Results 1 to 10 of about 72,734 (313)
Activation of BMP-Smad1/5/8 signaling promotes survival of retinal ganglion cells after damage in vivo. [PDF]
PLoS ONE, 2012 While the essential role of bone morphogenetic protein (BMP) signaling in nervous system development is well established, its function in the adult CNS is poorly understood.
Yumi Ueki, Thomas A Reh
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PTEN Expression Regulates Gap Junction Connectivity in the Retina
Frontiers in Neuroanatomy, 2021 Manipulation of the phosphatase and tensin homolog (PTEN) pathway has been suggested as a therapeutic approach to treat or prevent vision loss due to retinal disease.
Ashley M. Chen +7 more
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Neurogenesis and Specification of Retinal Ganglion Cells [PDF]
International Journal of Molecular Sciences, 2020 Across all species, retinal ganglion cells (RGCs) are the first retinal neurons generated during development, followed by the other retinal cell types. How are retinal progenitor cells (RPCs) able to produce these cell types in a specific and timely order?
Nguyen-Ba-Charvet, Kim Tuyen +1 more
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Journal of Ophthalmology, 2015 Purpose. To assess the repeatability of spectral-domain optical coherence tomography to measure macular and perimacular ganglion cell complex thicknesses and compare retinal ganglion cell parameters between algorithms. Methods. Ninety-two nonglaucomatous
Dorothy S. K. Ng +6 more
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Neural Regeneration ResearchRetinal ganglion cells are susceptible to neurodegenerative conditions and their death drives common forms of irreversible vision loss. In mice, there are 46 transcriptionally unique retinal ganglion cell types that demonstrate different susceptibilities
Allison L. Hall +7 more
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Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice. [PDF]
PLoS ONE, 2013 Impairment of visual function has been detected in the early stage of diabetes but the underlying neural mechanisms involved are largely unknown.
Jun Yu +5 more
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Cell transplantation to replace retinal ganglion cells faces challenges – the Switchboard Dilemma
Neural Regeneration Research, 2021 The mammalian retina displays incomplete intrinsic regenerative capacities; therefore, retina degeneration is a major cause of irreversible blindness such as glaucoma, age-related macular degeneration and diabetic retinopathy.
Yuan Liu, Richard K Lee
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R-28 cell-derived extracellular vesicles protect retinal ganglion cells in glaucoma
Neural Regeneration ResearchGlaucoma is characterized by chronic progressive optic nerve damage and retinal ganglion cell death. Although extensive research has been conducted on neuroprotection for retinal ganglion cells, there is still no treatment for clinical use.
Esmahan Durmaz +5 more
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PANoptosis of Retinal Ganglion Cells
Journal of Integrative NeurosciencePANoptosis represents a novel form of programmed cell death regulated and controlled by the PANoptosome. It encompasses the essential features of apoptosis, necroptosis, and pyroptosis and combines elements from each process. PANoptosis contributes to the development of various diseases, including bacterial and viral infections, tumors, inflammatory ...
Xuejing Lu +3 more
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Molecular Phenotyping of Retinal Ganglion Cells [PDF]
The Journal of Neuroscience, 2002 Classifying all of the ganglion cells in the mammalian retina has long been a goal of anatomists, physiologists, and cell biologists. The rabbit retinal ganglion cell layer was phenotyped using intrinsic small molecule signals (aspartate, glutamate, glycine, glutamine, GABA, and taurine) and glutamate receptor-gated 1-amino-4-guanidobutane excitation ...
Robert E, Marc, Bryan W, Jones
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