Results 1 to 10 of about 107,837 (281)

miRNA Changes in Retinal Ganglion Cells after Optic Nerve Crush and Glaucomatous Damage

Cells, 2021
The purpose of this study was to characterize the miRNA profile of purified retinal ganglion cells (RGC) from healthy and diseased rat retina. Diseased retina includes those after a traumatic optic nerve crush (ONC), and after ocular hypertension ...
Ben Mead, Alicia Kerr, Naoki Nakaya, Stanislav I. Tomarev   +3 more
doaj   +1 more source

Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. [PDF]

PLoS Genetics, 2005
In glaucoma, harmful intraocular pressure often contributes to retinal ganglion cell death. It is not clear, however, if intraocular pressure directly insults the retinal ganglion cell axon, the soma, or both.
Richard T Libby, Yan Li, Olga V Savinova, Joseph Barter, Richard S Smith, Robert W Nickells, Simon W M John   +6 more
doaj   +2 more sources

Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma. [PDF]

PLoS ONE, 2013
Glaucoma is a complex disease affecting an estimated 70 million people worldwide, characterised by the progressive degeneration of retinal ganglion cells and accompanying visual field loss.
Pete A Williams, Gareth R Howell, Jessica M Barbay, Catherine E Braine, Gregory L Sousa, Simon W M John, James E Morgan   +6 more
doaj   +1 more source

Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection

Acta Neuropathologica Communications, 2023
Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in physiological range.
Alessio Canovai, James R. Tribble, Melissa Jöe, Daniela Y. Westerlund, Rosario Amato, Ian A. Trounce, Massimo Dal Monte, Pete A. Williams   +7 more
doaj   +1 more source

Selective deletion of zinc transporter 3 in amacrine cells promotes retinal ganglion cell survival and optic nerve regeneration after injury

Neural Regeneration Research, 2023
[INLINE:1] Vision depends on accurate signal conduction from the retina to the brain through the optic nerve, an important part of the central nervous system that consists of bundles of axons originating from retinal ganglion cells.
Zhe Liu, Jingfei Xue, Canying Liu, Jiahui Tang, Siting Wu, Jicheng Lin, Jiaxu Han, Qi Zhang, Caiqing Wu, Haishun Huang, Ling Zhao, Yehong Zhuo, Yiqing Li   +12 more
doaj   +1 more source

Distinct roles for inhibition in spatial and temporal tuning of local edge detectors in the rabbit retina. [PDF]

, 2014
This paper examines the role of inhibition in generating the receptive-field properties of local edge detector (LED) ganglion cells in the rabbit retina. We confirm that the feed-forward inhibition is largely glycinergic but, contrary to a recent report,
Buldyrev, Ilya, Sivyer, Benjamin, Taylor, Rowland, Van Wyk, Michiel, Vaney, David, Venkataramani, Sowmya   +5 more
core   +7 more sources

Peritoneal macrophages attenuate retinal ganglion cell survival and neurite outgrowth

Neural Regeneration Research, 2021
Inflammation is a critical pathophysiological process that modulates neuronal survival in the central nervous system after disease or injury. However, the effects and mechanisms of macrophage activation on neuronal survival remain unclear. In the present
Jia-Jian Liang, Yu-Fen Liu, Tsz Kin Ng, Ci-Yan Xu, Mingzhi Zhang, Chi Pui Pang, Ling-Ping Cen   +6 more
doaj   +1 more source

Inhibition of BDNF-AS Provides Neuroprotection for Retinal Ganglion Cells against Ischemic Injury. [PDF]

PLoS ONE, 2016
Brain-derived neurotrophic factor (BDNF) protects retinal ganglion cells against ischemia in ocular degenerative diseases. We aimed to determine the effect of BDNF-AS on the ischemic injury of retinal ganglion cells.The levels of BDNF and BDNF-AS were ...
Lifang Xu, Ziyin Zhang, Tianhua Xie, Xiaoyang Zhang, Tu Dai   +4 more
doaj   +1 more source

Adamts10 controls transforming growth factor β family signaling that contributes to retinal ganglion cell development

Frontiers in Molecular Biosciences, 2022
Although mutations in ADAMTS10 have long been known to cause autosomal recessive Weill-Marchesani Syndrome which is characterized by short stature and ocular abnormalities, more recent work has shown that certain mutations in ADAMTS10 cause glaucoma in ...
Lauren K. Wareham, Amy E. Whitener, Hang-Jing Wu, Shu-Yu Wu, Hassane S. Mchaourab, Douglas P. Mortlock, Rachel W. Kuchtey, Rachel W. Kuchtey, John Kuchtey   +8 more
doaj   +1 more source

Lepidium sativum as candidate against excitotoxicity in retinal ganglion cells

Translational Neuroscience, 2021
Glutamate excitotoxicity is considered one of the major causes of retinal ganglion cell death in many retinal diseases. Retinal ganglion cell degeneration causes severe blindness since visual signals from the eye to the brain are conducted only through ...
Al-Dbass Abeer, Amina Musarat, Al Musayeib Nawal M., El-Anssary Amira A., Bhat Ramesa Shafi, Fahmy Rania, Alhamdan Majd M., El-Ansary Afaf   +7 more
doaj   +1 more source