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The Optic Neuritis Treatment Trial

Archives of Ophthalmology, 1988
For almost 40 years, neuro-ophthalmologists have debated the efficacy of corticosteroids as a treatment for optic neuritis. Several studies have investigated corticosteroid and corticotrophin treatment in optic neuritis, but all have been inconclusive because of either small sample size or poor design. 1-3 Today we are no more certain of the benefit of
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The SKILL Card Test in Optic Neuritis: Experience of the Optic Neuritis Treatment Trial

Journal of Neuro-Ophthalmology, 2001
Objectives: To assess the value of the Smith-Kettlewell Institute Low Luminance (SKILL) Card test, designed to measure vision at reduced contrast and luminance, among patients with previous optic neuritis. Materials and Methods: The SKILL Card test was administered to 295 patients participating in the Optic Neuritis Treatment Trial (ONTT) follow-up ...
Danielle T. Long   +6 more
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Optic Neuritis Treatment Trial Study

Journal of Neuro-Ophthalmology, 1994
Four percent of the white population in the United States are color blind. Is that figure of clinical value? Not really, just as might be the case for the Optic Neuritis Treatment Trial (ONTT) study. 1 One cannot lump statistics when the incidence of a condition is different for men and women.
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The SKILL Card in the Optic Neuritis Treatment Trial

Vision Science and its Applications, 1997
Optic neuritis is an acute, inflammatory disease of the optic nerve that is usually accompanied by ocular pain, affects more women than men, and may be associated with multiple sclerosis1. A broad range of visual functions are typically affected. The severity of the visual loss varies from a slight visual field deficit to no light perception. Even when
M E Schneck   +3 more
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Recovery of visual field function in the Optic Neuritis Treatment Trial

American Journal of Ophthalmology, 1999
To assess the pattern of recovery of the visual field of patients with optic neuritis and to determine whether all affected portions of the visual field recover similarly or certain portions of the visual field have greater recovery.We reviewed the Humphrey Visual Field (Allergan-Humphrey Inc, San Leandro, California) data from the initial and 6-month ...
J P, Fang, R H, Lin, S P, Donahue
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The impact of the optic neuritis treatment trial on the practices of ophthalmologists and neurologists

Ophthalmology, 1999
To determine whether the Optic Neuritis Treatment Trial (ONTT) results have altered the practice patterns of ophthalmologists and neurologists.Mail survey.A random sample of 987 ophthalmologists and 900 neurologists practicing in the United States were mailed a questionnaire that inquired into decision-making with regard to management of optic neuritis
J D, Trobe   +3 more
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Visual symptoms after optic neuritis. Results from the Optic Neuritis Treatment Trial.

American Journal of Ophthalmology, 1997
As part of the Optic Neuritis Treatment Trial, vision-specific quality-of-life data were collected on the patients at their 6-month visits. The purpose of this study was to determine the types of visual tasks in day-to-day living in which patients have difficulty and to compare the patients' subjective assessment of visual impairment with measurements ...
PA Cleary   +5 more
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Visual Field Profile of Optic Neuritis

Archives of Ophthalmology, 1994
The purpose of this present study was to evaluate longitudinal visual field information for 448 patients over their first year of follow-up in the Optic Neuritis Treatment Trial.We reviewed 6536 automated static visual fields performed on a visual field analyzer (Humphrey Visual Field Analyzer) at nine visits within the 1-year period for each of the ...
J L, Keltner   +3 more
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Optic Neuritis Treatment Trial Study-Reply

Archives of Ophthalmology, 1994
In reply We appreciate the opportunity to respond to Coyle's thoughtful comments. As we noted in our article on the results of the ONTT, the beneficial effect of the regimen of intravenous followed by oral corticosteroids in delaying the development of clinically definite MS was remarkably consistent across strata of the different risk factors for MS,
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The course of visual recovery after optic neuritis. Experience of the Optic Neuritis Treatment Trial.

Ophthalmology, 1995
To define the time course of visual recovery after optic neuritis and factors predictive of this course in the patients enrolled in the Optic Neuritis Treatment Trial.The cohort for this study consisted of the 438 patients who completed the 6-month follow-up visit.
Roy W, Beck   +2 more
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