Elevated expression of human bHLH factor ATOH7 accelerates cell cycle progression of progenitors and enhances production of avian retinal ganglion cells. [PDF]
, 2018 The production of vertebrate retinal projection neurons, retinal ganglion cells (RGCs), is regulated by cell-intrinsic determinants and cell-to-cell signaling events.
Hashimoto, Takao +3 more
core +1 more source
Molecular Brain, 2018 Retinal ganglion cell dendritic atrophy is an early feature of glaucoma, and the recovery of retinal ganglion cell dendrites is a viable option for vision improvement in glaucoma.
James R. Tribble +4 more
doaj +1 more source
Non-viral delivery and optimized optogenetic stimulation of retinal ganglion cells led to behavioral restoration of vision [PDF]
, 2012 Stimulation of retinal neurons using optogenetics via use of chanelrhodopsin-2 (ChR2) has opened up a new direction for restoration of vision for treatment of retinitis pigmentosa (RP).
Edward Wong +5 more
core +2 more sources
Scientific Reports, 2021 Optic neuropathies such as glaucoma are characterized by retinal ganglion cell (RGC) degeneration and death. The sigma-1 receptor (S1R) is an attractive target for treating optic neuropathies as it is highly expressed in RGCs, and its absence causes ...
Michal Geva +7 more
doaj +1 more source
Dendritic and axonal targeting patterns of a genetically-specified class of retinal ganglion cells that participate in image-forming circuits. [PDF]
, 2014 BackgroundThere are numerous functional types of retinal ganglion cells (RGCs), each participating in circuits that encode a specific aspect of the visual scene.
Feldheim, David A +6 more
core +2 more sources
Activation of BMP-Smad1/5/8 signaling promotes survival of retinal ganglion cells after damage in vivo. [PDF]
PLoS ONE, 2012 While the essential role of bone morphogenetic protein (BMP) signaling in nervous system development is well established, its function in the adult CNS is poorly understood.
Yumi Ueki, Thomas A Reh
doaj +1 more source
PTEN Expression Regulates Gap Junction Connectivity in the Retina
Frontiers in Neuroanatomy, 2021 Manipulation of the phosphatase and tensin homolog (PTEN) pathway has been suggested as a therapeutic approach to treat or prevent vision loss due to retinal disease.
Ashley M. Chen +7 more
doaj +1 more source
RdgB2 is required for dim-light input into intrinsically photosensitive retinal ganglion cells. [PDF]
, 2015 A subset of retinal ganglion cells is intrinsically photosensitive (ipRGCs) and contributes directly to the pupillary light reflex and circadian photoentrainment under bright-light conditions.
Berson, David M +8 more
core +2 more sources
Transformation of stimulus correlations by the retina [PDF]
, 2013 Redundancies and correlations in the responses of sensory neurons seem to waste neural resources but can carry cues about structured stimuli and may help the brain to correct for response errors.
Balasubramanian, V. +7 more
core +7 more sources
Journal of Ophthalmology, 2015 Purpose. To assess the repeatability of spectral-domain optical coherence tomography to measure macular and perimacular ganglion cell complex thicknesses and compare retinal ganglion cell parameters between algorithms. Methods. Ninety-two nonglaucomatous
Dorothy S. K. Ng +6 more
doaj +1 more source