Results 41 to 50 of about 3,007,416 (292)

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Dynamic microvascular monitoring with miniaturized omnidirectional broadband photoacoustic imaging system for living entities (MOBILE)

Nature Communications
Microcirculation monitoring is crucial for evaluating cardiovascular health and detecting organ dysfunction early, but existing bedside imaging techniques often cannot provide sufficient resolution and depth for dynamic assessment during natural ...
Wei Li, Xue Bai, Yizhi Liang, Peiqian He, Yachao Zhang, Qi Zhang, Zixuan Zhang, Chaoneng Wu, Changze Song, Shirong Li, Yejing Zheng, Zhixuan Hu, Xiaoxuan Zhong, Linghao Cheng, Long Jin, Bai-Ou Guan   +15 more
doaj   +1 more source

Fiber Taper-Based Mach–Zehnder Interferometer for Ethanol Concentration Measurement

Micromachines, 2019
We present a new type of fiber Mach−Zehnder interferometer based on a fiber taper and a pair of inner air bubbles for highly sensitive ethanol concentration measurement.
Changrui Liao, Feng Zhu, Peng Zhou, Ying Wang   +3 more
doaj   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Special Optical Fibres [PDF]

SPIE Proceedings, 1987
Optical fibres are making ever-increasing inroads into areas traditionally satisfied by older, more established technologies. In particular, sensors which rely on the external modulation of the properties of an optical fibre (intrinsic sensors) are receiving much attention since they can be made extremely sensitive and can be used for distributed ...
Poole, S.B., Payne, D.N.
openaire   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Tunable and switchable dual wavelength lasers using optical fibre Bragg grating external cavities

, 2002
Two novel external cavity lasers are demonstrated experimentally. The first utilises a Bragg grating fabricated in highly birefringent optical fibre and offers the ability to switch between modes that are separated in polarisation and wavelength.
Reilly S. P., Tatam, Ralph P., James, Stephen W., S.W. James, R.P. Tatam, S.P. Reilly   +5 more
core   +1 more source

High sensitivity wide range ethanol concentration measurements in ethanol blended petrol using weakly tilted fiber Bragg grating

Discover Sensors
Due to worldwide increasing interest towards usage of bio-ethanol blended fuel, high accuracy measurement of ethanol content in ethanol blended petrol (EBP) is of high importance for fuel quality assurance. In the present work, we report high sensitivity
P. K. Saini, J. Kumar, O. Prakash
doaj   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source