Results 61 to 70 of about 78,872 (276)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Photonic Compute-in-Wire: Remotely Driven Photonic Deep Neural Network with a Single Nonlinear Loop

Advanced Devices & Instrumentation
The development of deep learning has motivated the advancement of unconventional computing that leverages analog physical systems such as analog electronics, spintronics, and photonics.
Mitsumasa Nakajima, Satoshi Kawakami, Katsuma Inoue, Kohei Nakajima, Toshikazu Hashimoto   +4 more
doaj   +1 more source

In-materio neuromimetic devices: Dynamics, information processing and pattern recognition

, 2020
The story of information processing is a story of great success. Todays' microprocessors are devices of unprecedented complexity and MOSFET transistors are considered as the most widely produced artifact in the history of mankind.
Gentili, Pier Luigi, Mazur, Tomasz, Przyczyna, Dawid, Szaciłowski, Konrad, Zawal, Piotr   +4 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Opportunities for integrated photonic neural networks

Nanophotonics, 2020
Photonics offers exciting opportunities for neuromorphic computing. This paper specifically reviews the prospects of integrated optical solutions for accelerating inference and training of artificial neural networks.
Stark Pascal, Horst Folkert, Dangel Roger, Weiss Jonas, Offrein Bert Jan   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Quantum digital-to-analog conversion algorithm using decoherence

, 2015
We consider the problem of mapping digital data encoded on a quantum register to analog amplitudes in parallel. It is shown to be unlikely that a fully unitary polynomial-time quantum algorithm exists for this problem; NP becomes a subset of BQP if it ...
SaiToh, Akira
core   +1 more source

Evaluation of Single-Chip, Real-Time Tomographic Data Processing on FPGA - SoC Devices [PDF]

, 2018
A novel approach to tomographic data processing has been developed and evaluated using the Jagiellonian PET (J-PET) scanner as an example. We propose a system in which there is no need for powerful, local to the scanner processing facility, capable to ...
Białas, P., Curceanu, C., Czerwiński, E., Dulski, K., Flak, B., Gajos, A., Gorgol, M., Głowacz, B., Hiesmayr, B. C., Jasińska, B., Kacprzak, K., Kajetanowicz, M., Kisielewska, D., Korcyl, G., Kowalski, P., Kozik, T., Krawczyk, N., Krzemień, W., Kubicz, E., Mohammed, M., Moskal, P., Niedźwiecki, Sz., Pawlik-Niedźwiecka, M., Pałka, M., Raczyński, L., Rajda, P., Rudy, Z., Salabura, P., Sharma, N. G., Sharma, S., Shopa, R. Y., Silarski, M., Skurzok, M., Strzempek, P., Wieczorek, A., Wiślicki, W., Zaleski, R., Zgardzińska, B., Zieliński, M.   +38 more
core   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Plasmonic computing of spatial differentiation

Nature Communications, 2017
For specific problems, analog optical computing can be faster and more computationally efficient than digital methods. Here, Zhuet al. simplify the often metamaterial-based approach to a single thin metal film, with which they demonstrate spatial ...
Tengfeng Zhu, Yihan Zhou, Yijie Lou, Hui Ye, Min Qiu, Zhichao Ruan, Shanhui Fan   +6 more
doaj   +1 more source