Results 51 to 60 of about 107,837 (281)

Retinal Ganglion Cell Death

, 2011
1.1 Topographic and cellular organization of the retina The retina is the thin (0.2 mm) lining of the back of the eye that gathers light focused on it by the cornea and lens. The retina has a complex laminar organization; cells are organized into layers (Fig. 1). These layers are named by reference to the middle of the eyeball; the innermost layers are
Yasemin Budak, Muberra Akdog
openaire   +4 more sources

Large-scale multielectrode recording and stimulation of neural activity [PDF]

, 2007
Large circuits of neurons are employed by the brain to encode and process information. How this encoding and processing is carried out is one of the central questions in neuroscience.
Chichilnisky, E. J., Dabrowski, W., Grillo, A. A., Grivich, M., Gunning, D., Hottowy, P., Kachiguine, S., Litke, A. M., Mathieson, K., Petrusca, D., Sher, A.   +10 more
core   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Normative Data and Minimally Detectable Change for Inner Retinal Layer Thicknesses Using a Semi-automated OCT Image Segmentation Pipeline [PDF]

, 2019
Neurodegenerative and neuroinflammatory diseases regularly cause optic nerve and retinal damage. Evaluating retinal changes using optical coherence tomography (OCT) in diseases like multiple sclerosis has thus become increasingly relevant.
Asseyer, Susanna, Ayadi, Noah, Bereuter, Charlotte, Brandt, Alexander Ulrich, Gawlik, Kay, Kadas, Ella Maria, Mikolajczak, Janine, Motamedi, Seyedamirhosein, Paul, Friedemann, Zimmermann, Hanna G.   +9 more
core   +2 more sources

Molecular Phenotyping of Retinal Ganglion Cells [PDF]

The Journal of Neuroscience, 2002
Classifying all of the ganglion cells in the mammalian retina has long been a goal of anatomists, physiologists, and cell biologists. The rabbit retinal ganglion cell layer was phenotyped using intrinsic small molecule signals (aspartate, glutamate, glycine, glutamine, GABA, and taurine) and glutamate receptor-gated 1-amino-4-guanidobutane excitation ...
Robert E, Marc, Bryan W, Jones
openaire   +2 more sources

Neuromorphic Electronics for Intelligence Everywhere: Emerging Devices, Flexible Platforms, and Scalable System Architectures

Advanced Materials, EarlyView.
The perspective presents an integrated view of neuromorphic technologies, from device physics to real‐time applicability, while highlighting the necessity of full‐stack co‐optimization. By outlining practical hardware‐level strategies to exploit device behavior and mitigate non‐idealities, it shows pathways for building efficient, scalable, and ...
Kapil Bhardwaj, Roshni Satheesh Babu, Yuxin Xia, Eva Bestelink, Radu Sporea, Nikos Hastas, Ioannis Zeimpekis, Dimitra G. Georgiadou, Sayani Majumdar   +8 more
wiley   +1 more source

Neuronal Nitric Oxide Synthase Is Crucial for Ganglion Cell Death in Rat Retinal Explant Cultures

Journal of Pharmacological Sciences, 2004
We examined possible involvement of nitric oxide synthase (NOS) on ganglion cell death in explant cultures of neonatal rat retina. Survival of retinal ganglion cells was significantly prolonged by a broad-spectrum NOS inhibitor Nω-nitro-L-arginine ...
Hiroshi Katsuki, Rie Yamamoto, Daisuke Nakata, Toshiaki Kume, Akinori Akaike   +4 more
doaj   +1 more source

Neuroprotective Effect of Tauroursodeoxycholic Acid on N-Methyl-D-Aspartate-Induced Retinal Ganglion Cell Degeneration. [PDF]

PLoS ONE, 2015
Retinal ganglion cell degeneration underlies the pathophysiology of diseases affecting the retina and optic nerve. Several studies have previously evidenced the anti-apoptotic properties of the bile constituent, tauroursodeoxycholic acid, in diverse ...
Violeta Gómez-Vicente, Pedro Lax, Laura Fernández-Sánchez, Netxibeth Rondón, Gema Esquiva, Francisco Germain, Pedro de la Villa, Nicolás Cuenca   +7 more
doaj   +1 more source

Engineered Living Systems With Self‐Organizing Neural Networks: From Anatomy to Behavior and Gene Expression

Advanced Science, EarlyView.
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat, Laurie O'Neill, Léo Pio‐Lopez, Megan M. Sperry, Patrick Erickson, Tiffany Lin, Michael Levin   +6 more
wiley   +1 more source

Molecular mechanisms after optic nerve injury: Neurorepair strategies from a transcriptomic perspective

Neural Regeneration Research
Retinal ganglion cells, a crucial component of the central nervous system, are often affected by irreversible visual impairment due to various conditions, including trauma, tumors, ischemia, and glaucoma.
Xiaxue Chen, Muyang Wei, Guangyu Li
doaj   +1 more source