Results 121 to 130 of about 4,290,469 (326)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Optogenetics enables real-time spatiotemporal control over spiral wave dynamics in an excitable cardiac system

eLife, 2018
Propagation of non-linear waves is key to the functioning of diverse biological systems. Such waves can organize into spirals, rotating around a core, whose properties determine the overall wave dynamics. Theoretically, manipulation of a spiral wave core
Rupamanjari Majumder, Iolanda Feola, Alexander S Teplenin, Antoine AF de Vries, Alexander V Panfilov, Daniel A Pijnappels   +5 more
doaj   +1 more source

High-Throughput Analysis of Optical Mapping Data Using ElectroMap.

Journal of Visualized Experiments, 2019
Optical mapping is an established technique for high spatio-temporal resolution study of cardiac electrophysiology in multi-cellular preparations. Here we present, in a step-by-step guide, the use of ElectroMap for analysis, quantification, and mapping ...
Christopher O'Shea, Andrew P. Holmes, T. Yu, James Winter, S. Wells, Beth A Parker, D. Fobian, Daniel M. Johnson, Joao N. Correia, Paulus Kirchhof, L. Fabritz, K. Rajpoot, D. Pavlovic   +12 more
semanticscholar   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

The Design and Use of an Optical Mapping System for the Study of Intracardiac Electrical Signaling

Indian Pacing and Electrophysiology Journal, 2012
Fluorescent optical mapping of electrically active cardiac tissues provides a unique method to examine the excitation wave dynamics of underlying action potentials.
Maneesh Shrivastav, PhD, Megan B. Ghai, Ashish Singal, Paul A. Iaizzo, PhD   +3 more
doaj   +1 more source

UV albedo of clouds from TOMS data [PDF]

The Pilot Climate Data System (PCDS) was found to be useful in examining a subset of data from the Nimbus-7 Total Ozone Mapping Spectrometer (TOMS). The TOMS instrument scans with six channels between .3 and .4 micrometers.
Short, D.
core   +1 more source

RHYTHM: An Open Source Imaging Toolkit for Cardiac Panoramic Optical Mapping

Scientific Reports, 2018
Fluorescence optical imaging techniques have revolutionized the field of cardiac electrophysiology and advanced our understanding of complex electrical activities such as arrhythmias. However, traditional monocular optical mapping systems, despite having
C. Gloschat, Kedar K. Aras, Shubham Gupta, N. R. Faye, Hanyu Zhang, R. Syunyaev, Roman Pryamonosov, Roman Pryamonosov, J. Rogers, M. Kay, I. R. Efimov, I. R. Efimov   +11 more
semanticscholar   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Large-Scale Structural Variation Detection in Subterranean Clover Subtypes Using Optical Mapping

Frontiers in Plant Science, 2018
We selected two genetically diverse subspecies of the Trifolium model species, subterranean clover cvs. Daliak and Yarloop. The structural variations (SVs) discovered by Bionano optical mapping (BOM) were validated using Illumina short reads.
Yuxuan Yuan, Yuxuan Yuan, Zbyněk Milec, Philipp E. Bayer, Philipp E. Bayer, Jan Vrána, Jaroslav Doležel, David Edwards, David Edwards, William Erskine, William Erskine, Parwinder Kaur, Parwinder Kaur, Parwinder Kaur   +13 more
doaj   +1 more source

Comparison of Random Forest and XGBoost Classifiers Using Integrated Optical and SAR Features for Mapping Urban Impervious Surface

Remote Sensing
The integration of optical and SAR datasets through ensemble machine learning models shows promising results in urban remote sensing applications. The integration of multi-sensor datasets enhances the accuracy of information extraction.
Zhenfeng Shao, Muhammad Nasar Ahmad, Akib Javed   +2 more
semanticscholar   +1 more source