Results 81 to 90 of about 94,408 (300)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

On discontinuous optical flow

Comput. Artif. Intell., 2000
This paper deals with an analysis of image motion in frequency space with respect to motion discontinuities and surface translucence. The frequency structure of motion discontinuities due to occlusion is derived under models of constant and linear optical flow. Authors demonstrate its various geometrical properties.
Beauchemin, S. S., Barron, J. L.
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Shape of a Vehicle Windshield Affects Reaction Time and Brain Activity During a Target Detection Task

Frontiers in Human Neuroscience, 2020
Background: Achieving clear visibility through a windshield is one of the crucial factors in manufacturing a safe and comfortable vehicle. The optic flow (OF) through the windshield has been reported to divert attention and could impair visibility ...
Takafumi Sasaoka, Maro G. Machizawa, Yoshihisa Okamoto, Koji Iwase, Toshihiro Yoshida, Nanae Michida, Atsuhide Kishi, Masaki Chiba, Kazuo Nishikawa, Shigeto Yamawaki, Takahide Nouzawa   +10 more
doaj   +1 more source

Amodal Optical Flow

2024 IEEE International Conference on Robotics and Automation (ICRA)
Optical flow estimation is very challenging in situations with transparent or occluded objects. In this work, we address these challenges at the task level by introducing Amodal Optical Flow, which integrates optical flow with amodal perception. Instead of only representing the visible regions, we define amodal optical flow as a multi-layered pixel ...
Luz, Maximilian, Mohan, Rohit, Sekkat, Ahmed Rida, Sawade, Oliver, Matthes, Elmar, Brox, Thomas, Valada, Abhinav   +6 more
openaire   +3 more sources

Representation of behaviourally relevant information by blowfly motion-sensitive visual interneurons requires precise compensatory head movements

, 2006
Flying blowflies shift their gaze by saccadic turns of body and head, keeping their gaze basically fixed between saccades. For the head, this results in almost pure translational optic flow between saccades, enabling visual interneurons in the fly motion
Hateren, J. H. van, Egelhaaf, M., Egelhaaf, Martin ; https://orcid.org/, Egelhaaf, M.,, Hateren, J.H. van, Hateren, J.H. van,, Kern, Roland, Kern, R.,, Kern, R.   +8 more
core   +2 more sources

Optic flow-based robotics [PDF]

, 2016
International audienceFlying insects and birds are able to fly smartly in an unpredictable environment. Many animals have been found to rely mainly on optic flow.
Julien Serres, Franck Ruffier, Serres, Julien, Ruffier, Franck   +3 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Function of a Fly Motion-Sensitive Neuron Matches Eye Movements during Free Flight

, 2005
Sensing is often implicitly assumed to be the passive acquisition of information. However, part of the sensory information is generated actively when animals move.
Roland Kern (108), J. H van Hateren (275094), Kern Roland, Lindemann Jens Peter, Egelhaaf Martin, Roland Kern, Jens Peter Lindemann, Christian Michaelis (110), Hateren, J.H. van, Hateren, J.H. van,, Martin Egelhaaf (112), Michaelis, Christian, Michaelis, Christian,, J. H. Van Hateren, Michaelis, C, Egelhaaf, Martin, van Hateren, JH, Kern, Roland,, Kern, Roland, Egelhaaf, Martin,, Jens Peter Lindemann (111), Michaelis Christian, Lindemann, Jens Peter ; https://orcid.org/, Lindemann, Jens Peter,, Lindemann, Jens Peter, Egelhaaf, Martin ; https://orcid.org/, Martin Egelhaaf, Kern, Roland ; https://orcid.org/, Christian Michaelis, J H van Hateren, van Hateren J. H   +30 more
core   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source