Results 51 to 60 of about 31,301 (244)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Class structure‐aware adversarial loss for cross‐domain human action recognition

IET Image Processing, 2021
Cross‐domain action recognition is a challenging vision task due to the domain shift and the absence of labeled data in the target domain. With only labelled source domain and unlabelled target domain data during training, some existing methods rely on ...
Wanjun Chen, Long Liu, Guangfeng Lin, Yajun Chen, Jing Wang   +4 more
doaj   +1 more source

Gravity‐Dependent Modulation of Downbeat Nystagmus: Insights From Velocity‐Storage Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Downbeat nystagmus varies with head position, a phenomenon termed gravity‐dependent modulation. We aimed to clarify its mechanism using a velocity‐storage model. Methods In 10 patients with downbeat nystagmus due to cerebellar disorders, we recorded eye movements at different pitch‐ and roll‐axis head positions.
Ji‐Hyung Park, Eun‐Hyuk Choi, Jorge Otero‐Millan, David S. Zee, Jeong‐Yoon Choi, Ji‐Soo Kim   +5 more
wiley   +1 more source

Iterative attribute augmentation network for face image super resolution

Electronics Letters, 2021
Although recently a series of deep‐learning based methods have promoted the performance of face super resolution (FSR), most of these methods cannot recover essential face attributes accurately, especially to super‐resolve a very low‐resolution (LR) face
Zi Teng, Xiaosheng Yu, Chengdong Wu
doaj   +1 more source

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source

Segregation of meaningful strokes, a pre‐requisite for self co‐articulation removal in isolated dynamic gestures

IET Image Processing, 2021
Gesture formation, a pre‐processing step, has its importance when variations in patterns, scale, and speed come into play. Self co‐articulations are intentional movements performed by an individual to complete a gesture, whose presence in the trajectory ...
Anish Monsley K., Kuldeep Singh Yadav, Songhita Misra, Taimoor Khan, M. K. Bhuyan, Rabul Hussain Laskar   +5 more
doaj   +1 more source

Parkinson Disease Subtype Stability and Eventual Convergence

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Previous research identified distinct Parkinson disease (PD) clinical subtypes of “Motor Only,” “Psychiatric & Motor,” and “Cognitive & Motor” based on comprehensive, multidomain classification. Whether these subtypes reflect distinct trajectories or progressive disease stages remains unknown.
Laura M. Rosok, Christina N. Lessov‐Schlaggar, Abdulmunaim M. Eid, Erin R. Foster, Baijayanta Maiti, Hailee Domash, Helen Hwang, Richard J. Perrin, Paul T. Kotzbauer, Joel S. Perlmutter, Meghan C. Campbell   +10 more
wiley   +1 more source

Finger vein recognition algorithm under reduced field of view

IET Image Processing, 2021
Algorithms for finger vein recognition methods are generally designed based on greyscale images containing vein distributions, but greyscale inhomogeneities and non‐venous texture structures often adversely affect the recognition results.
Jian Jin, Si Di, Weijian Li, Xuetong Sun, Xudi Wang   +4 more
doaj   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Dynamic optimization of hessian determinant image pyramid for memory‐efficient and high performance keypoint detection in SURF

IET Image Processing, 2021
With increasing demand for scale‐invariant and fast object recognition, speeded up robust features (SURF) have emerged and become a widely used feature extraction algorithm in computer vision. Nevertheless, SURF still requires high memory usage and heavy
Eunhee Cho, Yoonjin Kim
doaj   +1 more source