Results 61 to 70 of about 137,284 (347)

TRPV1 Tunes Optic Nerve Axon Excitability in Glaucoma

Frontiers in Physiology, 2020
The transient receptor potential vanilloid member 1 (TRPV1) in the central nervous system may contribute to homeostatic plasticity by regulating intracellular Ca2+, which becomes unbalanced in age-related neurodegenerative diseases, including Alzheimer’s
Nolan R. McGrady, Michael L. Risner, Victoria Vest, David J. Calkins   +3 more
doaj   +1 more source

A Novel Reporter Mouse Uncovers Endogenous Brn3b Expression. [PDF]

, 2019
Brn3b (Pou4f2) is a class-4 POU domain transcription factor known to play central roles in the development of different neuronal populations of the Central Nervous System, including retinal ganglion cells (RGCs), the neurons that connect the retina with ...
Cheema, Simranjeet K, La Torre, Anna, Mercado-Ayon, Yesica, Miltner, Adam M, Zawadzki, Robert J, Zhang, Pengfei   +5 more
core   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Evaluation of the progression of visual field damage in patients suffering from early manifest glaucoma [PDF]

, 2016
BACKGROUND: This retrospective study aimed to determine how often a perimetric examination should be carried out in order to identify visual field (VF) changes in patients with relatively early manifestation glaucoma.
Abdolrahimzadeh, S, CIARNELLA, Angela, CUTINI, ALESSANDRO, Perdicchi, A, SCUDERI, GIANLUCA   +4 more
core   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

The role of ultrasound methods in the assessment of biometric characteristics of the optic nerve

Российский офтальмологический журнал, 2020
The diagnostics of the optic nerve (ON) pathology relies on the results of clinical and instrumental examinations, electrophysiological tests, computer tomography and magnetic resonance imaging.
T. N. Kiseleva, A. V. Baeva, E. K. Eliseeva, V. V. Makukhina   +3 more
doaj   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Toward Non-Invasive Electrical Stimulation for Guided Optic Nerve Regeneration

IEEE Transactions on Neural Systems and Rehabilitation Engineering
The optic nerve plays a critical role in visual information processing by relaying signals from the retina to the brain. Diseases affecting the optic nerve, such as glaucoma, can severely impair vision due to the nerve’s limited capacity for self ...
Pooyan Pahlavan, Peter S. Mayer, Anahit Simonyan, Jonathon Cavaleri, Connie Huang, Robert Grady Briggs, Gabriel Zada, Darrin J. Lee, Kimberly K. Gokoffski, Gianluca Lazzi   +9 more
doaj   +1 more source

mTORC2 activation protects retinal ganglion cells via Akt signaling after autophagy induction in traumatic optic nerve injury

Experimental and Molecular Medicine, 2019
Eye disease: switching signals for repairing injured optic nerves Regulating molecular signaling pathways that control the degradation of cellular components—a process known as autophagy—could offer a new approach to treating optic nerve damage after ...
Yao-Tseng Wen, Jia-Rong Zhang, Kishan Kapupara, Rong-Kung Tsai   +3 more
doaj   +1 more source

Comparative lipid profiling dataset of the inflammation-induced optic nerve regeneration. [PDF]

, 2019
In adult mammals, retinal ganglion cells (RGCs) fail to regenerate following damage. As a result, RGCs die after acute injury and in progressive degenerative diseases such as glaucoma; this can lead to permanent vision loss and, eventually, blindness ...
Bhattacharya, Sanjoy K, Caprioli, Joseph, Kwong, Jacky MK, Piqueras, Maria, Stark, David T, Trzeciecka, Anna   +5 more
core   +1 more source