Results 91 to 100 of about 466,055 (265)

Stabilization of fluoroindate glasses by magnesium fluoride and other heavy metal fluorides

open access: yesQuímica Nova, 1998
Their extended transparency in the IR makes them attractive for use as optical fibers for CO laser power delivery and optical amplification. This paper firstly describes the spectacular stabilizing effect of MgF2 on the binary system InF3-BaF2.
B. J. Costa, A. Soufiane, Y. Messaddeq
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

EFFICIENCY OF TWO-CHANNEL OPTICAL RECEIVER FOR DIFFERENTIAL PHASE-SHIFT KEYING SIGNALS

open access: yesДоклады Белорусского государственного университета информатики и радиоэлектроники, 2019
A comparative analysis of optical receivers to handle differential phase-shift keying (DPSK) was presented in this paper. The two-channel optical receiver providing sensitivity gain was proposed. Numerical investigation of its performance was carried out.
V. N. Uryadov   +3 more
doaj  

AZO Nanoparticles-Decorated CNTs for UV Light Sensing: A Structural, Chemical, and Electro-Optical Investigation. [PDF]

open access: yesNanomaterials (Basel), 2023
Filice S   +6 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Fast Optical Investigation of Cardiac Electrophysiology by Parallel Detection in Multiwell Plates. [PDF]

open access: yesFront Physiol, 2021
Credi C   +10 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

High temperature photoluminescence sensitivity of Te4+ in silver nanoparticle tellurite glasses: Application as optical temperature sensor

open access: yesNext Materials
Tellurite glasses with the composition (in mol%) (100-x)(75TeO2:25Li2O):xAgNO3 (x = 0, 0.6, and 1.2) were synthesized at 800 °C in an ambient atmosphere, for investigation of the influence of Ag nanoparticles on the Te4+ semi metal ion photoluminescence (
Adriana do Carmo Capiotto   +4 more
doaj   +1 more source

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