Results 51 to 60 of about 3,010,687 (303)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Au Nanospirals Transferred onto PDMS Film Exhibiting Circular Dichroism at Visible Wavelengths
Micromachines, 2020 We propose a thin, single-layered circular dichroic filter with Au nanospiral structures on a polydimethylsiloxane (PDMS) thin film that has strong circular dichroism at visible wavelengths.
Gaku Furusawa, Tetsuo Kan
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
PhotonicsLight confinement provided by whispering gallery mode (WGM) microresonators is especially useful for integrated photonic circuits. In particular, the tunability of such devices has gained increased attention for active filtering and lasering applications.
Gabriel H. A. Jorge +5 more
doaj +1 more source
Applied Sciences, 2020 Here, by harnessing a composite combination of wave retarders, we propose and experimentally demonstrate a first-order narrowband fiber comb filter capable of continuously tuning its wavelength, of which the filter structure is on the fundamental basis ...
Jaehoon Jung, Yong Wook Lee
doaj +1 more source
Using a GPS-Aided Inertial System for Coarse-Pointing of Free-Space Optical Communication Terminals [PDF]
, 2006 In the Capanina project, it has been shown that it is possible to use solely GPS positions for coarse-pointing of a stratospheric free-space optical communication terminal.
Bernhard Epple, Epple, Bernhard
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
AxiomsWith the vigorous development of emerging technology and the advent of the Internet generation, high-speed Internet and fast transmission 5G wireless networks contribute to interpersonal communication.
You-Shyang Chen +5 more
doaj +1 more source
Applied Sciences, 2020 We present a tunable terahertz (THz) metamaterial using an electric split-ring resonator (eSRR), which exhibits polarization-sensitive characteristics. The proposed eSRR is composed of double symmetrical semicircles and two central metal bars.
Tao Xu, Yu-Sheng Lin
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source