (DL)‐based Multi‐Label Retinal Disease Classification (MLRDC) system, known for its high accuracy and efficiency. Utilising a stacking ensemble approach, and integrating DenseNet201, EfficientNetB4, EfficientNetB3 and EfficientNetV2S models, exceptional performance in retinal disease ...
Asghar Amir, Tariqullah Jan, Mohammad Haseeb Zafar, Shadan Khan Khattak   +3 more
wiley   +1 more source

The role and therapeutic potential of melatonin in age-related ocular diseases [PDF]

, 2017
The eye is continuously exposed to solar UV radiation and pollutants, making it prone to oxidative attacks. In fact, oxidative damage is a major cause of age-related ocular diseases including cataract, glaucoma, age-related macular degeneration and ...
Colligris, Basilio, Crooke, Almudena, Huete Toral, Fernando, Pintor, Jesús   +3 more
core   +2 more sources

Non-syndromic retinitis pigmentosa [PDF]

, 2018
Retinitis pigmentosa (RP) encompasses a group of inherited retinal dystrophies characterized by the primary degeneration of rod and cone photoreceptors. RP is a leading cause of visual disability, with a worldwide prevalence of 1:4000.
Verbakel, S.K. (Sanne K.), van Huet, R.A.C. (Ramon A. C.), Boon, C.J.F. (Camiel), Hollander, A.I. (Anneke), Collin, R.W.J. (Rob), Klaver, C.C.W. (Caroline), Hoyng, C.B. (Carel), Roepman, R. (Ronald), Klevering, B.J. (Jeroen)   +8 more
core   +2 more sources

Signs of Intracranial Hypertension in Chronic Inflammatory Polyradiculoneuropathies—A Cross Sectional Cohort Study

European Journal of Neurology, Volume 32, Issue 7, July 2025.
This prospective cross‐sectional study screened 27 patients with inflammatory polyradiculoneuropathy (IPN) for signs of intracranial hypertension (IH) using multimodal ophthalmological assessments (fundoscopy, perimetry, OCT, ultrasonography). Signs of IH were identified in 37% of patients.
Stefan Macher, Nik Krajnc, Jakob Rath, Wolfgang Marik, Martin Michl, Christoph Stapf, Nina Mueller, Klaus Novak, Christian Woeber, Sina Zaic, Gudrun Zulehner, Fritz Zimprich, Berthold Pemp, Gabriel Bsteh   +13 more
wiley   +1 more source

Automated Glaucoma Detection Using Hybrid Feature Extraction in Retinal Fundus Images [PDF]

, 2012
Glaucoma is one of the most common causes of blindness. Robust mass screening may help to extend the symptom-free life for affected patients. To realize mass screening requires a cost-effective glaucoma detection method which integrates well with digital
Acharya U. R., Gonzalez R. C., Iester M., Kolar R., M MUTHU RAMA KRISHNAN, Nagarajan R., OLIVER FAUST, Swindale N. V., Uchida H.   +8 more
core   +1 more source

Optic Disc Pallor in Parkinson's Disease: A UK Biobank Study

Movement Disorders, Volume 40, Issue 6, Page 1123-1133, June 2025.
Abstract Background Recent studies have suggested that retinal changes measured with optical coherence tomography are detectable in early Parkinson's disease (PD), highlighting the potential of ophthalmic biomarkers for diagnosis and monitoring. Objective We set out to investigate the relationship between optic disc pallor measured in fundoscopy images
Samuel Gibbon, David P. Breen, Thomas J. MacGillivray, UK Biobank Eye & Vision Consortium   +3 more
wiley   +1 more source

Normative prospective data on automatically quantified retinal morphology correlated to retinal function in healthy ageing eyes by two microperimetry devices

Acta Ophthalmologica, Volume 103, Issue 4, Page 423-431, June 2025.
Abstract Purpose The relationship between retinal morphology, as assessed by optical coherence tomography (OCT), and retinal function in microperimetry (MP) has not been well studied, despite its increasing importance as an essential functional endpoint for clinical trials and emerging therapies in retinal diseases.
Klaudia Birner, Leonard M. Coulibaly, Johannes Schrittwieser, Irene Steiner, Hamza Mohamed, Simon Schürer‐Waldheim, Markus Gumpinger, Hrvoje Bogunovic, Ursula Schmidt‐Erfurth, Gregor S. Reiter   +9 more
wiley   +1 more source