Results 51 to 60 of about 4,324 (259)
APL Photonics, 2020 This work investigates the performance of 1.3-μm quantum dot lasers epitaxially grown on silicon under optical feedback sensitivity with different temperature and doping profiles.
H. Huang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Nanophotonics, 2021 To realize nonreciprocal transmission, it is necessary to break the time-reversal symmetry of the transmission system, but it is very challenging to keep the linear polarized (LP) input and output unchanged in the free space transmission system ...
Tan Zhiyu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Saturated Gain-Induced Non-Reciprocal Transmission and Broadband On-Chip Optical Isolator
PhotonicsTo overcome the limitation of dynamic reciprocity, a new method for designing broadband on-chip optical isolators is proposed and demonstrated based on saturated gain, which is able to support simplex and duplex operation modes. By connecting a saturated
Mingyuan Xue +3 more
doaj +1 more source
APL Materials, 2019 In this report, dysprosium substituted Ce1Y2Fe5O12 (Ce:YIG) thin films (Dy:CeYIG) with perpendicular magnetic anisotropy (PMA) are successfully deposited on silicon and silicon-on-insulator waveguides by pulsed laser deposition. The structural, magnetic,
Yan Zhang +7 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
IEEE Photonics Journal, 2020 We investigate optical property of polarization-maintaining fiber taper (PMFT) for tunable multi-wavelength laser generation in a fiber ring cavity. A panda-type polarization fiber is fused and tapered into a fiber taper with a diameter of about 2.5 ...
Feng Yuan +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source