Results 91 to 100 of about 347,881 (287)

Familial Mediterranean fever associated with optic neuritis, successfully treated with anti-interleukin 1 agents

The Turkish Journal of Pediatrics, 2016
Familial Mediterranean fever (FMF) is an inherited periodic auto-inflammatory disease characterized by recurrent attacks of fever, synovitis and serositis. Ophthalmological manifestations of FMF are extremely rare.
Özge Başaran, Sevim Kavuncu, Alev Güven, Nermin Uncu, Banu Acar-Çelikel, Nilgün Çakar   +5 more
doaj   +1 more source

Timing and Predictive Value of Clinical Conditions Preceding Multiple Sclerosis in the UK Biobank

Annals of Clinical and Translational Neurology, Volume 12, Issue 10, Page 1952-1961, October 2025.
ABSTRACT Objectives Multiple sclerosis (MS) patients often experience a higher incidence of clinical conditions before diagnosis, suggesting a prodromal phase. However, their predictive value and temporal trajectories remain underexplored. We investigated these aspects using the large UK Biobank's population‐based cohort, which provided clinical ...
Andrea Nova, Teresa Fazia, Giovanni Di Caprio, Davide Gentilini, Luisa Bernardinelli, Roberto Bergamaschi   +5 more
wiley   +1 more source

Understanding Mechanisms of Whole Brain and Regional Grey Matter Atrophy in Children With MOGAD

Annals of Clinical and Translational Neurology, Volume 12, Issue 10, Page 1971-1982, October 2025.
ABSTRACT Objective To investigate the mechanisms driving whole brain and regional grey matter (GM) volume changes along with their clinical correlates in paediatric myelin oligodendrocyte glycoprotein antibody (MOG‐Ab)–associated disease (MOGAD). Methods One‐hundred‐nine paediatric MOGAD patients from two UK centres underwent MRI at attack nadir and ...
Ermelinda De Meo, Riccardo Nistri, Michael Eyre, Cheryl Hemingway, Ming Lim, Thomas Rossor, Asthik Biswas, Kshitij Mankad, Ata Siddiqui, Sniya Sudhakar, Declan Chard, Frederik Barkhof, Arman Eshaghi, Olga Ciccarelli, Yael Hacohen   +14 more
wiley   +1 more source

The astrocyte transcriptome in EAE optic neuritis shows complement activation and reveals a sex difference in astrocytic C3 expression

Scientific Reports, 2019
Multiple sclerosis (MS) is a neuroinflammatory multifocal disorder. Optic neuritis is common in MS and leads to visual disability. No current treatments repair this damage. Discerning gene expression changes within specific cell types in optic nerve (ON)
A. Tassoni, Vista Farkhondeh, Y. Itoh, N. Itoh, M. Sofroniew, R. Voskuhl   +5 more
semanticscholar   +1 more source

High‐Efficacy Treatment in Neuromyelitis Optica Specturm Disorder Patients With Seropositive AQP4 Antibodies—A Real‐World Study

Annals of Clinical and Translational Neurology, Volume 12, Issue 10, Page 1983-1991, October 2025.
ABSTRACT Objective To compare the effectiveness of high‐efficacy treatments (HET) and low‐efficacy treatments (LET) in NMOSD patients with anti‐aquaporin‐4 antibodies (AQP4‐ab). Methods In this multi‐center study, we analyzed 183 AQP4‐ab seropositive NMOSD patients who received immunosuppressive treatments (IST).
Xiang Li, Binbin Xue, Jia Li, Dewei Xie, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Xu Zhang, Junhui Xia, Jie Lin   +10 more
wiley   +1 more source

Comparative Effect of Standard Versus Extended Interval Dosing of Rituximab or Ocrelizumab in Multiple Sclerosis

Annals of Clinical and Translational Neurology, Volume 12, Issue 10, Page 2086-2096, October 2025.
ABSTRACT Objective We aimed to investigate the comparative effectiveness of standard versus personalized extended interval dosing of anti‐CD20 therapy on clinical and sub‐clinical outcomes in multiple sclerosis. Methods Clinical information was collected prospectively on Research Electronic Data Capture.
Nabil K. El Ayoubi, Fares Fahd, Hani Tamim, Salem Hannoun, Mark Bal, Elham El‐Hallak, Samia J. Khoury   +6 more
wiley   +1 more source

Frequency of Seroconversion in Aquaporin‐4 Antibody Testing: Insights From Real‐World Data

Annals of Clinical and Translational Neurology, Volume 12, Issue 10, Page 2158-2163, October 2025.
ABSTRACT Clinicians often repeat aquaporin‐4‐immunoglobulin G (AQP4‐IgG) testing in case of possible seroconversion. Compared with older, less sensitive immunofluorescence assays (IFA), cell‐based assays (CBA) offer higher sensitivity. This study assessed the frequency of seroconversion in a retrospective Cleveland Clinic cohort (2006–2024) of 451 ...
Tatchaporn Ongphichetmetha, Mengke Du, Nisa Vorasoot, Sean J. Pittock, Jeffrey A. Cohen, Amy Kunchok   +5 more
wiley   +1 more source

An unusual case of optic and chiasmal neuritis caused by hypersensitivity to mycobacterium: A case report [PDF]

Journal of Krishna Institute of Medical Sciences University
We describe Magnetic Resonance Imaging (MRI) findings in a 49-years-old female who presented with subacute visual loss. MRI findings were suggestive of optic neuritis and chiasmal neuritis. She had necrotic mediastinal lymphadenopathy which was diagnosed
Reetika Kapoor, Parag Patil, Rushikesh Naik, Varsha Rangankar   +3 more
doaj  

Quantifying visual pathway axonal and myelin loss in multiple sclerosis and neuromyelitis optica

NeuroImage: Clinical, 2016
Background: The optic nerve is frequently injured in multiple sclerosis and neuromyelitis optica, resulting in visual dysfunction, which may be reflected by measures distant from the site of injury.
Praveena Manogaran, Irene M. Vavasour, Alex P. Lange, Yinshan Zhao, Katrina McMullen, Alexander Rauscher, Robert Carruthers, David K.B. Li, Anthony L. Traboulsee, Shannon H. Kolind   +9 more
doaj   +1 more source

Retinal microvascular alterations in Alzheimer's disease: Linking blood plasma biomarkers and cerebral small vessel pathology

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract BACKGROUND Retinal microvascular alterations, detectable via color fundus photography (CFP), may reflect cerebral microvascular pathology in Alzheimer's disease (AD). However, their associations with blood‐based biomarkers and cerebral small vessel disease (SVD) remain unclear.
William Robert Kwapong, Ning Wu, Weihong Lin, Jianing Shen, Youjie Wang, Jiajing Qian, Caiyun Wen, Xiaoqian Luan, Yuntao Liu, Haoran Cheng, Huihua Qiu, Carol Y. Cheung, Chunwen Zheng, Yinhe Liu, Yunjun Yang, Vincent Mok, Zhen Wang   +16 more
wiley   +1 more source