Results 61 to 70 of about 2,659,383 (253)

Robust and interpretable unit level causal inference in neural networks for pediatric myopia

npj Digital Medicine
Understanding causal mechanisms in deep learning is essential for clinical adoption, where interpretability and reliability are critical. Most existing AI systems act as black boxes, limiting transparency in medicine.
Zihui Jin, Mengtian Kang, Wuyan Zhao, Wenjin Gui, He Li, Yongfang Tu, Yongjun Huo, Canqing Yu, Weihua Song, Ningli Wang, Xu Yang, Shi-Ming Li   +11 more
doaj   +1 more source

MEDICAL AND SOCIAL ISSUES OF OCCUPATIONAL REHABILITATION IN ELDERLY PATIENTS WITH VASCULAR OPHTHALMOPATHY

Alʹmanah Kliničeskoj Mediciny, 2016
Aim: To assess medical and social issues of occupational rehabilitation in elderly patients with vascular eye diseases. Materials and methods: The results of examination of 572 patients and disabled persons after acute occlusion of central retinal artery,
A. M. Razumovskaya, M. I. Razumovskiy, S. V. Trofimova   +2 more
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

The contribution of brain reorganisation to recovery in patients with optic neuritis [PDF]

, 2010
In this thesis, the mechanisms of damage and repair in clinically isolated optic neuritis (ON) were investigated in vivo, by combining magnetic resonance imaging (MRI), electrophysiology and optical coherence tomography (OCT).
Jenkins, T.M.
core  

Can automated imaging for optic disc and retinal nerve fiber layer analysis aid glaucoma detection? [PDF]

, 2016
Open Access funded by Department of Health UKPurpose: To compare the diagnostic performance of automated imaging for glaucoma. Design: Prospective, direct comparison study.
Banister, K, Burr, JM, McMeekin, P, Gray, J, Jonathan Cook (3435386), Rupert R. A. Bourne (3232398), Cook, Jonathan, Charles Boachie (725223), Garway-Heath, David, Joanne Gray (468122), Pete McMeekin (16670856), Hernández, Rodolfo, Ramsay, C, Gray, Joanne, Cook, J, McMeekin, Peter, Jennifer M. Burr (16657107), Ramsay, Craig, Burr, Jennifer, Katie Banister (8982902), Craig R. Ramsay (9096188), Hernández, R, David F. Garway-Heath (8770919), Boachie, Charles, Bourne, Rupert, Burr, Jennifer M., Azuara-Blanco, A, Banister, Katie, Garway-Heath, D, Azuara-Blanco, Augusto, Bourne, R, Augusto Azuara-Blanco (6328919), Rodolfo Hernández (16670859), Boachie, C   +33 more
core   +1 more source

Correlation of optic nerve and optic nerve sheath diameter with intracranial pressure in pigs. [PDF]

, 2020
OBJECTIVE Several studies have shown an association between intracranial pressure and the diameter of the optic nerve sheath measured by transbulbar ultrasonography. To understand the pathophysiology of this phenomenon, we aimed to measure the changes
J. Beck (8399460), C. Fung (8399454), I. Zubak (8399445), S. M. Jakob (8399457), W. J. Z’Graggen (8399463), J Beck, Jakob, S. M., Zubak, I., A. Schuetz (8399448), R Mija, I Zubak, S M Jakob, Schuetz, A., Z'Graggen, W. J., C Fung, M Glas, A Schuetz, R. Mija (8399442), Fung, C., Beck, J., Glas, M., Andreas Bloch, Bloch, Andreas, Mija, R., Andreas Bloch (5489834), M. Glas (8399451), W J Z'Graggen   +26 more
core   +2 more sources

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

ATF3 upregulation in glia during Wallerian degeneration: differential expression in peripheral nerves and CNS white matter [PDF]

, 2004
Background: Many changes in gene expression occur in distal stumps of injured nerves but the transcriptional control of these events is poorly understood.
Coffin, RS, Hossain-Ibrahim Kismet, Mason, MRJ, Lieberman AR, Lieberman, AR, Mason Matthew RJ, Hossain-Ibrahim, K, David Hunt, Winterbottom, J, Anderson, PN, Hunt David, AR Lieberman, Kismet Hossain-Ibrahim, Anderson PN, Coffin Robert S, Hunt, D, PN Anderson, Matthew RJ Mason, Robert S Coffin, Winterbottom Julia, Julia Winterbottom   +20 more
core   +1 more source