Results 81 to 90 of about 78,872 (276)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Analog parallel processor for broadband multifunctional integrated system based on silicon photonic platform

Light: Science & Applications
Sharing the hardware platform between diverse information systems to establish full cooperation among different functionalities has attracted substantial attention.
Na Qian, Defu Zhou, Haowen Shu, Ming Zhang, Xingjun Wang, Daoxin Dai, Xiao Deng, Weiwen Zou   +7 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Cognitive Status in People With Epilepsy in the Republic of Guinea: A Prospective, Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick, Cheick O. Soumah, Malé Doré, Oumar Mara, Desiré Neldje, Fodé A. Cissé, Toure M. Lamine, Aminata Diallo, Seungwon Lee, Siddharth Satish, Alexander J. X. Chen, Alice Liu, Nomin Enkhtsetseg, Farrah J. Mateen, The Guinea Epilepsy Project   +14 more
wiley   +1 more source

Meta‐Device for Field‐of‐View Tunability via Adaptive Optical Spatial Differentiation

Advanced Science
Optical edge detection is a crucial optical analog computing method in fundamental artificial intelligence, machine vision, and image recognition, owing to its advantages of parallel processing, high computing speed, and low energy consumption.
Yin Zhou, Lin Li, Junhao Zhang, Jialuo Cheng, Xiaoyuan Liu, Yunhui Gao, Zihan Geng, Lei Li, Junxiao Zhou, Mu Ku Chen   +9 more
doaj   +1 more source

Monolithic metasurface spatial differentiator enabled by asymmetric photonic spin-orbit interactions

Nanophotonics, 2020
Spatial differentiator is the key element for edge detection, which is indispensable in image processing, computer vision involving image recognition, image restoration, image compression, and so on.
He Qiong, Zhang Fei, Pu MingBo, Ma XiaoLiang, Li Xiong, Jin JinJin, Guo YingHui, Luo XianGang   +7 more
doaj   +1 more source

半導体光増幅器を用いた光デジタル・アナログ相互変換 [PDF]

, 2020
　デジタル・アナログ変換(D/A変換)とアナログ・デジタル変換(A/D変換)は，電子デバイスや光学システム内でデジタル信号とアナログ信号を接続するための重要な機能であり，通信ネットワークを含む幅広い分野で利用されている．近年，デジタル信号処理技術の発達に伴い，より高性能なD/A変換器やA/D変換器の需要が高まっている．しかし，電気的なD/A変換器やA/D変換器は，ジッタ制限，電磁干渉，RC遅延などの高速動作における固有のボトルネックを有している．よって，コストや複雑さを犠牲とし ...
岡田 拓也
core   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Towards Biosensing Strategies Based on Biochemical Logic Systems

, 2009
Recent advances in biochemical computing, i.e., information processing with cascades of primarily enzymatic reactions realizing computing gates, such as AND, OR, etc., as well as progress in networking these gates and coupling of the resulting systems to
Katz, Evgeny, Privman, Vladimir, Wang, Joseph   +2 more
core   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source