Results 131 to 140 of about 34,279 (294)

Mirikizumab pharmacokinetics and exposure–response in pediatric patients with moderate‐to‐severe ulcerative colitis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 474-485, March 2025.
Abstract Mirikizumab is a p19‐directed anti‐interleukin‐23 antibody approved for the treatment of adults with moderate‐to‐severe ulcerative colitis (UC). Here, we report the first data of mirikizumab pharmacokinetics (PK) and exposure–response (E/R) relationships in pediatric participants (aged 2 to <18 years weighing >10 kg) with moderate‐to‐severe UC
Yuki Otani, Laiyi Chua, Wendy J. Komocsar, Amy Larkin, Jordan Johns, Xin Zhang   +5 more
wiley   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

AT2022sxl: A Candidate Repeating Tidal Disruption Event in Possible Association with Two High-energy Neutrino Events

The Astrophysical Journal
We report a candidate repeating tidal disruption event (TDE), AT2022sxl, found from large-field optical survey data. Two flares with a separation time of ∼7.2 yr between the two optical peaks are observed.
Shunhao Ji, Zhongxiang Wang, Litao Zhu, Stefan Geier, Alok C. Gupta   +4 more
doaj   +1 more source

Scalable Room‐Temperature Terahertz Graphene Cameras

Small Methods, EarlyView.
ABSTRACT Terahertz (THz) imaging has emerged as a powerful tool for non‐destructive, label‐free analysis across several scientific disciplines, ranging from materials science to biomedical research. By capturing the spatial‐dependent information in a broad range of frequencies, this technique enables the identification of chemical composition ...
Lili Shi, Leonardo Viti, Miriam S. Vitiello   +2 more
wiley   +1 more source

Tracing the Light: Identification for the Optical Counterpart Candidates of Binary Black Holes during O3

The Astrophysical Journal
The accretion disks of active galactic nuclei (AGN) are widely considered the ideal environments for binary black hole mergers and the only plausible sites for their electromagnetic counterparts. M. J. Graham et al.
Lei He, Zhengyan Liu, Rui Niu, Bingzhou Gao, Mingshen Zhou, Purun Zou, Runduo Liang, Wen Zhao, Ning Jiang, Zhen-Yi Cai, Zi-Gao Dai, Ye-Fei Yuan   +11 more
doaj   +1 more source

Sequential Reduction of Chromite Pellets Using Hydrogen and Silicon Carbide for Carbon Emission Abatement During Ferrochrome Production

steel research international, EarlyView.
H2 prereduction selectively metallizes Fe in UG2 chromite pellets at 1100°C, while silicon carbide becomes active at 1300°C to convert remaining Cr2O3 to carbides and promote Cr metallization. By separating the roles of H2 and SiC, the sequential route reaches up to 65.7% Cr metallization and suppresses in‐furnace CO generation by ≈75% versus ...
D. Coertzen, M. Tangstad, J. P. Beukes, P. G. van Zyl, D. G. Bessarabov, S. P. du Preez   +5 more
wiley   +1 more source

Systematic Learning and Pedagogy Through a Modular, Progressive‐Based Simulation Modeling Framework for Complex Systems

Systems Engineering, EarlyView.
ABSTRACT Smart Transportation Systems (SmTS) will exceed complex systems with their classification as complex, sociotechnical, and AI‐based systems. Possessing a toolkit that helps systemically understand, analyze, and assess these systems will be advantageous in the early stages of the systems engineering (SE) lifecycle, and Agent Based Models (ABMs ...
Ifezue V. Obiako, Sean B. Walker, Kari J. Lippert, Robert J. Cloutier   +3 more
wiley   +1 more source

Repeating flares, X-ray outbursts and delayed infrared emission: A comprehensive compilation of optical tidal disruption events

Astronomy & Astrophysics
Tidal disruption events (TDEs) have been proposed as valuable laboratories for studying dormant black holes. However, progress in this field has been hampered by the limited number of observed events.
Langis D. A., Liodakis I., Koljonen K. I. I., Paggi A., Globus N., Wyrzykowski L., Mikołajczyk P. J., Kotysz K., Zieliński P., Ihanec N., Ding J., Morshed D., Torres Z.   +12 more
doaj   +1 more source

Threshold Currents of Vacuum Arcs With Tungsten and Copper Cathodes

High Voltage, EarlyView.
ABSTRACT This paper presents the results of an experimental study aimed at determining the threshold current for triggering a vacuum arc discharge, the probability of arc ignition and the average arc operation time depending on the current for tungsten and copper electrodes.
P. S. Mikhailov, I. L. Muzyukin, I. V. Uimanov, D. L. Shmelev, S. A. Barengolts   +4 more
wiley   +1 more source

Classifying Optical (Out)bursts in Cataclysmic Variables: The Distinct Observational Characteristics of Dwarf Novae, Micronovae, Stellar Flares, and Magnetic Gating

The Astrophysical Journal Letters
Cataclysmic variables can experience short optical brightenings, which are commonly attributed to phenomena such as dwarf novae outbursts, micronovae, donor flares, or magnetic gating bursts.
Krystian Iłkiewicz, Simone Scaringi, Martina Veresvarska, Domitilla De Martino, Colin Littlefield, Christian Knigge, John A. Paice, Anwesha Sahu   +7 more
doaj   +1 more source