Results 51 to 60 of about 81,329 (311)

Longitudinal Study of Salivary Biomarkers in the Definition of Clinico‐Molecular Progression of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
Longitudinal changes in salivary biomarkers in Parkinson’s disease (PD) from early (T0) to 4‐year follow‐up (T1), quantified by ELISA: oligomeric and total α‐synuclein, total and phosphorylated tau, MAP1LC3B (autophagy), and TNFa (inflammation). Blue arrows indicate direction of change at T1 vs T0 (up = increase; down = decrease).
Maria Ilenia De Bartolo, Daniele Belvisi, Matteo Costanzo, Claudia Caturano, Francesco Emanuele Bellomi, Carolina Cutrona, Flavia Aiello, Giorgio Leodori, Massimo Marano, Romina Mancinelli, Antonella Conte, Giovanni Fabbrini, Alfredo Berardelli, Giorgio Vivacqua   +13 more
wiley   +1 more source

Characteristics of Cerebral Palsy in the Midwestern US

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebral palsy (CP) is the most common lifelong motor disability worldwide. Yet, data is limited on how CP manifests in the US. Our objective was to characterize and determine factors affecting functional outcomes in a large population of young people with CP in the Midwestern US.
Susie Kim, Kelsey Steffen, Lauren Gottschalk‐Henneberry, Jennifer Miros, Amy Robichaux‐Viehoever, Karen Taca, Bhooma R. Aravamuthan   +6 more
wiley   +1 more source

Clinical Applications of the Photopic Negative Response to Optic Nerve and Retinal Diseases

Journal of Ophthalmology, 2012
The photopic negative response (PhNR) in response to a brief flash is a negative-going wave following the b-wave of the cone electroretinogram (ERG) that is driven by retinal ganglion cells (RGCs).
Shigeki Machida
doaj   +1 more source

The role of ultrasound methods in the assessment of biometric characteristics of the optic nerve

Российский офтальмологический журнал, 2020
The diagnostics of the optic nerve (ON) pathology relies on the results of clinical and instrumental examinations, electrophysiological tests, computer tomography and magnetic resonance imaging.
T. N. Kiseleva, A. V. Baeva, E. K. Eliseeva, V. V. Makukhina   +3 more
doaj   +1 more source

Analysis of Soluble Interleukin‐2 Receptor as a Prognostic Biomarker in NMOSD and MOGAD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Soluble interleukin‐2 receptor (sIL‐2R) is a biomarker for T cell activity. T cells are involved in neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) pathogenesis. However, sIL‐2R has so far not been evaluated in these conditions.
Philipp Klyscz, Carolin Otto, Klemens Ruprecht, Susanna Asseyer, Hannes Ole Tiedt, Christian Meisel, Judith Bellmann‐Strobl, Friedemann Paul, Patrick Schindler   +8 more
wiley   +1 more source

Toward Non-Invasive Electrical Stimulation for Guided Optic Nerve Regeneration

IEEE Transactions on Neural Systems and Rehabilitation Engineering
The optic nerve plays a critical role in visual information processing by relaying signals from the retina to the brain. Diseases affecting the optic nerve, such as glaucoma, can severely impair vision due to the nerve’s limited capacity for self ...
Pooyan Pahlavan, Peter S. Mayer, Anahit Simonyan, Jonathon Cavaleri, Connie Huang, Robert Grady Briggs, Gabriel Zada, Darrin J. Lee, Kimberly K. Gokoffski, Gianluca Lazzi   +9 more
doaj   +1 more source

mTORC2 activation protects retinal ganglion cells via Akt signaling after autophagy induction in traumatic optic nerve injury

Experimental and Molecular Medicine, 2019
Eye disease: switching signals for repairing injured optic nerves Regulating molecular signaling pathways that control the degradation of cellular components—a process known as autophagy—could offer a new approach to treating optic nerve damage after ...
Yao-Tseng Wen, Jia-Rong Zhang, Kishan Kapupara, Rong-Kung Tsai   +3 more
doaj   +1 more source

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

Ophthalmic Manifestations of Hematopoietic Malignancy

Case Reports in Ophthalmological Medicine, 2016
Purpose. To report the ocular findings in patients with hematopoietic malignancy with optic nerve involvement and abducens nerve palsy. Methods. The medical records of all cases of hematopoietic cancer with ophthalmic involvements seen in the Department ...
Natsuyo Yoshida-Hata, Naomichi Katai, Toshiyuki Oshitari   +2 more
doaj   +1 more source

The progress in optic nerve regeneration, where are we?

Neural Regeneration Research, 2016
Optic nerve regeneration is an important area of research. It can be used to treat patients suffering from optic neuropathy and provides insights into the treatment of numerous neurodegenerative diseases.
Jennifer Wei Huen Shum, Kai Liu, Kwok-fai So   +2 more
doaj   +1 more source