Results 61 to 70 of about 188,860 (267)

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Entanglement-Enhanced Optical Ion Clock

Physical Review Letters
Entangled states hold the promise of improving the precision and accuracy of quantum sensors. We experimentally demonstrate that spectroscopy of an optical clock transition using entangled states can outperform its classical counterpart. Two
Kai Dietze, Lennart Pelzer, Ludwig Krinner, Fabian Dawel, Johannes Kramer, Nicolas C. H. Spethmann, Timm Kielinski, Klemens Hammerer, Kilian Stahl, Joshua Klose, Sören Dörscher, Christian Lisdat, Erik Benkler, Piet O. Schmidt   +13 more
openaire   +3 more sources

Enhancement of Second-Order Nonlinear-Optical Signals by Optical Stimulation

Physical Review Letters, 2015
Second-order nonlinear optical interactions such as sum- and difference-frequency generation are widely used for bioimaging and as selective probes of interfacial environments. However, inefficient nonlinear optical conversion often leads to poor signal-to-noise ratio and long signal acquisition times.
Goodman, Aaron Jacob, Tisdale, William A.   +1 more
openaire   +6 more sources

Improving Depth Sensitive Fluorescence Spectroscopy With Wavefront Shaping by Spectral and Spatial Filtering

IEEE Access, 2019
Depth sensitive optical spectroscopy preferentially detects optical spectra from different depths in layered samples, which plays a crucial role in many applications such as the optical diagnosis of epithelial precancer and cancer.
Chao-Mao Hsieh, Manish Verma, Quan Liu
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Enhanced nonlinearities using plasmonic nanoantennas

Nanophotonics, 2012
In this paper, we review and discuss how nanoantennas may be used to largely enhance the nonlinear response of optical materials. For single nanoantennas, there have been tremendous advancements in understanding how to exploit the local field enhancement
Chen Pai-Yen, Argyropoulos Christos, Alù Andrea   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Optical OCDMA enhanced by nonlinear optics

, 2010
Intended for the next generation of optical access networks, OCDMA is of great interest to meet the demand of increasing the number of users per access fiber, especially as spectral phase coding increases its performance in the optical domain. This, however, requires handling broad spectra and short pulses, which are best dealt with using opto ...
Ware, Cedric, Cordette, Steevy, Lepers, Catherine, Fsaifes, Ihsan, Tonello, Alessandro, Couderc, Vincent, Douay, Marc, Millot, Guy, Finot, Christophe   +8 more
openaire   +2 more sources