Results 1 to 10 of about 1,469,459 (252)

Application of Proteomics Analysis and Animal Models in Optic Nerve Injury Diseases [PDF]

Brain Sciences, 2023
Optic nerve damage is a common cause of blindness. Optic nerve injury is often accompanied by fundus vascular disease, retinal ganglion cell apoptosis, and changes in retinal thickness.
Zhaoyang Meng, Ran You, Arif Mahmood, Fancheng Yan, Yanling Wang   +4 more
doaj   +5 more sources

Sheath-Preserving Complete Optic Nerve Avulsion Following Closed-Globe Injury: A Case Report

Türk Oftalmoloji Dergisi, 2022
A 29-year-old man presented with a sudden loss of vision after a closed-globe injury. At presentation, he had no light perception in the right eye and the right pupil was dilated and nonreactive to light.
Seray Şahin, Onur Furundaoturan, Mine Esen Barış, Elif Demirkılınç Biler   +3 more
doaj   +2 more sources

Molecular mechanisms after optic nerve injury: Neurorepair strategies from a transcriptomic perspective [PDF]

Neural Regeneration Research
Retinal ganglion cells, a crucial component of the central nervous system, are often affected by irreversible visual impairment due to various conditions, including trauma, tumors, ischemia, and glaucoma.
Xiaxue Chen, Muyang Wei, Guangyu Li
doaj   +2 more sources

Localized co-delivery of CNTF and FK506 using a thermosensitive hydrogel for retina ganglion cells protection after traumatic optic nerve injury

Drug Delivery, 2020
Following the traumatic axonal injury in the optic nerve, the failure of retrograde axonal transport to continuously supply neurotrophins from the brain to retina results in deprivation of neurotrophins in retinal ganglion cells (RGCs), which in turn can
Dongmei Wang, Mengmeng Luo, Baoshan Huang, Wa Gao, Yan Jiang, Qing Li, Kaihui Nan, Sen Lin   +7 more
doaj   +2 more sources

A novel animal model of partial optic nerve transection established using an optic nerve quantitative amputator. [PDF]

PLoS ONE, 2012
BACKGROUND: Research into retinal ganglion cell (RGC) degeneration and neuroprotection after optic nerve injury has received considerable attention and the establishment of simple and effective animal models is of critical importance for future progress.
Xu Wang, Ying Li, Yan He, Hong-Sheng Liang, En-Zhong Liu   +4 more
doaj   +1 more source

The Biomechanics of Indirect Traumatic Optic Neuropathy Using a Computational Head Model With a Biofidelic Orbit

Frontiers in Neurology, 2020
Indirect traumatic optic neuropathy (ITON) is an injury to the optic nerve due to head trauma and usually results in partial or complete loss of vision. In order to advance a mechanistic understanding of the injury to the optic nerve, we developed a head
Yang Li, Yang Li, Eric Singman, Timothy McCulley, Chengwei Wu, Nitin Daphalapurkar, Nitin Daphalapurkar   +6 more
doaj   +1 more source

Microglial SIRT1 activation attenuates synapse loss in retinal inner plexiform layer via mTORC1 inhibition

Journal of Neuroinflammation, 2023
Background Optic nerve injury (ONI) is a key cause of irreversible blindness and triggers retinal ganglion cells (RGCs) change and synapse loss. Microglia is the resistant immune cell in brain and retina and has been demonstrated to be highly related ...
Ke Yao, Qianxue Mou, Xiaotong Lou, Meng Ye, Bowen Zhao, Yuanyuan Hu, Jing Luo, Hong Zhang, Xing Li, Yin Zhao   +9 more
doaj   +1 more source

Optic nerve sheath diameter measurement using point-of-care ultrasound to assess intracranial pressure of adult patients with traumatic brain injury in resource-limited setting

Interdisciplinary Neurosurgery, 2023
Background: Traumatic brain injury is a disease with high mortality with increased intracranial pressure included in the emergency department. Neuroimaging and intracranial pressure monitoring are limited in resource-limited settings.
Melaku Getachew, Mohammednur Abdulahi, Natan Muluberehan, Zeynu Hussen, Amanuel Alemayehu, Tiliksew Abebe, Abdulaziz Hussein, Peter Hutchinson, Angelos Kolias, Mulugeta Semework, Abenezer Tirsit, Tsegazeab Laeke, Abraham Tadela, Getaw Worku Hassen   +13 more
doaj   +1 more source

Traumatic optic neuropathy: Surgical intervention improves vision and color perception

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2018
The most common cause of traumatic optic neuropathy (TON) is indirect injury to the optic nerve, which is thought to be the result of transmitted shock from an orbital impact to the intracanalicular portion of optic nerve.
Sujit Das
doaj   +1 more source

Assessment of outer retinal thickness and function in mice after experimental optic nerve trauma

BMC Ophthalmology, 2022
Background Optic nerve trauma caused by crush injury is frequently used for investigating experimental treatments that protect retinal ganglion cells (RGCs) and induce axonal regrowth.
Karin Rose Lypka, Tal Carmy-Bennun, Kimberly N. Garces, Alexander W. Venanzi, Abigail S. Hackam   +4 more
doaj   +1 more source