Results 71 to 80 of about 466,055 (265)

ELECTROPHYSIOLOGICAL INVESTIGATIONS ON THE PIGEON'S OPTIC TECTUM [PDF]

Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, 1971
Electrical responses of the cells at different depths of the pigeon's optic tectum to different visual stimuli were recorded.Point to point representation of the upper visual field on the dorsal surface of the tectum was obtained as a projection on a horizontal stereotaxic plane.Different units in the stratum griseum et fibrosum superficiale of the ...
openaire   +2 more sources

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Optical investigation of nanophotonic lithium niobate-based optical waveguide

Applied Physics B, 2015
Lithium niobate (LiNbO3) nanophotonics are prepared on quartz substrate by sol–gel method. They have been deposited with different molarity concentrations and annealed at 500 °C. These samples are characterized and analyzed by scanning electron microscope, atomic force microscopy, X-ray diffraction and ultraviolet–visible.
Fakhri, Makram A., Al-Douri, Y., Hashim, U., Salim, Evan T., Prakash, Deo, Verma, K. D.   +5 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

OPTICAL EFFECTS AT NONMETALLIC MATERIALS MICROSCOPY

Литьë и металлургия, 2017
The optical effects which appeared on internal defects of optically transparent materials by use of various methods of optical staining, i. e. dark-field illumination and polarized light were researched.
A. G. Anisovich
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Investigation of 2H/1T/1T′ phase MoS2 optical nonlinearity

Discover Nano
2H and 1T/1T′ molybdenum disulfide (MoS2) are typical phases that can be found in crystalline and thin film materials. In this work, by controlling the atmosphere during thin film chemical vapor deposition, 2H or 1T/1T′ phase MoS2 are grown separately ...
Hsuan-Sen Wang, Shih-Po Su, Yi-Hsuan Huang, Li-Wei Tu, Paritosh V. Wadekar, Hsiang-Chen Wang, Chao-Kuei Lee   +6 more
doaj   +1 more source