Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes [PDF]
, 2005 Development of the retinal vasculature is controlled by a hierarchy of interactions among retinal neurons, astrocytes and blood vessels. Retinal neurons release platelet-derived growth factor (PDGFA) to stimulate proliferation of astrocytes, which in ...
Heloise West +5 more
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Encoding of saccadic scene changes in the mouse retina [PDF]
, 2012 The task of the visual system is to extract behaviourally relevant information from the visual scene. A common strategy for most animals ranging from insects to humans is to constantly reposition gaze by making saccades within the scene. This ‘fixate and
Krishnamoorthy, Vidhyasankar
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Neural Regeneration ResearchRetinal ganglion cells are susceptible to neurodegenerative conditions and their death drives common forms of irreversible vision loss. In mice, there are 46 transcriptionally unique retinal ganglion cell types that demonstrate different susceptibilities
Allison L. Hall +7 more
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Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice. [PDF]
PLoS ONE, 2013 Impairment of visual function has been detected in the early stage of diabetes but the underlying neural mechanisms involved are largely unknown.
Jun Yu +5 more
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Nel positively regulates the genesis of retinal ganglion cells by promoting their differentiation and survival during development [PDF]
, 2014 Peer ...
Findlay, Amy S. +10 more
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On the Generation and Regeneration of Retinal Ganglion Cells [PDF]
Frontiers in Cell and Developmental Biology, 2020 Retinal development follows a conserved neurogenic program in vertebrates to orchestrate the generation of specific cell types from multipotent progenitors in sequential but overlapping waves. In this program, retinal ganglion cells (RGCs) are the first cell type generated.
Viviane M. Oliveira-Valença +4 more
openaire +4 more sources
R-28 cell-derived extracellular vesicles protect retinal ganglion cells in glaucoma
Neural Regeneration ResearchGlaucoma is characterized by chronic progressive optic nerve damage and retinal ganglion cell death. Although extensive research has been conducted on neuroprotection for retinal ganglion cells, there is still no treatment for clinical use.
Esmahan Durmaz +5 more
doaj +1 more source
Cell transplantation to replace retinal ganglion cells faces challenges – the Switchboard Dilemma
Neural Regeneration Research, 2021 The mammalian retina displays incomplete intrinsic regenerative capacities; therefore, retina degeneration is a major cause of irreversible blindness such as glaucoma, age-related macular degeneration and diabetic retinopathy.
Yuan Liu, Richard K Lee
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Encoding surprise by retinal ganglion cells
PLOS Computational Biology, 2022 The efficient coding hypothesis posits that early sensory neurons transmit maximal information about sensory stimuli, given internal constraints. A central prediction of this theory is that neurons should preferentially encode stimuli that are most surprising.
Danica Despotović +3 more
openaire +4 more sources
Damage and repair in retinal degenerative diseases: Molecular basis through clinical translation
Neural Regeneration ResearchRetinal ganglion cells are the bridging neurons between the eye and the central nervous system, transmitting visual signals to the brain. The injury and loss of retinal ganglion cells are the primary pathological changes in several retinal degenerative ...
Ziting Zhang +5 more
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