Results 11 to 20 of about 5,405,992 (262)

Retinal ganglion cell shrinkage in glaucoma

Journal of Glaucoma, 2002
SUMMARY: There has been some debate concerning the selective loss of retinal ganglion cells belonging to the magnocellular pathway in early glaucoma.
Morgan, James Edwards
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Intrinsically Photosensitive Retinal Ganglion Cells [PDF]

Science China Life Sciences, 2010
A new mammalian photoreceptor was recently discovered to reside in the ganglion cell layer of the inner retina. These intrinsically photosensitive retinal ganglion cells (ipRGCs) express a photopigment, melanopsin that confers upon them the ability to respond to light in the absence of all rod and cone photoreceptor input.
Pickard, Gary E., Sollars, Patricia J.
openaire   +6 more sources

Protecting retinal ganglion cells [PDF]

Eye, 2017
Retinal ganglion cell degeneration underlies several conditions which give rise to significant visual compromise, including glaucoma, hereditary optic neuropathies, ischaemic optic neuropathies, and demyelinating disease. In this review, we discuss the emerging strategies for neuroprotection specifically in the context of glaucoma, including ...
T Z, Khatib, K R, Martin
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Retinal ganglion cells in diabetes [PDF]

The Journal of Physiology, 2008
Diabetic retinopathy has long been recognized as a vascular disease that develops in most patients, and it was believed that the visual dysfunction that develops in some diabetics was due to the vascular lesions used to characterize the disease. It is becoming increasingly clear that neuronal cells of the retina also are affected by diabetes, resulting
Timothy S, Kern, Alistair J, Barber
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Advances in retinal ganglion cell imaging [PDF]

Eye, 2015
Glaucoma is one of the leading causes of blindness worldwide and will affect 79.6 million people worldwide by 2020. It is caused by the progressive loss of retinal ganglion cells (RGCs), predominantly via apoptosis, within the retinal nerve fibre layer and the corresponding loss of axons of the optic nerve head.
S I, Balendra, E M, Normando, P A, Bloom, M F, Cordeiro   +3 more
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Long-term gene therapy causes transgene-specific changes in the morphology of regenerating retinal ganglion cells [PDF]

, 2012
Recombinant adeno-associated viral (rAAV) vectors can be used to introduce neurotrophic genes into injured CNS neurons, promoting survival and axonal regeneration.
Rodger Jennifer, Hellström Mats, Alan R Harvey, Jennifer Rodger, Mats Hellström, Hellström, M., Robertson, D., Harvey, A.R., Donald Robertson, Drummond Eleanor S., Harvey Alan R., Eleanor S Drummond, Rodger, J., Drummond, E.S., Robertson Donald   +14 more
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Cell-Based Neuroprotection of Retinal Ganglion Cells in Animal Models of Optic Neuropathies

Biology, 2021
Retinal ganglion cells (RGCs) comprise a heterogenous group of projection neurons that transmit visual information from the retina to the brain. Progressive degeneration of these cells, as it occurs in inflammatory, ischemic, traumatic or glaucomatous ...
Yue Hu, Lynn Michelle Grodzki, Susanne Bartsch, Udo Bartsch   +3 more
doaj   +1 more source

Adult limbal neurosphere cells: a potential autologous cell resource for retinal cell generation [PDF]

, 2014
The Corneal limbus is a readily accessible region at the front of the eye, separating the cornea and sclera. Neural colonies (neurospheres) can be generated from adult corneal limbus in vitro.
Jessica Cooke (637632), Jennifer Scott, Heather Thomson, Xiaoli Chen, Lotery, Andrew J., Xiaoli Chen (102563), Cooke, J.J., Scott, Jennifer A., Andrew Lotery, Heather Thomson (637631), Thomson, Heather, Jessica Cooke, Parwez Hossain, Jennifer Scott (637633), Chen, Xiaoli, Hossain, Parwez, Andrew Lotery (637635), Parwez Hossain (637634), Cooke Jessica, Lotery Andrew, Thomson Heather, Hossain Parwez, Chen Xiaoli, Scott Jennifer   +23 more
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Atoh7-independent specification of retinal ganglion cell identity [PDF]

, 2021
Retinal ganglion cells (RGCs) relay visual information from the eye to the brain. RGCs are the first cell type generated during retinal neurogenesis.
Ruzycki, Philip A, Clark, Brian S, Shiau, Fion, et al,, Brodie-Kommit, Justin, Sheely, Catherine, Glaser, Tom, Javed, Awais, Badea, Tudor, Fries, Michel, Cayouette, Michel, Shi, Qing, Schmidt, Tiffany, Singer, Joshua, Zhao, Haiqing, Blackshaw, Seth, Langel, Jennifer, Kim, Dong Won, Hattar, Samer, Joshua Singer, Michel Fries, Brian S. Clark, Samer Hattar, Tudor Badea, Tiffany Schmidt, Dong Won Kim, Haiqing Zhao, Michel Cayouette, Tom Glaser, Justin Brodie-Kommit, Catherine Sheely, Philip A Ruzycki, Seth Blackshaw, Awais Javed, Jennifer Langel, Qing Shi, Fion Shiau   +36 more
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Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma

Molecular Brain, 2018
Retinal ganglion cell dendritic atrophy is an early feature of glaucoma, and the recovery of retinal ganglion cell dendrites is a viable option for vision improvement in glaucoma.
James R. Tribble, Pete A. Williams, Bruce Caterson, Frank Sengpiel, James E. Morgan   +4 more
doaj   +1 more source