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Updated recommendations from the Optic Neuritis Treatment Trial.

The Western journal of medicine, 1995
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Design, methods, and conduct of the optic neuritis treatment trial

Contemporary Clinical Trials, 1993
The Optic Neuritis Treatment Trial (ONTT) was an investigator-initiated, multi-centered, randomized, controlled clinical trial supported by cooperative agreements and grants. It was designed to evaluate the efficacy and safety of oral prednisone or intravenous methylprednisolone followed by oral prednisone as compared with oral placebo.
Patricia A Cleary, P A Cleary
exaly   +3 more sources

Visual function more than 10 years after optic neuritis: experience of the optic neuritis treatment trial

American Journal of Ophthalmology, 2004
To assess visual function more than 10 years after an episode of optic neuritis in patients enrolled in the Optic Neuritis Treatment Trial.Longitudinal follow-up of a randomized clinical trial.Vision testing included measures of visual acuity, contrast sensitivity, and visual field.
Eric Eggenberger, Michael Wall, Jonathan Trobe   +2 more
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Experience of the optic neuritis treatment trial

Current Neurology and Neuroscience Reports, 2004
James J Corbett
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The Optic Neuritis Treatment Trial: Implications for Clinicians

Seminars in Ophthalmology, 1995
(1995). The Optic Neuritis Treatment Trial: Implications for Clinicians. Seminars in Ophthalmology: Vol. 10, No. 3, pp. 214-220.
B, Katz, J D, Trobe, R W, Beck
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Prepublication Blackout in the Optic Neuritis Treatment Trial

Archives of Ophthalmology, 1994
Notwithstanding the cautionary comments of Silberberg, 1 the conclusion that high-dose intravenous methylprednisolone followed by a course of oral prednisolone after a bout of acute optic neuritis will reduce the rate of development of multiple sclerosis (MS) over a 2-year period (in patients with white-matter lesions on magnetic resonance imaging) was
M L, Slavin, R M, Burde
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Optic Neuritis Treatment Trial

Archives of Ophthalmology, 1993
To determine the efficacy of corticosteroids as treatment for acute demyelinative optic neuritis after completion of 1 year of patient follow-up in the Optic Neuritis Treatment Trial.Randomized placebo controlled multicenter clinical trial.Fifteen university or hospital-based centers throughout the United States.Four hundred fifty-seven patients with ...
R W, Beck, P A, Cleary
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Cerebrospinal fluid in acute optic neuritis

Neurology, 1996
The Optic Neuritis Treatment Trial (ONTT) is a prospective study of corticosteroid treatment of acute optic neuritis (ON), with subsequent longitudinal follow-up to determine development of clinically definite multiple sclerosis (CDMS). We analyzed the CSF of 83 patients with clinically isolated ON who underwent lumbar puncture within 24 hours of ...
L A, Rolak, R W, Beck, D W, Paty, W W, Tourtellotte, J N, Whitaker, R A, Rudick   +5 more
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The Optic Neuritis Treatment Trial

Archives of Ophthalmology, 1988
For almost 40 years, neuro-ophthalmologists have debated the efficacy of corticosteroids as a treatment for optic neuritis. Several studies have investigated corticosteroid and corticotrophin treatment in optic neuritis, but all have been inconclusive because of either small sample size or poor design. 1-3 Today we are no more certain of the benefit of
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