Results 111 to 120 of about 7,956,506 (236)

Aniridia‐associated keratopathy: Clinical and molecular mechanisms of disease progression and emerging therapeutic targets

Acta Ophthalmologica, Volume 104, Issue 6, Page 604-615, September 2026.
Abstract Congenital aniridia is a rare genetic disorder primarily caused by pathogenic variants of the PAX6 gene. It leads to various panocular anomalies, including aniridia‐associated keratopathy (AAK). This review highlights recent insights into its pathogenesis, focusing on clinical staging, microstructural changes in the cornea and molecular ...
N. Szentmáry, S. Suiwal, M. Amini, F. N. Fries, A. Náray, L. Latta, Z. Li, S. Li, S. Liu, S. L. Hsu, S. Kundu, G. Tóth, S. Trusen, J. Zimmermann, B. Seitz, B. Käsmann‐Kellner, Z. Hoxha, A. Langenbucher, O. Stachs, M. Cortón‐Perez, K. Tory, A. Csorba, Z. Z. Nagy, M. C. Acosta, J. Gallar, M. Csidey, E. Maka, T. Stachon   +27 more
wiley   +1 more source

Bilateral Optic Neuritis After Bee Sting

, 2014
Corneal edema, hyphema, lens dislocation, iris atrophy, cataract and glaucoma cases due to bee sting are frequently reported. Optic neuropathy developing after a bee sting is rarely reported. A 46-year-old man applied to our clinic with visual loss.
Haluk Esgin, Turkyilmaz, Yusuf, Yusuf Türkyılmaz, Esgin, Haluk   +3 more
core   +1 more source

Predictive model for converting optic neuritis to multiple sclerosis; decision tree in focus.

PLoS ONE
BackgroundOptic neuritis (ON) can be an initial clinical presentation of multiple sclerosis This study aims to provide a practical predictive model for identifying at-risk ON patients in developing MS.MethodWe utilized data from the Optic Neuritis ...
Saeid Rasouli, Mohammad Sedigh Dakkali, Azim Ghazvini, Reza Azarbad, Mahdi Asani, Zahra Mirzaasgari, Mohammed Arish   +6 more
doaj   +1 more source

Cancer survivorship in malignant melanoma

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 9, Page e1291-e1308, September 2026.
Summary Robust long‐term survival data have transformed the prognosis of metastatic melanoma. For combination therapy with immune checkpoint inhibitors (ICIs), 10‐year melanoma‐specific survival rates now exceed 50 %, and durable disease control is achievable in a substantial proportion of patients, including those with brain metastases.
Markus Reitmajer, Susanne Dugas‐Breit, Chiara L. Blomen, Elisabeth Livingstone, Max Schlaak, Markus V. Heppt, Michael M. Sachse, Madlen Hörold, Friedegund Meier, Sebastian Haferkamp, Christian Apfelbacher, Georgia Schilling, Andrea von den Berg, Frank Meiss, Lisa Zimmer, Andrea Forschner   +15 more
wiley   +1 more source

The Cambridge Centre for Myelin Repair trial Two (CCMR Two): a trial protocol for a phase 2a, randomised, double-blind, placebo-controlled clinical trial of the ability of the combination of metformin and clemastine to promote remyelination in people with relapsing-remitting multiple sclerosis already on disease-modifying therapy

Trials
Background In multiple sclerosis (MS), progressive disability occurs following degeneration of demyelinated axons. A tractable approach to delay, prevent or reverse disability progression is through enhancement of endogenous remyelination.
Gioia Riboni-Verri, Christopher E. McMurran, Trisha Mukherjee, Cyrus Daruwalla, Jonathon Holland, Riddhima Gautam, Benson S. Chen, Emma Cutting, Wendi Qian, David MacManus, Declan T. Chard, J. William L. Brown, Alasdair J. Coles, Nick G. Cunniffe   +13 more
doaj   +1 more source

Intrathecal Plasma Cell Activity as Measured by the Kappa Free Light Chain Index Is Associated With Retinal Layer Atrophy in Early Multiple Sclerosis

European Journal of Neurology, Volume 33, Issue 9, September 2026.
Within the present study we provide evidence that a higher κ‐FLC index is associated with retinal layer atrophy as indicated by thinner pRNFL and GCIPL. FLC, free light chain; GCIPL, ganglion cell plus inner plexiform layer; pRNFL, peripapillary measured retinal nerve fiber layer.
Klaus Berek, Martin Schmidauer, Fabian Föttinger, Michael Auer, Thomas Berger, Franziska Di Pauli, Luisa Velez Escola, Thomas Hofer, Barnabas Kremser, Stephanie Mangesius, Jan P. Nolte, Marie‐Christine Pali, Berthold Pemp, Katharina Stock, Markus Tiefenthaler, Janette Walde, Anne Zinganell, Florian Deisenhammer, Gabriel Bsteh, Harald Hegen   +19 more
wiley   +1 more source

Measuring and predicting the effect of remyelinating therapy in multiple sclerosis: a randomised controlled trial protocol (RESTORE)

BMJ Open
Introduction Remyelination failure hampers symptomatic recovery in multiple sclerosis (MS), underlining the importance of developing remyelinating therapies. Optic neuritis is currently the most established method of measuring remyelination in MS trials.
Axel Petzold, Bernard M J Uitdehaag, Sam Hof, Laurentius J van Rijn, Jenny A Nij Bijvank   +4 more
doaj   +1 more source

When to consider an inborn error of immunity: clues for physicians

Internal Medicine Journal, Volume 56, Issue 9, Page 1488-1499, September 2026.
Abstract The term inborn errors of immunity (IEIs) refers to the rapidly expanding group of genetic disorders causing dysregulation of the immune system. With improved genetic testing in recent years, the number of defined IEIs and their range of phenotypic presentations has grown vastly, with more than 550 IEIs now described.
Meera Thangarajah, Lucinda J. Berglund
wiley   +1 more source

Optic Neuritis Treatment Trial - An Editorial

, 1994
IC-H3fi-optic-neuritis-treatment ...
Peter J. Savino, MD
core  

Longitudinal Evaluation of Chromatic Pupillometry and Retinal Thickness in Dogs With Sudden Acquired Retinal Degeneration Syndrome

Veterinary Ophthalmology, Volume 29, Issue 5, September 2026.
ABSTRACT Objective To determine longitudinal changes in chromatic pupillary light reflexes (cPLR) and retinal layers in dogs with sudden acquired retinal degeneration syndrome (SARDS). Animals Studied Clinical evaluation: Fifteen SARDS‐affected and nine control dogs.
Soohyun Kim, Ann E. Cooper, David J. Maggs, Ariana D. Marangakis, Tran Nguyen, Monica Motta, Sara M. Thomasy   +6 more
wiley   +1 more source