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Fiber-optic biosensors – an overview

Analytical and Bioanalytical Chemistry, 2002
This article reviews progress and developments during the past five years in the field of optical fiber biosensors. Because of the expense and time constraints associated with modern laboratory analysis, there is a growing need for real-time, low-cost technology that can be used industrially, environmentally, and clinically, and to monitor food ...
Dolores, Marazuela   +1 more
openaire   +2 more sources

Receptor heterogeneity in optical biosensors

Journal of Mathematical Biology, 2017
Scientists measure rate constants associated with biochemical reactions in an optical biosensor-an instrument in which ligand molecules are convected through a flow cell over a surface to which receptors are immobilized. We quantify transport effects on such reactions by modeling the associated convection-diffusion equation with a reaction boundary ...
Evans, Ryan M., Edwards, David A.
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Optical biosensors for cell adhesion

Journal of Receptors and Signal Transduction, 2009
Planar optical waveguides offer an ideal substratum for cells on which to reside. The materials from which the waveguides are made--high refractive index transparent dielectrics--correspond to the coatings of medical implants (e.g., the oxides of niobium, tantalum, and titanium) or the high molecular weight polymers used for culture flasks (e.g ...
Jeremy J, Ramsden, Robert, Horvath
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A Fiber-Optic Cocaine Biosensor

Analytical Biochemistry, 1995
A fiber-optic biosensor was developed for detection of cocaine, its metabolites, and other coca alkaloids, using a monoclonal antibody (mAb) against a derivatized benzoylecgonine (BE). The mAb was immobilized noncovalently on quartz fibers and a flow fluorometer was used to detect changes in evanescent wave fluorescence. A fluorescein (FL) conjugate of
P J, Devine   +5 more
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Optical fiber-based biosensors

Analytical and Bioanalytical Chemistry, 2004
This review outlines optical fiber-based biosensor research from January 2001 through September 2003 and was written to complement the previous review in this journal by Marazuela and Moreno-Bondi. Optical fiber-based biosensors combine the use of a biological recognition element with an optical fiber or optical fiber bundle. They are classified by the
David J, Monk, David R, Walt
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A Transparent Nanostructured Optical Biosensor

Journal of Biomedical Nanotechnology, 2014
Herein we report a new transparent nanostructured Fabry-Perot interferometer (FPI) device. The unique features of the nanostructured optical device can be summarized as the following: (i) optically transparent nanostructured optical device; (ii) simple and inexpensive for fabrication; (iii) easy to be fabricated and scaled up as an arrayed format ...
Yuan, He, Xiang, Li, Long, Que
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Optical grating coupler biosensors

Biomaterials, 2002
By incorporating a grating in a planar optical waveguide one creates a device with which the spectrum of guided lightmodes can he measured. When the surface of the waveguide is exposed to different solutions, the peaks in the spectrum shift due to molecular interactions with the surface.
Vörös J   +6 more
openaire   +3 more sources

Optical biosensors in drug discovery

Nature Reviews Drug Discovery, 2002
Optical biosensors that exploit surface plasmon resonance, waveguides and resonant mirrors have been used widely over the past decade to analyse biomolecular interactions. These sensors allow the determination of the affinity and kinetics of a wide variety of molecular interactions in real time, without the need for a molecular tag or label.
openaire   +5 more sources

Optical Biosensors for the Detection of Pathogenic Microorganisms

Trends in Biotechnology, 2016
Pathogenic microorganisms are causative agents of various infectious diseases that are becoming increasingly serious worldwide. For the successful treatment of pathogenic infection, the rapid and accurate detection of multiple pathogenic microorganisms is of great importance in all areas related to health and safety.
Yoo, Seung Min, Lee, Sang Yup
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Optical biosensors for detection of exosomes

Clinica Chimica Acta
Exosomes, nanoscale extracellular vesicles secreted by various cell types, have emerged as critical mediators of intercellular communication and valuable indicators of physiological and pathological states. Their stable presence in biofluids and ability to carry disease-specific molecular cargo make them ideal candidates for non-invasive diagnostics ...
Asma, Vafadar   +4 more
openaire   +2 more sources

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